A Kilohertz-Frequency, Continuous-Wave Transcranial Magnetic Stimulator to Increase the Dynamic Range of Subthreshold Neuromodulation

千赫兹频率连续波经颅磁刺激器可增加阈下神经调节的动态范围

• 批准号: 9896268
• 负责人: RICHARD IVRY
• 金额: $ 12.38万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9896268
• 关键词: Amplifiers; Basic Science; Biological Assay; Brain; Characteristics; Clinical; Communities; Custom; Data; Devices; Dose; Electric Stimulation; Electroencephalography; Electromagnetics; Engineering; Frequencies; Funding; Goals; Gold; Heating; Human; In Situ; Individual; Investigation; Liquid substance; Literature; Magnetism; Measurement; Measures; Mental disorders; Methods; Morphologic artifacts; Motor Cortex; Motor Evoked Potentials; Muscle; Nerve; Neurologic; Neuromodulator; Neuronal Plasticity; Neurons; Output; Participant; Peripheral; Physiologic pulse; Physiology; Population; Research; Research Personnel; Risk; Safety; Scalp structure; Series; Surface; System; Systems Analysis; Techniques; Testing; Tissues; Transcranial magnetic stimulation; Variant; Work; base; behavior influence; clinical application; cognitive enhancement; cognitive function; cognitive neuroscience; cranium; design and construction; electric field; expectation; experimental study; improved; interest; magnetic field; nervous system disorder; neuronal excitability; neuroregulation; post intervention; relating to nervous system; response; therapy design; tool; voltage

Project Summary/Abstract Non-invasive brain stimulation (NIBS) has attracted considerable interest in the cognitive neuroscience community, providing an important basic research tool to study brain function, with emerging clinical applications to enhance cognitive function in individuals with neurological disorders. Despite this potential, an emerging literature has highlighted concerns regarding the reliability and robustness of transcranial electric stimulation (tES), the primary NIBS method used to induce changes in brain plasticity through the application of subthreshold stimulation. These problems are likely related to the fact that tES systems can only induce modest electrical fields (E-field) at the cortical surface given that safety/tolerance issues limit the intensity of tES stimulation that can be delivered at the scalp. We propose to develop a radically new NIBS device, one in which we will apply oscillating magnetic fields at kHZ frequencies. Theoretical analyses indicate that this device will produce a significant increase in the range of E-field induction, as well as provide a number of other advantages, relative to current NIBS methods. The two-year funding period will be used to perform the theoretical analysis of the system, construct the device to deliver kHz magnetic stimulation, perform bench tests to confirm theoretical estimates, and conduct initial testing with human participants to assess the feasibility of the system for producing changes in cortical physiology. If our expectations are confirmed, this system will provide a powerful new tool for modulating neural excitability.

项目摘要/摘要 无创脑刺激在认知神经科学领域引起了极大的兴趣。 社区，为研究脑功能提供了重要的基础研究工具，并出现了临床应用 应用于增强神经性疾病患者的认知功能。尽管有这种潜力，但一个 新出现的文献强调了人们对经颅电信号的可靠性和健壮性的担忧 刺激(TES)，主要的NIBS方法，用于通过应用程序诱导大脑可塑性的变化 阈值下刺激的可能性。这些问题可能与这样一个事实有关，即TES系统只能 皮质表面的适度电场(E场)，因为安全/耐受性问题限制了 可在头皮传递的TES刺激。我们建议开发一种全新的NIBS设备，其中之一 我们将在KHZ频率上施加振荡磁场。理论分析表明，这 该装置将产生显著增加的电场感应范围，以及提供许多其他 相对于当前NIBS方法的优势。两年的资助期将用于执行 对系统进行了理论分析，搭建了提供khz磁刺激的装置，进行了台架试验 测试以确认理论估计，并与人类参与者进行初步测试以评估 大脑皮层生理学变化产生系统的可行性。如果我们的预期得到证实，这一点 该系统将为调节神经兴奋性提供一个强有力的新工具。