Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment.
Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment.
批准号:
nhmrc : 1109831
负责人:
Prof Brett Garner
金额:
$47.43万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2020-12-31
中文摘要
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英文摘要
Alzheimer’s disease (AD) is the major cause of dementia and is currently without a curative treatment. An understanding of the pathways that lead to AD is urgently required to develop approaches for treatments. We have discovered new pathways by which proteins called ApoE and ABCA7 control AD. We now aim to define precisely how these proteins work in the brain and use this information to develop therapeutic approaches to treat AD in humans.
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Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment.
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批准号:nhmrc : GNT1109831
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项目类别:Research Fellowships
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资助金额:$68.8万
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财政年份:2016
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负责人:Prof Brett Garner
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依托单位:
Lysosomal dysfunction as an inhibitor of vitamin B12 utilisation in neurodegenerative diseases
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批准号:nhmrc : 1065982
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项目类别:Project Grants
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资助金额:$37.0万
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负责人:Prof Brett Garner
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依托单位:
A novel intracellular roadblock to cobalamin utilization in ageing and Alzheimer�s disease
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批准号:nhmrc : 1047848
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项目类别:NHMRC Project Grants
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资助金额:$0.75万
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财政年份:2013
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负责人:Prof Brett Garner
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依托单位:
Cellular effects of glucocerebrosidase (GBA) mutations in Lewy body diseases
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批准号:nhmrc : 1008307
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项目类别:NHMRC Project Grants
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资助金额:$35.0万
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财政年份:2011
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负责人:Prof Brett Garner
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依托单位:
Targeting brain lipid homeostasis to treat Alzheimer's disease
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批准号:FT0991986
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项目类别:ARC Future Fellowships
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资助金额:$56.26万
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财政年份:2010
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负责人:Prof Brett Garner
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 630445
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项目类别:NHMRC Research Fellowships
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资助金额:$24.07万
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财政年份:2010
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负责人:Prof Brett Garner
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依托单位:
Cholesterol efflux apolipoprotein-E and glycobiology
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批准号:nhmrc : 350810
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项目类别:Career Development Fellowships
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资助金额:$30.24万
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财政年份:2005
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负责人:Prof Brett Garner
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依托单位:
Nuclear Trafficking of Apolipoprotein-E
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批准号:DP0557295
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资助金额:$22.55万
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财政年份:2005
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负责人:Prof Brett Garner
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依托单位:
A Glycobiology Facility for Glycoconjugate Analysis and Oligosaccharide Sequencing
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批准号:LE0454209
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$8.42万
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负责人:Prof Brett Garner
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Function of glycosphingolipid-enriched microdomains in the macrophage foam cell
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批准号:nhmrc : 189990
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项目类别:Early Career Fellowships
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资助金额:$10.95万
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财政年份:2002
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负责人:Prof Brett Garner
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依托单位:
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