Tissue Procurement Shared Facility

组织采购共享设施

• 批准号: 9254462
• 负责人: WILLIAM E. GRIZZLE
• 金额: $ 18.36万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9254462
• 关键词: Accreditation; Advisory Committees; Advocacy; Advocate; African American; American; Area; Autopsy; Basic Science; Benign; Biological; Cancer Center; Catchment Area; Clinical Data; Clinical Pathology; Clinical Protocols; Clinical Research; Clinical Trials; Collaborations; Collection; Communication; Complex; Comprehensive Cancer Center; Computerized Medical Record; Consultations; Custom; Cytopathology; Data; Development; Disease; Education; Education and Outreach; Educational workshop; Ensure; Environment; Equipment; Experimental Designs; Financial Support; Freezing; Funding; Gap Junctions; Goals; Grant; Histology; Human; Human Resources; Individual; Informatics; Information Technology; Institution; International; Leadership; Liquid substance; Methodology; Minority; Mission; Monitor; Online Systems; Operative Surgical Procedures; Paraffin; Pathologic; Pathologist; Pathology; Patients; Physician Assistants; Play; Practice Guidelines; Preparation; Procedures; Process; Productivity; Protocols documentation; Publications; Race; Recruitment Activity; Reporting; Research; Research Personnel; Research Support; Resources; Role; Science; Secure; Services; Slide; Societies; Solid; Source; Specialist; Specimen; Standardization; Strategic Planning; Surgical Pathology; System; Time; Tissue Banks; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Biology; United States National Institutes of Health; University of Alabama at Birmingham Cancer Center; Update; Work; anticancer research; base; biobank; cancer therapy; college; cost; cost effective; cost effectiveness; diagnostic accuracy; human tissue; improved; member; neoplastic; new technology; novel; operation; outreach program; programs; repository; sample collection; tissue processing; translational study

CLINICAL RESEARCH GROUP TISSUE PROCUREMENT SHARED FACILITY (TPSF) ABSTRACT The goal of the UAB Comprehensive Cancer Center Tissue Procurement Shared Facility (TPSF) is to promote the research undertaken by UAB-CCC investigators by ensuring the availability of relevant, high quality human tissues. The TPSF accomplishes this through the collection, processing, storage, and distribution of a wide range of human tissues. Neoplastic and control tissues are supplied as fresh, frozen, paraffin-processed specimens or tissue sections. Bodily fluids and fluid components also can be provided. Pathologists evaluate all solid tissues supplied for research for quality and diagnostic accuracy. The supplementary services provided, including specialized histology, macrodissection and customized clinical data, are of demonstrable significance to the UAB-CCC investigators as are the ability of the TPSF to work effectively with other UAB- CCC Shared Facilities and affiliates. The TPSF leadership provides expert individual guidance to the UAB- CCC investigators in experimental design and the effective use of emerging methodologies in basic and translational research, as well as ensuring compliance in the changing regulatory environment. The leadership's expertise is based on active research in the area of tissue processing and banking as well as their participation in educational and outreach programs at the local, national and international levels. Strategic planning has been used to harness institutional and philanthropic resources to expand the capabilities of the Facility while improving the cost-effectiveness of its operations. Initiatives that have been undertaken since 2011 include extensive renovations, updating of equipment and harmonization of standard-operating- procedures for accreditation by the College of American Pathologists; continued improvements in information technology applications that will enhance research capabilities while reducing labor costs; and establishment of the CCC Tissue Bank. Institutional support has permitted targeted recruitment of an additional pathologist, an informatics specialist, and a pathology physician's assistant to aid the TPSF. The TPSF serves investigators in all six UAB-CCC programs and since 2011 its involvement in clinical trials has tripled. It plays a central role in promoting the mission of the Cancer Center in terms of providing tissues from African-American patients that support their inclusion in early translational studies. From March 2011 to March 2015 the TPSF has supported requests from 57 UAB-CCC investigators and has supported 32 clinical trials. Between January and December 2014 the facility provided 38 UAB-CCC investigators with 919 fresh or frozen human tissue samples, 754 paraffin blocks, and 12,925 slides. TPSF-supported research has been reported in over 120 publications during this time period. Since 1978, the facility has provided approximately 212,000 tissue specimens, blocks, and slides to investigators at UAB. These have been used in a total of 1,295 publications.

临床研究小组 组织采购共享因子（TPSF） 摘要 UAB综合癌症中心组织采购共享设施（TPSF）的目标是促进 UAB-CCC研究人员通过确保相关的高质量人力资源的可用性进行的研究 组织中TPSF通过收集、处理、存储和分发广泛的 一系列人体组织肿瘤和对照组织以新鲜、冷冻、石蜡处理的形式提供 标本或组织切片。还可以提供体液和流体组分。病理学家评估 为研究提供的所有实体组织的质量和诊断准确性。的补充业务 所提供的，包括专门的组织学，宏观解剖和定制的临床数据， 对UAB-CCC调查人员的重要性，以及TPSF与其他UAB有效合作的能力- CCC共享设施和附属机构。TPSF领导层为UAB提供专家个人指导- CCC研究人员在实验设计和有效利用新兴的方法，在基本和 转化研究，以及确保在不断变化的监管环境中的合规性。的 领导的专业知识是基于积极的研究领域的组织处理和银行，以及他们的 参与地方、国家和国际各级的教育和外联方案。战略 规划已被用来利用机构和慈善资源，以扩大能力， 同时提高其业务的成本效益。自2001年以来采取的举措 2011年包括大规模翻修、更新设备和统一标准操作系统， 美国病理学家学会的认证程序;信息的不断改进 在降低劳动力成本的同时提高研究能力的技术应用; CCC组织库机构支助使得有针对性地增聘了一名病理学家， 信息学专家和一名病理学医生助理协助TPSF。TPSF为研究人员提供以下服务： 所有六个UAB-CCC项目，自2011年以来，其参与临床试验的人数增加了两倍。它在以下方面发挥着核心作用： 促进癌症中心的使命，提供来自非洲裔美国人患者的组织， 支持它们被纳入早期的翻译研究。从2011年3月到2015年3月，TPSF支持了 57名UAB-CCC研究者的要求，并支持了32项临床试验。一月至 2014年12月，该机构向38名UAB-CCC调查人员提供了919份新鲜或冷冻人体组织 样本，754个石蜡块和12，925个载玻片。据报道，TPSF支持的研究已在120多个国家开展。 在此期间出版。自1978年以来，该设施已提供约212，000个组织， 标本、组织块和载玻片交给UAB的研究人员。这些已在总共1，295种出版物中使用。