Impact of prenatal insecticide exposure on neurodevelopmental trajectories in a Thai birth cohort: building exposure science and neurodevelopmental research capacity in Thailand

产前杀虫剂暴露对泰国出生队列神经发育轨迹的影响：在泰国建立暴露科学和神经发育研究能力

• 批准号: 9768202
• 负责人: Dana Boyd Barr
• 金额: $ 67.31万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9768202
• 关键词: Address; Affect; Age; Anger; Animals; Assessment tool; Attention; Awareness; Biological Markers; Birth; Blood specimen; Child; Cognition; Cognitive; Cohort Studies; Collaborations; Communities; Core Facility; Country; Dengue; Developing Countries; Development; Educational Materials; Emotional; Emotions; Environmental Exposure; Exhibits; Exposure to; Farming environment; Frequencies; Fright; Funding; General Population; Grant; Health; Infant; Informal Social Control; Insecticides; International; Laboratories; Language; Life; Link; Measures; Memory; Mothers; Motor; Neurites; Neurologic; Neurotoxins; Observational Study; Organophosphates; Outcome; Pathway interactions; Pesticides; Predisposition; Pregnancy; Pregnancy Trimesters; Pregnant Women; Prevention; Process; Public Health Applications Research; Publications; Questionnaires; Recommendation; Regulation; Research; Research Personnel; Rice; Risk Assessment; Sampling; Science; Seasons; Second Pregnancy Trimester; Speed; Testing; Thailand; Toxic effect; Umbilical Cord Blood; Universities; Urine; Visual; Visual attention; Woman; Work; World Health Organization; Writing; adverse outcome; base; cognitive function; cohort; community based participatory research; design; early childhood; emotion regulation; fetal insecticide exposure; fruits and vegetables; habituation; indexing; infancy; innovation; laboratory facility; memory recall; model development; nervous system development; neurobehavioral; neurodevelopment; neurotoxic; neurotoxicity; offspring; pesticide induced neurotoxicity; prenatal; prenatal exposure; pyrethroid; recruit; response; social

Project Summary Exposure to insecticides is ubiquitous in the developing world, where women who perform farming activities throughout pregnancy are routinely exposed. Although several birth cohort studies in the U.S. have shown persistent neurodevelopmental effects of prenatal organophosphate (OP) insecticide exposure, the neurodevelopmental pathways and timing of exposure leading to adverse outcomes is not clear. Thus, regulatory agencies have been reluctant to change risk assessment standards or provide specific recommendations about exposures to pregnant women. The proposed longitudinal birth cohort study in Thailand will: 1) build capacity of Thai researchers to develop innovative and competitive studies of pesticide related neurotoxicity 2) measure metabolites of OP and pyrethroid (PYR) insecticides during each trimester of pregnancy, and 3) evaluate the impact of prenatal OP (and PYR as exploratory analysis) insecticide exposure on neurodevelopmental trajectories from birth to age 3. In collaboration with Chulalongkorn University (CU) in central Thailand and Chiang Mai University (CMU) in northern Thailand, 300 pregnant women will be recruited. Eight serial urine samples, 4 serial blood samples, and umbilical cord blood will be collected during pregnancy to document temporally-resolved insecticide exposure during each trimester. The Brazelton Neurobehavioral Assessment Scale will be administered to offspring at birth followed by tests of visual attention, regulation of emotion, memory and inhibitory control to determine how the “cascade” of neurologic development ultimately affects overall cognitive function (e.g., Bayley-III). Capacity building activities include development of core analytic laboratory facilities at CMU and neurodevelopmental facilities at CU along with courses to promote grant writing and international scientific publications.

项目摘要 在发展中国家中，暴露于杀虫剂的妇女无处不在 整个怀孕的活动通常会暴露出来。虽然在 美国显示出产前有机磷酸盐（OP）的持续性神经发育作用 杀虫剂暴露，神经发育途径和暴露的时间导致广告 结果尚不清楚。那就是监管机构不愿改变风险评估 标准或提供有关孕妇暴露的具体建议。提议 泰国纵向出生队列研究将：1）泰国研究人员发展能力 对农药相关的神经毒性的创新和竞争研究2）OP的测量代谢物 在怀孕的每个三个月期间，拟除虫菊酯（PYR）杀虫剂，3）评估 产前OP（和PYR作为探索性分析）神经发育中的杀虫剂暴露 从出生到3岁的轨迹。与中央的丘拉隆大学（CU）合作 泰国泰国泰国和清迈大学（CMU）位于泰国北部，将有300名孕妇 招募。八个连环尿液样本，4个连续血样品和脐带血将是 在怀孕期间收集以记录每次暂时解决的杀虫剂的暴露 孕期。巴西神经行为评估量表将用于后代 生日，然后测试视觉注意，情绪调节，记忆和抑制性控制 确定神经系统发展的“级联”最终如何影响整体认知 功能（例如，贝利 - iii）。能力建设活动包括开发核心分析 CMU和CU神经发育设施的实验室设施以及促进的课程 赠款写作和国际科学出版物。