Mount Sinai CHEAR Laboratory Network Hub Administrative Core

项目摘要：行政核心 行政核心是我们的首要组织单位，并作为主要的通信手臂， 西奈山实验室中心，直接与CHEMICAL协调中心（CC）和NIH项目工作人员合作。 我们将与其他实验室中心就QA/QC开发进行合作和沟通。统筹推进 内部，以最大限度地提高效率，并将改变我们的优先事项，由CC（即，如果领域的化学 分析专业化发展或需要新的生物标志物）。我们将组织每月一次的执行指导 资源/核心领导人和其他关键人员的委员会（ESC）会议，以协调中心内部 工作流程，包括计划接收样品运输，重新贴标，跟踪和进入我们的实验室 信息管理系统（LIMS）。ESC会议将包括CC工作人员，以帮助沟通 特定Hub组件的特殊程序需求（例如，开发用于特定Hub组件的测定的程序需求） 新兴的感兴趣的化学品可能作为对开发核心和目标资源的指示而出现）。 我们将组织PI/客户咨询会议，在会上我们将审查母研究的设计、样本 样本可用性、表型和要求测量的暴露类型。然后我们将 最适合PI/客户目标的建议，同时解决可能 在进行含量测定分析之前限制可行性。我们还将跟踪正在进行的工作的进展情况， 定期向协调中心和NIH项目提交报告。我们将协调数据报告， CHEMICAL数据中心（DC），确保我们的数据库格式正确，并包含适当的 元数据.我们还将与DC和客户/PI合作解释结果（即QA/QC问题） 以及暴露/表型关系的统计分析。组织实施年度 实验室中心研讨会，将吸引现有和潜在的客户在暴露生物学分析方法， 通知用户如何访问我们基于Web的LIMS界面，以便通过Lab Hub跟踪作业进度 系统总之，我们将1）协调实验室中心内部的沟通以及与 协调中心、数据中心、PI/客户和NIH计划; 2）制定程序、方案和 系统检查，以确保样品流向正确的资源/核心，并遵循QA/QC方案 3）维护一个用户友好的LIMS系统，便于样品跟踪，防止错配 与数据中心的需求相结合; 4）提供科学的 为PI/客户提供咨询服务，最大限度地提高其研究结果的信息和质量; 5）确保 在客户端和资源/核心之间发生反馈通信，并且该信息被中继 对CC和NIH透明，6）确保实验室中心计划的透明财务管理。

Project Summary: Administrative Core The Administrative Core is our overarching organizational unit and serves as the main communication arm of the Mount Sinai Lab Hub, working directly with the CHEAR Coordinating Center (CC) and NIH program staff. We will collaborate and communicate with the other Lab Hubs on QA/QC development. We will coordinate internally to maximize efficiency and will alter our priorities as directed by the CC (i.e. if areas of chemical analysis specialization develop or new biomarkers are needed). We will organize monthly Executive Steering Committee (ESC) meetings of the Resource/Core Leaders and other key personnel to coordinate intra-Hub work flow including planning receipt of sample shipments, re-labeling, tracking, and entry to our laboratory information management system (LIMS) system. ESC meetings will include CC staff to aid in communication of special programmatic needs to specific Hub components (e.g. a programmatic need to develop an assay for an emerging chemical of interest may arise as a directive to the Developmental Core and Targeted Resource). We will organize PI/Client consultation meetings in which we review the parent study for design, sample specimen availability, phenotypes, and requested types of exposures to be measured. We will then make recommendations to best fit the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to conducting assay analysis. We will also track the progress of on-going jobs and generate regular reports to the Coordinating Center and to NIH program. We will coordinate data reporting with the CHEAR Data Center (DC), ensuring that our databases are properly formatted and contain the appropriate metadata. We will also collaborate with the DC and Client/PI in the interpretation of results (i.e. QA/QC issues) and the statistical analysis of exposure/phenotype relationships. We will organize and implement an annual Lab Hub workshop that will engage existing and potential clients in Exposure Biology assay methodologies and inform users on how to access our web based LIMS interface for tracking job progress through the Lab Hub system. In sum, we will 1) coordinate communication internally within the Lab Hub and externally with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are followed rigorously; 3) maintain a LIMS system that is user friendly, facilitates sample tracking, prevents mismatches between samples and results, and integrates with the needs of the Data Center; 4) provide scientific consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure that feedback communication occurs between Clients and Resources/Cores and that this information is relayed transparently to the CC and NIH and 6) ensure transparent fiscal management of the Lab Hub program.