3D printing glass micro-objectives for ultrathin endoscope

3D打印超薄内窥镜玻璃显微物镜

基本信息

  • 批准号:
    10544780
  • 负责人:
  • 金额:
    $ 16.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

Abstract We propose to develop 3D printing technology of glass micro-objective and micro optics for ultrathin endoscope to address the increasing demand in developing compact endoscopes in cancer imaging. The primary challenge in developing micro-objective is the fabrication, traditional fabrication methods don’t have sufficient capabilities in fabricating micro optics. GRIN lens is the only commercially available micro-objective, but it has a number of limitations, such as narrow working spectrum and very short working distance. 3D printing process has been developed recently to print polymer micro-objective with two-photon polymerization (TPP) process. However, there are some inherent limitations in printed polymer optics, including short lifetime due to the yellowish, low transmission in UV and NIR spectrum, and limitations in hardness, thermal resistance, and chemical resistance. Glass optics is preferred for clinical application because of its excellent optical, chemical, and thermal properties. To meet the increasing needs of high-precision glass micro-optics for endoscope and address the major limitations of current 3D printing optics, we have developed a solvent-free, pre-condensed liquid silica resin (LSR) and two-photon 3D printing process for glass optics. 3D printing of glass micro-optics with isotropic shrinkage, micrometer resolution, low deviation peak-to-valley value (<100 nm), and low surface roughness (< 6 nm) has been achieved. The solvent-free, UV curable LSR with a majority of the already formed covalent bonds (Si-O-Si) is novel that it significantly reduces the material shrinkage, increases the printing speed, and simplifies the process to obtain inorganic silica. The printed glass micro optics has better imaging performance with higher resolution, wider working spectrum, better transmission from UV to NIR, and longer lifetime. The 3D printing process for micro glass objective is novel in that it can fabricate more complex optical systems and is particularly suitable for rapid prototyping at low-cost. The goal of this project is to develop 3D printed glass micro-objective and micro optics for ultra-compact endoscope. We will first optimize pre-condensed LSR (Aim 1), and then print micro-objectives and evaluate the performance (Aim 2). This project is significant in that it will establish a new 3D printing technology for fabricating the much-needed glass micro-objective and micro-optics for endoscope in cancer imaging. The rapid prototyping capability at low cost will accelerate the rapid transition of the advanced imaging technologies from the lab to clinical applications.
摘要

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Rongguang Liang其他文献

Rongguang Liang的其他文献

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{{ truncateString('Rongguang Liang', 18)}}的其他基金

Single viewpoint panoramic imaging technology for colonoscopy
肠镜单视点全景成像技术
  • 批准号:
    10580165
  • 财政年份:
    2023
  • 资助金额:
    $ 16.38万
  • 项目类别:
3D printing glass micro-objectives for ultrathin endoscope
3D打印超薄内窥镜玻璃显微物镜
  • 批准号:
    10377856
  • 财政年份:
    2022
  • 资助金额:
    $ 16.38万
  • 项目类别:
Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting
用于资源匮乏环境下口腔癌检测和诊断的多模态口腔内成像系统
  • 批准号:
    10663873
  • 财政年份:
    2021
  • 资助金额:
    $ 16.38万
  • 项目类别:
Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource Setting
用于资源匮乏环境下口腔癌检测和诊断的多模态口腔内成像系统
  • 批准号:
    10465103
  • 财政年份:
    2021
  • 资助金额:
    $ 16.38万
  • 项目类别:
Improving AI/ML-Readiness of data generated from NIH-funded research on oral cancer screening
提高 NIH 资助的口腔癌筛查研究生成的数据的 AI/ML 就绪性
  • 批准号:
    10594120
  • 财政年份:
    2021
  • 资助金额:
    $ 16.38万
  • 项目类别:
Structured chromatic light sheet microscopy
结构色光片显微镜
  • 批准号:
    10171843
  • 财政年份:
    2020
  • 资助金额:
    $ 16.38万
  • 项目类别:
Low-cost Mobile Oral Cancer Screening for Low Resource Setting
资源匮乏的低成本移动口腔癌筛查
  • 批准号:
    9762395
  • 财政年份:
    2018
  • 资助金额:
    $ 16.38万
  • 项目类别:
Low-cost Mobile Oral Cancer Screening for Low Resource Setting
资源匮乏的低成本移动口腔癌筛查
  • 批准号:
    9788365
  • 财政年份:
    2018
  • 资助金额:
    $ 16.38万
  • 项目类别:
Low-cost Mobile Oral Cancer Screening for Low Resource Setting
资源匮乏的低成本移动口腔癌筛查
  • 批准号:
    9031360
  • 财政年份:
    2016
  • 资助金额:
    $ 16.38万
  • 项目类别:
Fourier Ptychographic Endoscopy
傅里叶叠层内窥镜检查
  • 批准号:
    9247780
  • 财政年份:
    2016
  • 资助金额:
    $ 16.38万
  • 项目类别:

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