IMPULSIVE AGGRESSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的总体目标是在一个以人群为基础的双胞胎受试者样本(PennTwin：PI开发的队列)中，检验人类攻击性和冲动行为特征潜在的遗传和环境影响。在这项研究中，攻击性和冲动性将通过自我报告(生活史和个性问卷)和实验室的攻击性和冲动性测量来检验；5-羟色胺的测量将包括与5-羟色胺转运体相关的测量。在这个项目的第一阶段，将对双胞胎进行各种与冲动、攻击性和其他相关行为变量有关的问卷调查。在第二阶段，420对双胞胎(140个同性MZ，140个同性DZ，140个异性DZ，如果在第一阶段检测到遗传影响的性别差异，或者如果在第一阶段没有检测到基因影响的性别差异，则210个同性MZ和210个同性DZ)将在芝加哥大学临床神经科学研究室进行研究。数据将从各种实验程序中收集，包括对攻击性(点减攻击性范式：PSAP，泰勒攻击性范式：TAP，和自我攻击性范式：SAP)和冲动性(即时记忆任务：IMT，Go-Stop任务：GST，以及单一关键冲动性范式：Skip)、血小板5-羟色胺转运体结构(即，5-HTT结合位点的数量：Bmax)、功能(即，~3H-5-HT摄取速度：Vmax)、和基因(5-HTT启动子DNA多态性)，以确定5-羟色胺能功能的测量是否证明遗传性的证据，并检查遗传影响的性质，5-羟色胺与攻击性/冲动性之间的反向表型相关性之前已建立的20年前的研究。CRC资源的请求主要用于辅助服务，即获取血小板5-羟色胺转运体结合/摄取速度的血液样本和获得血小板5-羟色胺转运体结合/摄取速度的血液样本，以及获得用于DNA提取以确认合子状态和5-羟色胺转运体基因多态的血液样本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this study is to examine the gentic and environmental influences underlying the human behavioral traits of aggression and impulsivity in a population-based sample of twin subjects (PennTwins: a cohort developed by the PI). In this study, both aggression and impulsivity will be examined using self-report (life history and personality inventory) and laboratory measures of aggression and impulsivity; measures of 5-HT will include measures related to the 5-HT Transporter. In Phase I of this project, twins will be administered a variety of questionnaires realted to impulsivity and aggression and other related behavioral variables. In Phase II, 420 twin (140 same sexed MZ, 140 same sexed DZ, and 140 opposite sexed DZ if gender differences in genetic influences are detected in Phase I or 210 same sexed Mzand 210 same sexed DZ if no gender differences in genetic influence are detected in Phase I) pairs will be studied in our Clinical Neuroscience Research Unit at The University of Chicago. Data will be collected from various experimental procedures, including laboratory analog assessments of aggression (Point Subtraction Aggression Paradigm: PSAP, Taylor Aggression Paradign: TAP, and Self Aggression Paradigm: SAP) and impulsivity (Immediate Memory Task: IMT, Go-Stop Task: GST, and the Single Key Impulsivity Paradigm: SKIP) Platelet 5-HT Transporter structure (i.e., number of 5-HTT binding sites: Bmax), function (i.e., velocity of 3H-5-HT Uptake: Vmax), and genotype (5-HTT Promoeter DNA Polymorphism) will be obtained to determin whether measures of serotonergic function demonstrate evidence of heritability and to examine the nature of a genetice influence on the inverse phenotypic correlation between 5-HT and aggression/impulsivity previously established over two decades of previous research. CRC resources are requested primarily for ancillary services in obtaining blood samples for Platelet 5-HT Transporter Binding/Uptake Velocity and in obtaining blood samples for Platelet 5-HT Transporter Binding/Uptake Velocity and in obtaining blood samples for DNA Extraction for confirmation zygosity status and for genotyping of 5-HT Transporter polymorphisms.