Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment.

定义 ABCA7 和 apoE 控制阿尔茨海默病风险的机制。

• 批准号: nhmrc : 1109831
• 负责人: Prof Brett Garner
• 金额: $ 47.43万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-mechanisms-abca7-prevention-treatment/663098
• 关键词: Defining; mechanisms; ABCA7; apoE; control

Alzheimer’s disease (AD) is the major cause of dementia and is currently without a curative treatment. An understanding of the pathways that lead to AD is urgently required to develop approaches for treatments. We have discovered new pathways by which proteins called ApoE and ABCA7 control AD. We now aim to define precisely how these proteins work in the brain and use this information to develop therapeutic approaches to treat AD in humans.

阿尔茨海默氏病（AD）是痴呆的主要原因，并且目前没有治愈性治疗。迫切需要了解导致AD的途径，以开发治疗方法。我们已经发现了新的途径，通过这些途径，ApoE和ABCA 7蛋白控制AD。我们现在的目标是精确定义这些蛋白质在大脑中的工作方式，并利用这些信息开发治疗人类AD的治疗方法。