Lysosomal dysfunction as an inhibitor of vitamin B12 utilisation in neurodegenerative diseases

溶酶体功能障碍作为神经退行性疾病中维生素 B12 利用的抑制剂

• 批准号: nhmrc : 1065982
• 负责人: Prof Brett Garner
• 金额: $ 37万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/lysosomal-dysfunction-an-neurodegenerative-diseases/455214
• 关键词: Lysosomal; dysfunction; inhibitor; vitamin; B12

Vitamin B12 is required for red blood cell formation, DNA synthesis and normal neurological function. B12 deficiency contributes to age-related cognitive decline and Alzheimer’s disease. This research will provide important new information regarding the ageing process and the impact that brain changes associated with ageing and Alzheimer's disease have on B12 metabolism. It will provide important information related to the therapeutic potential of B12.

维生素B12是红细胞形成、DNA合成和正常神经功能所必需的。B12缺乏会导致与年龄相关的认知能力下降和阿尔茨海默病。这项研究将为衰老过程以及与衰老和阿尔茨海默病相关的大脑变化对B12代谢的影响提供重要的新信息。它将提供有关B12治疗潜力的重要信息。