Administrative Core

行政核心

• 批准号: 10660987
• 负责人: Robert O Wright
• 金额: $ 50.13万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10660987
• 关键词: Acceleration; Address; Age; Analytical Chemistry; Automation; Bioinformatics; Biological Assay; Biological Markers; Biology; Blinded; Budgets; Chemical Exposure; Chemicals; Child Health; Client; Clinical Chemistry; Clinical Laboratory Information Systems; Clinical Medicine; Collaborations; Communication; Computer software; Consultations; Core Facility; Counseling; Data; Data Reporting; Databases; Development; Disease; Dose; Educational workshop; Ensure; Environmental Exposure; Environmental Health; Epidemiologist; Epidemiology; Exposure to; Faculty; Feedback; Fostering; Freezing; Funding; Genus Tagetes; Goals; Grant; Health; Hemolysis; Human; Human Development; Human Resources; Infrastructure; Institution; Label; Laboratories; Leadership; Life Cycle Stages; Life course epidemiology; Link; Liquid substance; Management Information Systems; Measures; Medical; Medicine; Metadata; Metals; Methodology; Methods; Mission; Modeling; Modernization; Nutritional; Occupations; Online Systems; Organization administrative structures; Parents; Participant; Peer Review; Pharmaceutical Chemistry; Phenotype; Physicians; Plasma; Play; Population; Predisposition; Preparation; Procedures; Process; Protocols documentation; Publications; Quality Control; Recommendation; Reporting; Research; Research Design; Research Personnel; Resources; Robotics; Route; Running; Sampling; Scientist; Services; Specimen; Statistical Data Interpretation; Stress; Structure; Study Subject; System; Technology; Testing; Time; Tooth structure; Toxicology; United States National Institutes of Health; Urine; Work; arm; biomarker development; data centers; data management; design; experience; flexibility; gene environment interaction; improved; indexing; innovation; instrument; instrumentation; interest; meetings; multidisciplinary; novel; nutrition; obesogen; operation; outreach; prevent; programs; quality assurance; social; software systems; specific biomarkers; success; targeted biomarker; trait; user-friendly

Project Summary: Administrative Core The Administrative Core is the overarching organizational unit and serves as the main communication arm of the Mount Sinai Targeted HHEAR Lab Hub, working directly with the HHEAR Coordinating Center (CC), Data Center (DC) and NIH program staff. We collaborate and communicate with the other Lab Hubs on QA/QC programs including proficiency testing, common QC pools, technical replicates, blinded duplicates, and methods to minimize batch effects and inter-lab variability, issues for which our team played key roles in the first grant cycle of CHEAR. We coordinate internally to maximize efficiency and can nimbly alter our priorities as directed by the CC (i.e. if specific biomarkers are needed based on demand). We organize weekly Steering Committee (SC) meetings of the Hub to coordinate intra-Hub work flow including receipt of sample shipments, re-labeling, tracking, and entry in to our laboratory information management system (LIMS). We organize PI/Client consultation meetings in which we review the parent study for design, sample specimen availability/quality, study subject exposure scenarios, health phenotypes, and requested types of chemicals exposures to be measured. We then make recommendations that best fit the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to conducting assay analysis. We also track the progress of on-going jobs and generate regular reports to the Coordinating Center, Data Center and NIH program. We coordinate data reporting with the HHEAR Data Center (DC), ensuring that our databases are properly formatted and contain the appropriate metadata. We also collaborate with the DC and Client/PI in the interpretation of results, (i.e. how hemolysis may impact levels of metals in plasma, which chemicals measured in urine are candidate obesogens etc.) and the statistical analysis of exposure/phenotype relationships. We organize and implement an annual Lab Hub workshop that engages existing and potential clients in Exposure assay methodologies. We were the only Lab Hub to organize such a meeting under CHEAR which was themed on exposomics and drew 200 scientific participants. We use a web based LIMS interface for tracking job progress through the Lab Hub system and to assess QA/QC in real time during analysis. In sum, we 1) coordinate communication internally within the Lab Hub and externally with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are followed rigorously; 3) maintain a LIMS that is user friendly, facilitates sample tracking, prevents mismatches between samples and results, and integrates with the needs of the Data Center; 4) provide scientific consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure that feedback communication occurs between Clients and Resources/Cores and that this information is relayed transparently to the CC and NIH and 6) ensure transparent fiscal management of the Tageted Lab Hub program.

项目摘要：行政核心 行政核心是支配性的组织单位，并作为 西奈山目标HHEAR实验室中心，直接与HHEAR协调中心（CC），数据 中心（DC）和NIH项目工作人员。我们与其他实验室中心在QA/QC方面进行合作和沟通 项目包括能力验证、通用QC样本池、技术重复、设盲重复，以及 最大限度地减少批次效应和实验室间变异性的方法，我们的团队在这些问题上发挥了关键作用。 第一个赠款周期。我们内部协调以最大限度地提高效率，并可以灵活地改变我们的优先事项 根据CC的指示（即，如果根据需求需要特定的生物标志物）。我们组织每周督导 中心的委员会（SC）会议，以协调中心内部的工作流程，包括接收样品运输， 重新贴标、跟踪并输入我们的实验室信息管理系统（LIMS）。我们组织 PI/客户咨询会议，我们在会上审查母研究的设计、样本 可用性/质量、研究受试者暴露情景、健康表型和要求的化学品类型 曝光量要测量。然后，我们提出最适合PI/客户目标的建议， 在进行检测分析之前，解决可能限制可行性的任何科学或技术问题。我们 还跟踪正在进行的作业的进度，并向协调中心、数据中心和 NIH计划。我们与HHEAR数据中心（DC）协调数据报告，确保我们的 数据库被适当地格式化并且包含适当的元数据。我们还与DC合作， 客户/PI解释结果（即溶血如何影响血浆中的金属水平， 尿液中检测到的化学物质是潜在的致肥胖物质等）暴露/表型的统计分析 关系。我们组织和实施年度实验室中心研讨会， 暴露分析方法的客户。我们是唯一一个在2015年组织这样一次会议的实验室中心。 CHEMICAL以生物学为主题，吸引了200名科学参与者。我们使用基于Web的LIMS 通过Lab Hub系统跟踪工作进度的界面，并在过程中真实的实时评估QA/QC 分析.总之，我们1）协调实验室中心内部的沟通和与外部的沟通， 协调中心、数据中心、PI/客户和NIH计划; 2）制定程序、方案和 系统检查，以确保样品流向正确的资源/核心，并遵循QA/QC方案 3）维护用户友好的LIMS，便于样品跟踪，防止 样本和结果，并与数据中心的需求相结合; 4）提供科学咨询 为PI/客户提供服务，最大限度地提高其研究结果的信息和质量; 5）确保反馈 在客户端和资源/核心之间发生通信，并且该信息被透明地中继 6）确保Tageted Lab Hub计划的透明财务管理。