Cell & Tissue Models
细胞
基本信息
- 批准号:9284465
- 负责人:
- 金额:$ 18.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAirAutopsyB-LymphocytesBasic ScienceBiological AssayBiological ModelsBioreactorsCell CountCell Culture TechniquesCell LineCell SeparationCell modelCell physiologyCellsCollectionCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDevelopmentDimensionsDiseaseDrug ModelingsEffectivenessEngineeringEnsureEnvironmentEpithelialEpithelial CellsEpitheliumEvaluationExcisionExhibitsFoundationsFresh TissueFunctional disorderGenerationsGenotypeGlandGoalsHumanIntestinal MucosaIntestinesInvestigationIon TransportLeadLiquid substanceLungLung TransplantationMethodsModelingMucinsMutationNasal PolypsNoseOperative Surgical ProceduresOrganOrganoidsPatientsPharmaceutical PreparationsPolypectomyProductionPropertyQuality ControlResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesRespiratory SystemRespiratory tract structureSecond Pregnancy TrimesterSerial PassageSourceStem cellsStructure of parenchyma of lungSurfaceTermination of pregnancyTestingTherapeuticTissue ModelTissue SampleTissuesTracheobronchialTranslational ResearchTranslationsTransplantationabortionairway surface liquidbaseclinical materialcystic fibrosis airwaydrug candidatedrug discoveryhigh throughput screeninghuman tissueimmortalized cellimprovedin vitro Modelinstrumentationinterestmodel developmentneoplastic cellnovelnovel therapeutic interventionpersonalized medicinepre-clinicalranpirnaserespiratoryscreeningsmall moleculesmall molecule therapeuticstherapeutic evaluation
项目摘要
ABSTRACT
The primary objective of the Cell & Tissue Models Core (Core B) is supporting the CF drug discovery efforts of
participating investigators by providing state-of-the-art, CF-relevant cell and tissue models. More than 20
projects described in this renewal will utilize Core B for cell and/or tissue models. These models are used in
high throughput screening assays, testing of lead compounds, therapeutically relevant preclinical bioassays,
and translational science investigations of CF and airway pathophysiology. The Cell & Tissues Core achieves
its objective via an infrastructure for the collection of CF-relevant tissues; instrumentation and expertise for cell
isolation, culture, storage and quality control; adaptation and development of novel cell culture methods; and
convenient distribution of cell models and tissues to CF investigators. Highly differentiated planar cell models
of respiratory tract surface epithelial cells and submucosal gland cells that replicate native ion transport, airway
surface liquid formation and mucin secretion remain the major cell model provided by the Core. In addition to
our long-established strength in providing these models, the core has developed expertise in three-dimensional
organotypic models (organoids), rotary wall vessel bioreactor cultures and conditionally reprogrammed cells.
Organoids and rotary wall vessel bioreactor cultures provide a tissue-like environment that encourages cellular
differentiation. Both methods increase the number of culture units available per tissue sample potentially
generating more efficient, disease-relevant models for drug discovery. Conditionally reprogrammed cells allow
expansion of CF cells through serial passaging allowing increased production of CF cell models and
development of more efficient assays for evaluating small molecules. Using conditional reprogramming for
producing more cell models from limited numbers of cells exhibiting rare CF genotypes will aid the
development of “personalized” therapies.
摘要
项目成果
期刊论文数量(0)
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WALTER E FINKBEINER其他文献
WALTER E FINKBEINER的其他文献
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{{ truncateString('WALTER E FINKBEINER', 18)}}的其他基金
STUDIES OF AIRWAY SUBMUCOSAL GLANDS AND EPITHELIAL CELLS
气道粘膜下腺和上皮细胞的研究
- 批准号:
3081826 - 财政年份:1984
- 资助金额:
$ 18.11万 - 项目类别:
STUDIES OF AIRWAY SUBMUCOSAL GLANDS AND EPITHELIAL CELLS
气道粘膜下腺和上皮细胞的研究
- 批准号:
3081827 - 财政年份:1984
- 资助金额:
$ 18.11万 - 项目类别:
STUDIES OF AIRWAY SUBMUCOSAL GLANDS AND EPITHELIAL CELLS
气道粘膜下腺和上皮细胞的研究
- 批准号:
3081824 - 财政年份:1984
- 资助金额:
$ 18.11万 - 项目类别:
STUDIES OF AIRWAY SUBMUCOSAL GLANDS AND EPITHELIAL CELLS
气道粘膜下腺和上皮细胞的研究
- 批准号:
3081825 - 财政年份:1984
- 资助金额:
$ 18.11万 - 项目类别:
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