The 2019 Conference of the United States Human Proteome Organization (US HUPO)

项目摘要/摘要 我们请求为美国人类蛋白质组组织会议提供部分资金支持 HuPo)将在华盛顿特区/罗克维尔希尔顿酒店和行政会议中心举行 2019年3月3日至6日，马里兰州贝塞斯达/罗克维尔。这次会议是一次非常有价值的贡献。 到蛋白质组学的跨学科科学领域，特别关注该领域的当前技术 以及它们在解决与人类健康有关的生物和临床问题方面的应用。上所涵盖的主题 美国HuPo会议反映了涵盖 蛋白质组学领域，以及它们在解决复杂的生物医学问题和实现旨在 推进人类疾病的诊断、预后和治疗。会议的题目是《蛋白质组学》 生物学和医学的前沿“概括了技术(例如，质谱学， 生物信息学、临床/细胞分析)和蛋白质组学领域固有的生物发现。2019年 会议的联合组织者是Ileana Cristea(普林斯顿大学)、Steve Carr(远大学院)和David 芬约(纽约大学)。口头会议的主题经过精心挑选，为与会者提供了 接触最新的蛋白质组技术及其在生物医学研究问题中的应用 特别是在癌症、传染病、免疫、微生物组、老龄化和临床诊断和 化验。以生物学和临床为重点的口头陈述会议包括：生物和临床中的糖蛋白组学 医学，传染病，免疫和微生物组，癌症早期发现和预防， 代谢与疾病，健康与疾病中的蛋白质蛋白质组，衰老与神经疾病，以及 翻译后调节和信号传递。此外，专门讨论技术发展的会议 包括多组学、蛋白质组时空组织、技术进步、结构/化学 蛋白质组学和信息学：新兴/新方法。海报会议将提供一种不那么正式的形式 科学主题的陈述和讨论。有组织的社交活动将为进一步 与会者之间的讨论和协作网络。商务会议将提供一个开放的论坛来 听取美国HuPo的使命，并提供反馈。预计出席人数为350-400人，其中包括100- 150名学生/博士后。将特别努力招募少数群体和行业参与者，还 为年轻的调查人员提供一个场所，介绍他们的工作，通过“闪电”谈话等机制。 通过R13机制申请的资金将有助于支持少数族裔和青年调查员的参与 在会议上。还将提供短期课程和研讨会，对与会者进行高级培训 或者为讨论职业选择和其他及时的科学话题提供一个论坛。

PROJECT SUMMARY/ABSTRACT We request partial funding support for the Conference of the United States Human Proteome Organization (US HUPO) to be held at the Hilton Washington DC/Rockville Hotel & Executive Meeting Center in Bethesda/Rockville, MD on March 3-6, 2019. This meeting has established itself as a highly valued contribution to the interdisciplinary scientific field of proteomics, with a particular focus on current technologies in the field and their application to solving biological and clinical questions relevant to human health. The topics covered at the US HUPO conference reflect the multiple disciplines, strategies, and technologies encompassing the proteomics field, and their use to address complex biomedical problems and enable new discoveries aimed at advancing diagnosis, prognosis and treatment of human disease. The title of the conference, “Proteomics at the Frontiers of Biology and Medicine," encapsulates this interplay between technology (e.g. mass spectrometry, bioinformatics, clinical/cellular assays) and biological discovery inherent to the proteomics field. The 2019 conference co-organizers are Ileana Cristea (Princeton University), Steve Carr (Broad Institute), and David Fenyo (New York University). The topics of the oral sessions have been carefully selected to provide attendees exposure to the latest proteomic technologies and their application to biomedical research questions – in particular in the fields of cancer, infectious disease, immunity, microbiome, aging, and clinical diagnostics and assays. Oral presentation sessions with biological and clinical focus include: Glycoproteomics in Biology and Medicine, Infectious Diseases, Immunity and the Microbiome, Cancer Early Detection and Prevention, Metabolism and Disease, Protein Proteoforms in Health and Disease, Aging and Neurological Diseases, and Posttranslational Regulation and Signaling. Additionally, sessions dedicated to technology developments include Multi-Omics, Proteome Organization in Space and Time, Advances in Technology, Structural/Chemical Proteomics, and Informatics: Emerging/ New Approaches. Poster sessions will offer a less formal format for presentation and discussion of scientific topics. Organized social activities will provide opportunities for further discussion and collaborative networking between attendees. A Business Meeting will provide an open forum to hear about the mission of US HUPO and give feedback. Attendance is expected to be 350-400, including 100- 150 students/postdocs. A special effort will be made to recruit minority and industrial participants, and also provide a venue for young investigators to present their work – through mechanisms such as “lightning” talks. Funding requested through this R13 mechanism will help support minority and young investigator participation in the conference. Short courses and workshops will also be offered to either train attendees in advanced proteomic technologies or provide a forum for discussing career options and other timely scientific topics.