PBDE Body Burdens, House Dust Concentrations and Associations with Thyroid Hormon

PBDE 身体负担、室内灰尘浓度以及与甲状腺激素的关联

• 批准号: 8028963
• 负责人: Dana Boyd Barr
• 金额: $ 31.64万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-15 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8028963
• 关键词: 5 year old; Adult; Age; Albumins; Anesthesia procedures; Animals; Antibodies; Anxiety; Binding; Blood; Blood specimen; Body Burden; Child; Childhood; Collaborations; Detection; Development; Dust; Ear; Endocrine; Endocrine disruption; Endocrine system; Endocrinologist; Environment; Epidemiologic Studies; Epidemiologist; Epidemiology; Exposure to; Flame Retardants; General Anesthesia; Globulins; Health; Home environment; Homeostasis; House Dust; Housing; Human; Human body; Individual; Investigation; Iodide Peroxidase; Laboratories; Measures; Operative Surgical Procedures; Participant; Pathway interactions; Persons; Pilot Projects; Public Health Schools; Reporting; Research Project Grants; Resources; Reverse Triiodothyronine; Route; Sampling; Scientist; Serum; Source; Thyroglobulin antibody; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyroid stimulating immunoglobulins; Thyrotropin; Thyroxine; Tube; Tympanostomy; age group; cohort; consumer product; early childhood; early life exposure; phenyl ether; uptake

DESCRIPTION (provided by applicant): This developmental research project explores relationships among polybrominated diphenyl ether (PBDE) flame retardant concentrations in house dust, PBDE body burdens, and circulating thyroid hormone levels in early childhood. The study is motivated by recent epidemiologic evidence of an association between PBDE serum levels and thyroid disruption in adults, and limited but compelling reports of substantially higher PBDE body burdens in children compared to adults. In a pilot study of 80 children, we seek to establish the feasibility of investigating relationships between PBDE exposure routes, serum concentrations and thyroid function in a larger epidemiologic study, while building the in-house laboratory capacity to measure the range of PBDE congeners in serum and house dust. Serum samples will be obtained from a cohort of 80 children between 2 and 5 years of age who are under general anesthesia for ear tube surgery (myringotomy). Serum will be analyzed for an expanded panel of thyroid markers as well as congener-specific concentrations of PBDEs. In a subset of 20 study participants, house dust will be collected from the main activity room of the home and analyzed for PBDE concentrations. The study aims are to (a) build laboratory capacity to measure congener- specific PBDE concentrations in human serum and house dust (b) characterize the distribution of serum concentrations of PBDEs in a cohort of 80 children between 2 and 5 years, (c) explore associations between serum levels of PBDEs and thyroid hormones in young children, and (d) explore correlations between PBDEs concentrations in house dust and PBDE serum levels in young children to assess dust as a major route of exposure. Collaboration between analytical chemists, epidemiologists, exposure scientists, and pediatric endocrinologists will facilitate investigation of PBDEs from sources in the environment to human body burdens to effects on the endocrine system in a vulnerable and understudied age group. Study findings will contribute to our understanding of the body burden, endocrine effects and exposure routes of brominated flame retardants in early childhood, and will help guide the direction of future research efforts targeting early-life exposures to PBDEs and endocrine disruption. PUBLIC HEALTH RELEVANCE: Polybrominated diphenyl ethers (PBDEs) are flame retardant compounds added to a wide range of consumer products. Despite indications that children have substantially higher exposures to these compounds than adults, little is known about body burdens, exposure pathways and health effects of PBDEs in young children. These questions are investigated in a pilot cohort of 80 children ages 2 to 5 years.

描述（由申请人提供）：该发展研究项目探讨了多溴二苯基醚（PBDE）在房屋灰尘，PBDE体内负担和循环甲状腺激素水平的二苯基醚（PBDE）燃料浓度之间的关系。这项研究是由最近的流行病学证据激发的，表明成人PBDE血清水平与甲状腺破坏之间存在关联，并且与成人相比，儿童的PBDE身体负担更高但令人信服的报道有限。在一项对80名儿童的试点研究中，我们试图在一项更大的流行病学研究中建立研究PBDE暴露途径，血清浓度和甲状腺功能之间关系的可行性，同时建立了内部实验室的能力，以衡量PBDE同种植物在血清中和房屋灰尘中的范围。血清样品将从2至5岁之间的80名儿童组成的队列中获得，这些儿童受到耳管手术的全身麻醉（骨髓切开术）。血清将分析扩大的甲状腺标记和同类物特异性PBDE的面板。在20名研究参与者的子集中，将从家庭的主要活动室收集房屋灰尘，并分析PBDE浓度。该研究的目的是（a）建立实验室的能力，以测量人血清和房屋灰尘中的特定PBDE浓度（b）（b）的特征是在2至5岁之间的80名儿童中血清中PBDES浓度的分布，（c）探索PBDES和PBDES和甲状腺甲型之间的血清之间的相关性，以及PBERS的浓度，以及PBERS的脉冲相关（D）。幼儿的血清水平评估灰尘是主要暴露途径。分析化学家，流行病学家，暴露科学家和小儿内分泌学家之间的合作将有助于研究来自环境中的PBDE，以在易受伤害且被忽视的年龄段的内分泌系统中对人体负担产生对内分泌系统的影响。研究结果将有助于我们对幼儿时期溴化阻燃剂的身体负担，内分泌效应和暴露途径的理解，并将帮助指导未来的研究工作的方向，以针对早期生活暴露于PBDES和内分泌干扰。 公共卫生相关性：多溴二苯基醚（PBDES）是添加到广泛的消费产品中的阻燃化合物。尽管迹象表明儿童对这些化合物的暴露率要比成人高得多，但对幼儿PBDE的身体负担，暴露途径和健康影响知之甚少。这些问题是在80名2至5岁儿童的飞行员队列中调查的。