Nuclear Trafficking of Apolipoprotein-E

载脂蛋白-E 的核贩运

• 批准号: DP0557295
• 负责人: Prof Brett Garner
• 金额: $ 22.55万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2008-08-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0557295
• 关键词: Nuclear; Trafficking; Apolipoprotein

Apolipoprotein-E (apoE) regulates specific age-related neurodegenerative and cardiovascular diseases. The role of apoE in these disorders is unclear. This project will benefit our community by providing the basic cell biology knowledge required to understand disease mechanisms and ultimately provide avenues for better treatments. Aspects of the project will focus on the modification of apoE by carbohydrates and the interaction of apoE with cellular carbohydrate-containing structures. The importance of carbohydrates in the regulation of cellular and protein function is increasingly recognised and forms a foundation for the rapidly expanding discipline of glycobiology. This project will strengthen Australia's glycobiology research capacity.

载脂蛋白-E (apoE) 调节特定的与年龄相关的神经退行性疾病和心血管疾病。 apoE 在这些疾病中的作用尚不清楚。该项目将通过提供了解疾病机制所需的基本细胞生物学知识并最终为更好的治疗提供途径，使我们的社区受益。该项目的重点是碳水化合物对 apoE 的修饰以及 apoE 与细胞含碳水化合物结构的相互作用。碳水化合物在细胞和蛋白质功能调节中的重要性日益得到认识，并为迅速发展的糖生物学学科奠定了基础。该项目将加强澳大利亚的糖生物学研究能力。