Administrative Core

行政核心

• 批准号: 10660987
• 负责人: Robert O Wright
• 金额: $ 50.13万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10660987
• 关键词: Acceleration; Address; Age; Analytical Chemistry; Automation; Bioinformatics; Biological Assay; Biological Markers; Biology; Blinded; Budgets; Chemical Exposure; Chemicals; Child Health; Client; Clinical Chemistry; Clinical Laboratory Information Systems; Clinical Medicine; Collaborations; Communication; Computer software; Consultations; Core Facility; Counseling; Data; Data Reporting; Databases; Development; Disease; Dose; Educational workshop; Ensure; Environmental Exposure; Environmental Health; Epidemiologist; Epidemiology; Exposure to; Faculty; Feedback; Fostering; Freezing; Funding; Genus Tagetes; Goals; Grant; Health; Hemolysis; Human; Human Development; Human Resources; Infrastructure; Institution; Label; Laboratories; Leadership; Life Cycle Stages; Life course epidemiology; Link; Liquid substance; Management Information Systems; Measures; Medical; Medicine; Metadata; Metals; Methodology; Methods; Mission; Modeling; Modernization; Nutritional; Occupations; Online Systems; Organization administrative structures; Parents; Participant; Peer Review; Pharmaceutical Chemistry; Phenotype; Physicians; Plasma; Play; Population; Predisposition; Preparation; Procedures; Process; Protocols documentation; Publications; Quality Control; Recommendation; Reporting; Research; Research Design; Research Personnel; Resources; Robotics; Route; Running; Sampling; Scientist; Services; Specimen; Statistical Data Interpretation; Stress; Structure; Study Subject; System; Technology; Testing; Time; Tooth structure; Toxicology; United States National Institutes of Health; Urine; Work; arm; biomarker development; data centers; data management; design; experience; flexibility; gene environment interaction; improved; indexing; innovation; instrument; instrumentation; interest; meetings; multidisciplinary; novel; nutrition; obesogen; operation; outreach; prevent; programs; quality assurance; social; software systems; specific biomarkers; success; targeted biomarker; trait; user-friendly

Project Summary: Administrative Core The Administrative Core is the overarching organizational unit and serves as the main communication arm of the Mount Sinai Targeted HHEAR Lab Hub, working directly with the HHEAR Coordinating Center (CC), Data Center (DC) and NIH program staff. We collaborate and communicate with the other Lab Hubs on QA/QC programs including proficiency testing, common QC pools, technical replicates, blinded duplicates, and methods to minimize batch effects and inter-lab variability, issues for which our team played key roles in the first grant cycle of CHEAR. We coordinate internally to maximize efficiency and can nimbly alter our priorities as directed by the CC (i.e. if specific biomarkers are needed based on demand). We organize weekly Steering Committee (SC) meetings of the Hub to coordinate intra-Hub work flow including receipt of sample shipments, re-labeling, tracking, and entry in to our laboratory information management system (LIMS). We organize PI/Client consultation meetings in which we review the parent study for design, sample specimen availability/quality, study subject exposure scenarios, health phenotypes, and requested types of chemicals exposures to be measured. We then make recommendations that best fit the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to conducting assay analysis. We also track the progress of on-going jobs and generate regular reports to the Coordinating Center, Data Center and NIH program. We coordinate data reporting with the HHEAR Data Center (DC), ensuring that our databases are properly formatted and contain the appropriate metadata. We also collaborate with the DC and Client/PI in the interpretation of results, (i.e. how hemolysis may impact levels of metals in plasma, which chemicals measured in urine are candidate obesogens etc.) and the statistical analysis of exposure/phenotype relationships. We organize and implement an annual Lab Hub workshop that engages existing and potential clients in Exposure assay methodologies. We were the only Lab Hub to organize such a meeting under CHEAR which was themed on exposomics and drew 200 scientific participants. We use a web based LIMS interface for tracking job progress through the Lab Hub system and to assess QA/QC in real time during analysis. In sum, we 1) coordinate communication internally within the Lab Hub and externally with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are followed rigorously; 3) maintain a LIMS that is user friendly, facilitates sample tracking, prevents mismatches between samples and results, and integrates with the needs of the Data Center; 4) provide scientific consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure that feedback communication occurs between Clients and Resources/Cores and that this information is relayed transparently to the CC and NIH and 6) ensure transparent fiscal management of the Tageted Lab Hub program.

项目概要：行政核心 行政核心是总体组织单位，是主要的沟通部门 西奈山目标 HHEAR 实验室中心，直接与 HHEAR 协调中心 (CC) 合作，数据 中心 (DC) 和 NIH 项目工作人员。我们与其他实验室中心就 QA/QC 进行协作和沟通 计划包括能力验证、通用质量控制池、技术重复、盲法重复和 最小化批次效应和实验室间差异的方法，我们的团队在解决这些问题方面发挥了关键作用 CEAR 的第一个资助周期。我们进行内部协调以最大限度地提高效率，并可以灵活地改变我们的优先事项 按照 CC 的指示（即，如果根据需求需要特定的生物标志物）。我们每周组织指导 中心委员会 (SC) 会议，协调中心内部工作流程，包括接收样品货物、 重新标记、跟踪并输入我们的实验室信息管理系统 (LIMS)。我们组织 PI/客户咨询会议，我们在会上审查母公司研究的设计、样本 可用性/质量、研究对象暴露场景、健康表型和所需的化学品类型 要测量的暴露量。然后，我们提出最适合 PI/客户目标的建议，同时 在进行测定分析之前解决可能限制可行性的任何科学或技术问题。我们 还跟踪正在进行的工作的进度，并定期向协调中心、数据中心生成报告 和 NIH 计划。我们与 HHEAR 数据中心 (DC) 协调数据报告，确保我们的 数据库格式正确并包含适当的元数据。我们还与 DC 和 客户/PI 解释结果（即溶血如何影响血浆中的金属水平，这 尿液中测得的化学物质是候选致肥胖物质等）以及暴露/表型的统计分析 关系。我们组织并举办年度实验室中心研讨会，吸引现有和潜在的人员参与 暴露测定方法学的客户。我们是唯一组织此类会议的实验室中心 CHEAR 以暴露组学为主题，吸引了 200 名科学参与者。我们使用基于网络的 LIMS 用于通过 Lab Hub 系统跟踪工作进度并在工作期间实时评估 QA/QC 的界面 分析。总之，我们 1) 协调实验室中心内部的通信以及与外部的通信 协调中心、数据中心、PI/客户和 NIH 项目； 2) 制定程序、协议和 系统检查以确保样品流向正确的资源/核心并遵循 QA/QC 协议 严格地； 3) 维护一个用户友好的LIMS，促进样品跟踪，防止之间的不匹配 样本和结果，并与数据中心的需求相结合； 4）提供科学咨询 为 PI/客户提供服务，最大限度地提高其研究结果的信息和质量； 5）确保反馈 通信发生在客户端和资源/核心之间，并且该信息是透明中继的 向 CC 和 NIH 提供信息，6) 确保目标实验室中心计划的财务管理透明。