The 2019 Conference of the United States Human Proteome Organization (US HUPO)

项目概要/摘要 我们请求为美国人类蛋白质组组织（US）会议提供部分资金支持 HUPO）将在希尔顿华盛顿/罗克维尔酒店及行政会议中心举行， 2019年3月3日至6日，马里兰州贝塞斯达/罗克维尔。这次会议已成为一个高度宝贵的贡献 蛋白质组学的跨学科科学领域，特别关注该领域的现有技术 以及它们在解决与人类健康相关的生物学和临床问题中的应用。所涵盖的主题 美国HUPO会议反映了多学科，战略和技术，包括 蛋白质组学领域，及其用于解决复杂的生物医学问题，并使新的发现，旨在 推进人类疾病的诊断、预后和治疗。会议的标题是"蛋白质组学在 《生物学和医学前沿》概括了技术（如质谱法， 生物信息学、临床/细胞测定）和蛋白质组学领域固有的生物发现。2019年 会议的共同组织者是Ileana Cristea（普林斯顿大学），Steve卡尔（布罗德研究所）和大卫 Fenyo（纽约大学）。口头会议的主题已经精心挑选，以提供与会者 接触最新的蛋白质组学技术及其在生物医学研究问题中的应用-在 特别是在癌症、传染病、免疫、微生物组、衰老和临床诊断领域， 测定。生物学和临床重点的口头报告会议包括：生物学中的糖蛋白质组学和 医学，传染病，免疫和微生物组，癌症早期检测和预防， 代谢和疾病，蛋白质蛋白质在健康和疾病，衰老和神经系统疾病， 翻译后调节和信号转导。此外，专门讨论技术发展的会议 包括多组学、蛋白质组时空组织、技术进展、结构/化学 蛋白质组学和信息学：新兴/新方法。海报会议将提供一个不太正式的格式， 介绍和讨论科学主题。有组织的社会活动将提供进一步的机会， 与会者之间的讨论和协作网络。商务会议将提供一个开放的论坛， 了解美国HUPO的使命并给予反馈。预计出席人数为350 - 400人，其中包括100- 150名学生/博士后。将特别努力招募少数族裔和工业界的参与者， 通过"闪电"会谈等机制，为年轻调查人员提供展示其工作的场所。 通过这一R13机制申请的资金将有助于支持少数族裔和年轻研究人员的参与 在会议上。短期课程和研讨会也将提供给培训与会者在先进的 蛋白质组技术或提供一个论坛，讨论职业选择和其他及时的科学话题。

PROJECT SUMMARY/ABSTRACT We request partial funding support for the Conference of the United States Human Proteome Organization (US HUPO) to be held at the Hilton Washington DC/Rockville Hotel & Executive Meeting Center in Bethesda/Rockville, MD on March 3-6, 2019. This meeting has established itself as a highly valued contribution to the interdisciplinary scientific field of proteomics, with a particular focus on current technologies in the field and their application to solving biological and clinical questions relevant to human health. The topics covered at the US HUPO conference reflect the multiple disciplines, strategies, and technologies encompassing the proteomics field, and their use to address complex biomedical problems and enable new discoveries aimed at advancing diagnosis, prognosis and treatment of human disease. The title of the conference, “Proteomics at the Frontiers of Biology and Medicine," encapsulates this interplay between technology (e.g. mass spectrometry, bioinformatics, clinical/cellular assays) and biological discovery inherent to the proteomics field. The 2019 conference co-organizers are Ileana Cristea (Princeton University), Steve Carr (Broad Institute), and David Fenyo (New York University). The topics of the oral sessions have been carefully selected to provide attendees exposure to the latest proteomic technologies and their application to biomedical research questions – in particular in the fields of cancer, infectious disease, immunity, microbiome, aging, and clinical diagnostics and assays. Oral presentation sessions with biological and clinical focus include: Glycoproteomics in Biology and Medicine, Infectious Diseases, Immunity and the Microbiome, Cancer Early Detection and Prevention, Metabolism and Disease, Protein Proteoforms in Health and Disease, Aging and Neurological Diseases, and Posttranslational Regulation and Signaling. Additionally, sessions dedicated to technology developments include Multi-Omics, Proteome Organization in Space and Time, Advances in Technology, Structural/Chemical Proteomics, and Informatics: Emerging/ New Approaches. Poster sessions will offer a less formal format for presentation and discussion of scientific topics. Organized social activities will provide opportunities for further discussion and collaborative networking between attendees. A Business Meeting will provide an open forum to hear about the mission of US HUPO and give feedback. Attendance is expected to be 350-400, including 100- 150 students/postdocs. A special effort will be made to recruit minority and industrial participants, and also provide a venue for young investigators to present their work – through mechanisms such as “lightning” talks. Funding requested through this R13 mechanism will help support minority and young investigator participation in the conference. Short courses and workshops will also be offered to either train attendees in advanced proteomic technologies or provide a forum for discussing career options and other timely scientific topics.