Impact of prenatal insecticide exposure on neurodevelopmental trajectories in a Thai birth cohort: building exposure science and neurodevelopmental research capacity in Thailand

产前杀虫剂暴露对泰国出生队列神经发育轨迹的影响：在泰国建立暴露科学和神经发育研究能力

• 批准号: 9685733
• 负责人: Dana Boyd Barr
• 金额: $ 15.66万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9685733
• 关键词: Address; Affect; Age; Anger; Animals; Assessment tool; Attention; Awareness; Biological Markers; Birth; Blood specimen; Child; Cognition; Cognitive; Cohort Studies; Collaborations; Communities; Core Facility; Country; Dengue; Developing Countries; Development; Educational Materials; Emotional; Emotions; Environmental Exposure; Exhibits; Exposure to; Farming environment; Frequencies; Fright; Funding; General Population; Grant; Health; Infant; Informal Social Control; Insecticides; International; Laboratories; Language; Life; Link; Measures; Memory; Mothers; Motor; Neurites; Neurologic; Neurotoxins; Observational Study; Organophosphates; Outcome; Pathway interactions; Pesticides; Predisposition; Pregnancy; Pregnancy Trimesters; Pregnant Women; Prevention; Process; Public Health Applications Research; Publications; Questionnaires; Recommendation; Regulation; Research; Research Personnel; Rice; Risk Assessment; Sampling; Science; Seasons; Second Pregnancy Trimester; Speed; Testing; Thailand; Toxic effect; Umbilical Cord Blood; Universities; Urine; Visual; Visual attention; Woman; Work; World Health Organization; Writing; adverse outcome; base; cognitive function; cohort; community based participatory research; design; early childhood; emotion regulation; fetal insecticide exposure; fruits and vegetables; habituation; indexing; infancy; innovation; laboratory facility; memory recall; model development; nervous system development; neurobehavioral; neurodevelopment; neurotoxic; neurotoxicity; offspring; pesticide induced neurotoxicity; prenatal; prenatal exposure; pyrethroid; recruit; response; social

Project Summary Exposure to insecticides is ubiquitous in the developing world, where women who perform farming activities throughout pregnancy are routinely exposed. Although several birth cohort studies in the U.S. have shown persistent neurodevelopmental effects of prenatal organophosphate (OP) insecticide exposure, the neurodevelopmental pathways and timing of exposure leading to adverse outcomes is not clear. Thus, regulatory agencies have been reluctant to change risk assessment standards or provide specific recommendations about exposures to pregnant women. The proposed longitudinal birth cohort study in Thailand will: 1) build capacity of Thai researchers to develop innovative and competitive studies of pesticide related neurotoxicity 2) measure metabolites of OP and pyrethroid (PYR) insecticides during each trimester of pregnancy, and 3) evaluate the impact of prenatal OP (and PYR as exploratory analysis) insecticide exposure on neurodevelopmental trajectories from birth to age 3. In collaboration with Chulalongkorn University (CU) in central Thailand and Chiang Mai University (CMU) in northern Thailand, 300 pregnant women will be recruited. Eight serial urine samples, 4 serial blood samples, and umbilical cord blood will be collected during pregnancy to document temporally-resolved insecticide exposure during each trimester. The Brazelton Neurobehavioral Assessment Scale will be administered to offspring at birth followed by tests of visual attention, regulation of emotion, memory and inhibitory control to determine how the “cascade” of neurologic development ultimately affects overall cognitive function (e.g., Bayley-III). Capacity building activities include development of core analytic laboratory facilities at CMU and neurodevelopmental facilities at CU along with courses to promote grant writing and international scientific publications.

项目摘要 在发展中国家，接触杀虫剂无处不在，在那里进行农业活动的女性 整个怀孕通常会暴露出来。尽管在美国进行了几项出生队列研究 产前有机磷酸盐（OP）杀虫剂暴露的持续性神经发育作用， 神经发育途径和导致不良结果的暴露时间尚不清楚。那， 监管机构不愿改变风险评估标准或提供特定 关于接触孕妇的建议。拟议的纵向出生队列研究 泰国将：1）建立泰国研究人员的能力，以开发农药的创新和竞争性研究 相关神经毒性2）测量在每个三个月期间OP和拟除虫菊酯（Pyr）杀虫剂的代谢产物 怀孕和3）评估产前OP（和PYR作为探索性分析）杀虫剂暴露的影响 关于从出生到3岁的神经发育轨迹。与丘拉隆大学（CU）合作 泰国北部泰国中部和清迈大学（CMU）将招募300名孕妇。 怀孕期间将收集八个连续尿液样本，4个连续血样品和脐带血 记录每个三个月暂时解决的杀虫剂的暴露。巴西神经行为 评估量表将在出生时对后代进行，然后进行视觉注意的测试，调节 情绪，记忆和抑制控制，以确定神经系统发展的“级联”最终如何 影响总体认知功能（例如Bayley-III）。能力建设活动包括开发核心 CMU和CU神经发育设施的分析实验室设施以及促进的课程 赠款写作和国际科学出版物。