FLUOXETINE & DIVALPROEX IN IED

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 人类的攻击行为构成了对自己、他人或物体造成身体(或言语)伤害的行为。它可能是防御性的，可能是有预谋的，也可能是冲动的。防御性攻击性通常在人类行为的正常范围内。有预谋的和冲动的攻击行为被认为是病态的(Eichelman，1991)。表现出攻击性的倾向代表了一种行为特征。虽然攻击性行为的频率随着年龄的增长而减少，但研究表明，攻击性的特征始于生命早期，并持续到成年(Olweus 1979)。来自研究的数据始终将冲动的、但不是有预谋的攻击与生物(Coccaro 1998)、环境(Dodge等人，1994)以及药理(谢尔德等人，1976，Barratt等人，1997)或心理治疗反应联系起来。数据表明，反复的、有问题的、冲动的攻击(定义为间歇性爆炸性障碍/IED)影响着至少2.4%的美国人口。这种行为问题似乎很常见，可以通过药物和/或心理治疗干预进行治疗。 这项拟议的研究有一个主要目的，就是比较两种不同药物(氟西汀或双丙戊酸钠)与安慰剂在治疗间歇性爆炸障碍(IED)男性和女性冲动攻击行为方面的有效性。 受试者将是21-55岁的男性和女性，目前被诊断为间歇性爆炸性疾病。所有受试者都将接受诊断，然后试验三种治疗条件中的一种：(A)氟西汀12周疗程，(B)双丙戊酸钠12周疗程，或(C)安慰剂(糖丸)12周疗程。这项研究持续了16周。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human aggression constitutes an act that results in physical (or verbal) injury to self, others or objects. It may be defensive, premeditated or impulsive. Defensive aggression is generally seen within the normal range of human behavior. Premeditated and impulsive aggressive behaviors are viewed as pathological (Eichelman 1991). The tendency to behave aggressively represents a behavioral trait. While the frequency of aggressive acts tends to decrease with age, studies document the trait of aggressiveness begins early in life and continues through adulthood (Olweus 1979). Data from studies consistently link impulsive, but not premeditated, aggression to biological (Coccaro 1998), environmental (Dodge et al., 1994), and to pharmacological (Sheard et al, 1976, Barratt et al., 1997) or psychological treatment responses. Data suggest that recurrent, problematic, impulsive aggression (defined as Intermittent Explosive Disorder/IED) affects at least 2.4% of the US population. It appears that this behavioral problem is common and amenable to treatment by medication and/or psychological treatment interventions. The proposed study has one major aim, to compare the efficiency of two different medications (Fluoxetine or Divalproex Sodium) against placebo in the treatment of impulsive aggressive behavior by men and women with Intermittent Explosive Disorder (IED). Subjects will be men and women, 21-55 years old, with a current diagnosis of Intermittent Explosive Disorder. All subjects will undergo a diagnostic and then trialed to one of three treatment conditions: (a) 12-week course of Fluoxetine, (b) 12 week course of Divalproex Sodium, or (c) 12 week course of Placebo (sugar pill). The study lasts 16 weeks.