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Rush Alzheimer's Disease Core Center

拉什阿尔茨海默病核心中心

基本信息

批准号：
9320959
负责人：
DAVID ALAN BENNETT
金额：
$ 270.24万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-15 至 2021-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9320959
关键词：
Aging Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s Disease Core Center Area Autopsy Biochemical Biological Markers Brain Cessation of life Clergy Clinical Cohort Studies Communities Cultural Diversity Data Data Collection Data Set Dementia Diagnosis Education Elderly Enrollment Environment Ethnic Origin Etiology Evaluation Exercise Funding Genomics Goals Impaired cognition Institution Latino Leadership Link Measures Medical Mentorship Methodology Molecular Parkinsonian Disorders Participant Pathogenesis Pathologic Pathology Performance Peripheral Persons Pilot Projects Prevention Procedures Process Proteomics Race Recruitment Activity Religion and Spirituality Research Research Infrastructure Research Personnel Research Priority Resource Sharing Resources Risk Factors Source Specimen Structure Systems Biology Techniques Time Translational Research Trust Universities Work brain tissue collaborative environment community based participatory research data management design disorder prevention drug discovery education research epigenomics ethnic minority population follow-up health disparity indexing innovation member metabolomics mild cognitive impairment motor impairment multidisciplinary neuroimaging neuropathology new therapeutic target normal aging operation outreach programs psychologic public health priorities racial minority relational database transcriptomics

项目摘要

ABSTRACT - OVERVIEW The overall goal of the proposed renewal of the Rush Alzheimer’s Disease Core Center (Rush ADCC) is to continue to support the performance of cutting edge and innovative research on the etiology, pathogenesis, diagnosis, treatment, and prevention of MCI, AD, and other common dementias, by providing researchers with a stimulating multi-disciplinary environment, and unique and highly valued clinical and post-mortem data, and ante- and post-mortem biologic specimens. The Rush ADCC has been in continuous operation since 1991. It has eight Cores carefully designed to support a variety of timely and important areas of research including studies: 1) of the transition from normal aging to MCI and to the earliest stages of dementia with substantial participation by racial and ethnic minorities, 2) linking risk factors to normal aging, incident MCI and incident AD, and to post-mortem indices of AD and mixed pathologies, 3) that incorporate contemporary high throughput biochemical and molecular data into clinical-pathologic cohort studies, and 4) that link neuroimaging and biofluid biomarkers to contemporary biochemical and molecular data, 5) that support drug discovery pipelines, and 6) that support studies of impaired motor function. The Administrative Core will provide scientific leadership to the ADCC as a whole. The Clinical Core will collect UDS and additional data on Blacks without dementia and work to obtain brain autopsy. The Religious Orders Study (ROS) Core will follow older members of Catholic religious communities who have agreed to annual evaluation and brain donation at death. The Latino Core will collect the same data as in ROS on older Latinos without dementia and work to obtain brain autopsy. The Neuropathology Core will process, store, evaluate and distribute biospecimens obtained by the Clinical, ROS, and Latino Cores. The Outreach and Recruitment Core will provide a wide range of educational programs to support outreach and recruitment of racial and ethnic minorities into the Clinical and Latino Cores, and other NIA funded initiatives. The Data Management and Statistical Core will continue to provide the infrastructure that allows all other Cores to be maximally successful and impactful, and will provide statistical support to users of ADCC resources especially junior investigators and trainees. The new Research and Education Component will provide a structured program of mentorship across the ADCC, Rush University of the Rush ADCC strategic partners.

摘要-概述