MIND Diet Intervention to Prevent Alzheimer's Disease

MIND 饮食干预预防阿尔茨海默病

• 批准号: 9899178
• 负责人: Lisa L Barnes
• 金额: $ 535.64万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899178
• 关键词: Adult; Affect; Age; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease brain; Alzheimer' s disease risk; Alzheimer’s disease biomarker; American; Amyloid beta-42; Animals; Atrophic; Berry; Biochemical; Biochemical Markers; Biological; Biological Markers; Blood specimen; Body Weight decreased; Boston; Brain; Brain-Derived Neurotrophic Factor; Caloric Restriction; Cardiovascular system; Carotenoids; Chicago; Cholesterol; Chronic; Clinic; Clinical Trials; Cognition; Cognitive; Cost of Illness; Counseling; DASH diet; DNA analysis; Data; Dementia; Diabetes Mellitus; Diet; Dietary Component; Dietary Intervention; Dietary Practices; Disease; Dose; Epidemiology; Etiology; Family history of; Fishes; Folic Acid; Food; Food Patterns; Foundations; Future; Grapes; Hippocampus (Brain); Hospitals; Hybrids; Hypertension; Impaired cognition; Incidence; Individual; Inflammation; Intake; Internet; Intervention; Intervention Trial; Juice; Laboratories; Laboratory Study; Link; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mediator of activation protein; Medicine; Mediterranean Diet; Mental Depression; Mind; Modification; National Institute on Aging; Nerve Degeneration; Nutrient; Nutritional; Obesity; Omega-3 Fatty Acids; Outcome; Overweight; Oxidative Stress; Participant; Patients; Pharmacology; Phase; Physical activity; Plants; Plasma; Population; Prevalence; Prevention; Prevention strategy; Prevention trial; Public Health; Race; Randomized Controlled Trials; Reporting; Research Personnel; Rest; Risk Factors; Role; Source; Specific qualifier value; Structure; Testing; Tissues; Trust; Universities; Unsaturated Fats; Vegetables; Vitamins; Woman; age group; aged; alpha Tocopherol; apolipoprotein E-4; base; brain health; brain volume; cardiovascular risk factor; clinical practice; clinical research site; cognitive function; cognitive testing; cohort; cost; design; dietary guidelines; disorder prevention; gamma-Tocopherol; good diet; lifestyle intervention; metabolomics; multidisciplinary; neglect; neuroimaging; nutrition; pre-clinical; prevent; primary outcome; psychological distress; randomized trial; response; saturated fat; sex; side effect; trial design; web site

This R01 application, “MIND Diet Intervention to Prevent Alzheimer Disease,” is a Phase III randomized controlled trial designed to test the effects of a 3-year intervention of a hybrid of the Mediterranean and DASH diets, called MIND, on cognitive decline among 600 individuals 65+ years without cognitive impairment who are overweight and have suboptimal diets. The proposed MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) is a hybrid of the Mediterranean and DASH diets but with selected modifications based on the most compelling evidence in the diet-dementia field. The MIND diet has the same basic components of the DASH and Mediterranean diets, such as emphasis on natural plant-based foods and limited animal and high saturated fat foods, but uniquely specifies green leafy vegetables and berries as well as food component servings that reflect the nutrition-dementia evidence. There is a substantial body of evidence from epidemiological, animal and laboratory studies to link diet to brain health. Thus, the field is primed for the conduct of a large-scale prevention trial to establish a causal relation between diet and AD prevention. Establishing such a relation would greatly impact the public health and provide credibility to or refute numerous claims that various foods and dietary patterns are protective against AD. Dietary guidelines could be developed from the trial for use in clinical practice to inform patients about disease prevention. The proposed hybrid diet intervention has demonstrated effects on the prevention and treatment of most of the primary AD risk factors such as hypertension and diabetes, and the suppression of the two major underlying mechanisms of AD, oxidative stress and inflammation. The trial will employ a parallel group design comparing the effects on cognitive outcomes of the MIND intervention diet plus mild caloric restriction for weight loss to the control diet, usual diet with mild caloric restriction for weight loss. Biological effects of the MIND diet will be assessed by measurement of brain macro- and micro-structural integrity in 300 randomly selected participants. Other biochemical markers will be assessed in the entire cohort of 600 participants, including: plasma Abeta 42/Abeta 40, brain-derived neurotrophic factor (BDNF) and plasma markers of oxidative stress and inflammation. In addition, the trial will examine potential effect mediators and modifiers by a number of cardiovascular risk factors, AD biomarkers, and biological mechanisms. The proposed study has two clinical sites, one in Chicago (Rush University) and one in Boston (Harvard University), and centralized laboratories for data coordinating and analyses (Brigham & Women’s Hospital), neuroimaging analyses (Rush University), and specialized laboratories for tissue biochemical analyses.

这项R01应用名为“MIND饮食干预预防阿尔茨海默病”，是一项III期随机研究

项目成果

Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline.

• DOI: 10.1016/j.cct.2021.106270
• 发表时间: 2021-03
• 期刊: Contemporary clinical trials
• 影响因子: 2.2
• 作者: Liu X;Morris MC;Dhana K;Ventrelle J;Johnson K;Bishop L;Hollings CS;Boulin A;Laranjo N;Stubbs BJ;Reilly X;Carey VJ;Wang Y;Furtado JD;Marcovina SM;Tangney C;Aggarwal NT;Arfanakis K;Sacks FM;Barnes LL
• 通讯作者: Barnes LL

Vitamin D Intake and Brain Cortical Thickness in Community-Dwelling Overweight Older Adults: A Cross-Sectional Study.

• DOI: 10.1093/jn/nxab168
• 发表时间: 2021-06
• 期刊: The Journal of nutrition
• 作者: S. Lefèvre-Arbogast;K. Dhana;N. Aggarwal;Shengwei Zhang;Puja Agarwal;Xiaoran Liu;N. Laranjo;V. Carey;F. Sacks;L. Barnes;K. Arfanakis

Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants.

• DOI: 10.1017/jns.2021.56
• 发表时间: 2021
• 期刊: Journal of nutritional science
• 影响因子: 2.5
• 作者: Liu X;Dhana K;Furtado JD;Agarwal P;Aggarwal NT;Tangney C;Laranjo N;Carey V;Barnes LL;Sacks FM
• 通讯作者: Sacks FM

Properties of the Cognitive Function Battery for the MIND Diet Intervention to Prevent Alzheimer's Disease.

• DOI: 10.1017/s1355617721001089
• 发表时间: 2022-09
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Krueger KR;Dhana K;Aggarwal NT;Arfanakis K;Carey VJ;Sacks FM;Barnes LL
• 通讯作者: Barnes LL