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A novel intracellular roadblock to cobalamin utilization in ageing and Alzheimer�s disease

A novel intracellular roadblock to cobalamin utilization in ageing and Alzheimer�s disease
衰老和阿尔茨海默病中钴胺素利用的新型细胞内障碍
批准号:
nhmrc : 1047848
负责人:
Prof Brett Garner
金额:
$0.75万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2013-12-31

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中文摘要
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英文摘要
Vitamin B12 is required for red blood cell formation, DNA synthesis and normal neurological function. B12 deficiency contributes to age-related cognitive decline and Alzheimer�s disease. This research will provide important new information regarding the ageing process and the impact that brain changes associated with ageing and Alzheimer's disease have on B12 metabolism. It will provide important information related to the therapeutic potential of B12.
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Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment.
  • 批准号:
    nhmrc : GNT1109831
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $68.8万
  • 财政年份:
    2016
  • 负责人:
    Prof Brett Garner
  • 依托单位:
Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment.
  • 批准号:
    nhmrc : 1109831
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $47.43万
  • 财政年份:
    2016
  • 负责人:
    Prof Brett Garner
  • 依托单位:
Lysosomal dysfunction as an inhibitor of vitamin B12 utilisation in neurodegenerative diseases
  • 批准号:
    nhmrc : 1065982
  • 项目类别:
    Project Grants
  • 资助金额:
    $37.0万
  • 财政年份:
    2014
  • 负责人:
    Prof Brett Garner
  • 依托单位:
Cellular effects of glucocerebrosidase (GBA) mutations in Lewy body diseases
  • 批准号:
    nhmrc : 1008307
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $35.0万
  • 财政年份:
    2011
  • 负责人:
    Prof Brett Garner
  • 依托单位:
国内基金
海外基金
TAG1/APP信号通路调控的miRNA及其在神经前体细胞增殖和分化中的作用机制
  • 批准号:
    31171313
  • 项目类别:
    面上项目
  • 资助金额:
    60.0万元
  • 批准年份:
    2011
  • 负责人:
    马全红
  • 依托单位:
吸入性全身麻醉药致发育神经元毒性的受体-细胞内钙稳态阶段特异性机制及干预研究
  • 批准号:
    30772086
  • 项目类别:
    面上项目
  • 资助金额:
    30.0万元
  • 批准年份:
    2007
  • 负责人:
    罗爱林
  • 依托单位: