MIND Diet Intervention to Prevent Alzheimer's Disease

MIND 饮食干预预防阿尔茨海默病

• 批准号: 9899178
• 负责人: Lisa L Barnes
• 金额: $ 535.64万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899178
• 关键词: Adult; Affect; Age; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease brain; Alzheimer' s disease risk; Alzheimer’s disease biomarker; American; Amyloid beta-42; Animals; Atrophic; Berry; Biochemical; Biochemical Markers; Biological; Biological Markers; Blood specimen; Body Weight decreased; Boston; Brain; Brain-Derived Neurotrophic Factor; Caloric Restriction; Cardiovascular system; Carotenoids; Chicago; Cholesterol; Chronic; Clinic; Clinical Trials; Cognition; Cognitive; Cost of Illness; Counseling; DASH diet; DNA analysis; Data; Dementia; Diabetes Mellitus; Diet; Dietary Component; Dietary Intervention; Dietary Practices; Disease; Dose; Epidemiology; Etiology; Family history of; Fishes; Folic Acid; Food; Food Patterns; Foundations; Future; Grapes; Hippocampus (Brain); Hospitals; Hybrids; Hypertension; Impaired cognition; Incidence; Individual; Inflammation; Intake; Internet; Intervention; Intervention Trial; Juice; Laboratories; Laboratory Study; Link; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mediator of activation protein; Medicine; Mediterranean Diet; Mental Depression; Mind; Modification; National Institute on Aging; Nerve Degeneration; Nutrient; Nutritional; Obesity; Omega-3 Fatty Acids; Outcome; Overweight; Oxidative Stress; Participant; Patients; Pharmacology; Phase; Physical activity; Plants; Plasma; Population; Prevalence; Prevention; Prevention strategy; Prevention trial; Public Health; Race; Randomized Controlled Trials; Reporting; Research Personnel; Rest; Risk Factors; Role; Source; Specific qualifier value; Structure; Testing; Tissues; Trust; Universities; Unsaturated Fats; Vegetables; Vitamins; Woman; age group; aged; alpha Tocopherol; apolipoprotein E-4; base; brain health; brain volume; cardiovascular risk factor; clinical practice; clinical research site; cognitive function; cognitive testing; cohort; cost; design; dietary guidelines; disorder prevention; gamma-Tocopherol; good diet; lifestyle intervention; metabolomics; multidisciplinary; neglect; neuroimaging; nutrition; pre-clinical; prevent; primary outcome; psychological distress; randomized trial; response; saturated fat; sex; side effect; trial design; web site

This R01 application, “MIND Diet Intervention to Prevent Alzheimer Disease,” is a Phase III randomized controlled trial designed to test the effects of a 3-year intervention of a hybrid of the Mediterranean and DASH diets, called MIND, on cognitive decline among 600 individuals 65+ years without cognitive impairment who are overweight and have suboptimal diets. The proposed MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) is a hybrid of the Mediterranean and DASH diets but with selected modifications based on the most compelling evidence in the diet-dementia field. The MIND diet has the same basic components of the DASH and Mediterranean diets, such as emphasis on natural plant-based foods and limited animal and high saturated fat foods, but uniquely specifies green leafy vegetables and berries as well as food component servings that reflect the nutrition-dementia evidence. There is a substantial body of evidence from epidemiological, animal and laboratory studies to link diet to brain health. Thus, the field is primed for the conduct of a large-scale prevention trial to establish a causal relation between diet and AD prevention. Establishing such a relation would greatly impact the public health and provide credibility to or refute numerous claims that various foods and dietary patterns are protective against AD. Dietary guidelines could be developed from the trial for use in clinical practice to inform patients about disease prevention. The proposed hybrid diet intervention has demonstrated effects on the prevention and treatment of most of the primary AD risk factors such as hypertension and diabetes, and the suppression of the two major underlying mechanisms of AD, oxidative stress and inflammation. The trial will employ a parallel group design comparing the effects on cognitive outcomes of the MIND intervention diet plus mild caloric restriction for weight loss to the control diet, usual diet with mild caloric restriction for weight loss. Biological effects of the MIND diet will be assessed by measurement of brain macro- and micro-structural integrity in 300 randomly selected participants. Other biochemical markers will be assessed in the entire cohort of 600 participants, including: plasma Abeta 42/Abeta 40, brain-derived neurotrophic factor (BDNF) and plasma markers of oxidative stress and inflammation. In addition, the trial will examine potential effect mediators and modifiers by a number of cardiovascular risk factors, AD biomarkers, and biological mechanisms. The proposed study has two clinical sites, one in Chicago (Rush University) and one in Boston (Harvard University), and centralized laboratories for data coordinating and analyses (Brigham & Women’s Hospital), neuroimaging analyses (Rush University), and specialized laboratories for tissue biochemical analyses.

这个R 01应用程序，“MIND饮食干预，以预防阿尔茨海默病，”是一个III期随机 一项对照试验，旨在测试地中海和DASH混合物的3年干预效果 饮食，称为MIND，对600名65岁以上无认知障碍的人的认知下降的影响， 超重和饮食不理想。建议的MIND饮食（Mediterranean-DASH干预， 神经退行性延迟）是地中海和DASH饮食的混合体，但有选择的修改 基于饮食痴呆领域最令人信服的证据。MIND饮食有相同的基本原理， DASH和地中海饮食的组成部分，例如强调天然植物性食物和有限的 动物和高饱和脂肪的食物，但独特地指定绿色多叶蔬菜和浆果以及食物 反映营养性痴呆证据的成分服务。有大量证据表明， 流行病学、动物和实验室研究将饮食与大脑健康联系起来。因此，该字段已准备好用于 进行大规模预防试验，以确定饮食和AD预防之间的因果关系。 建立这种关系将极大地影响公共卫生，并为许多人提供可信度或反驳他们的观点。 声称各种食物和饮食模式可以预防AD。饮食指南可能是 该试验是从临床实践中开发出来的，旨在为患者提供疾病预防信息。拟议 混合饮食干预已证明对大多数原发性AD的预防和治疗有效 高血压和糖尿病等危险因素，以及两种主要潜在机制的抑制 氧化应激和炎症。试验将采用平行组设计，比较 MIND干预饮食加轻度热量限制的认知结果与对照饮食相比， 日常饮食，轻度热量限制减肥。MIND饮食的生物学效应将通过以下方式进行评估： 对300名随机选择的参与者进行大脑宏观和微观结构完整性的测量。其他 将在600名参与者的整个队列中评估生化标志物，包括： 42/Abeta 40、脑源性神经营养因子（BDNF）和氧化应激的血浆标志物， 炎症此外，该试验将通过一些因素检查潜在的效应介质和修饰剂， 心血管危险因素、AD生物标志物和生物学机制。这项研究有两个临床 一个在芝加哥（拉什大学），一个在波士顿（哈佛大学）， 数据协调和分析（布里格姆妇女医院），神经影像分析（拉什大学），以及 组织生化分析的专业实验室。

项目成果

Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline.

• DOI: 10.1016/j.cct.2021.106270
• 发表时间: 2021-03
• 期刊: Contemporary clinical trials
• 影响因子: 2.2
• 作者: Liu X;Morris MC;Dhana K;Ventrelle J;Johnson K;Bishop L;Hollings CS;Boulin A;Laranjo N;Stubbs BJ;Reilly X;Carey VJ;Wang Y;Furtado JD;Marcovina SM;Tangney C;Aggarwal NT;Arfanakis K;Sacks FM;Barnes LL
• 通讯作者: Barnes LL

Vitamin D Intake and Brain Cortical Thickness in Community-Dwelling Overweight Older Adults: A Cross-Sectional Study.

• DOI: 10.1093/jn/nxab168
• 发表时间: 2021-06
• 期刊: The Journal of nutrition
• 作者: S. Lefèvre-Arbogast;K. Dhana;N. Aggarwal;Shengwei Zhang;Puja Agarwal;Xiaoran Liu;N. Laranjo;V. Carey;F. Sacks;L. Barnes;K. Arfanakis

Properties of the Cognitive Function Battery for the MIND Diet Intervention to Prevent Alzheimer's Disease.

• DOI: 10.1017/s1355617721001089
• 发表时间: 2022-09
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Krueger KR;Dhana K;Aggarwal NT;Arfanakis K;Carey VJ;Sacks FM;Barnes LL
• 通讯作者: Barnes LL

Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants.

• DOI: 10.1017/jns.2021.56
• 发表时间: 2021
• 期刊: Journal of nutritional science
• 影响因子: 2.5
• 作者: Liu X;Dhana K;Furtado JD;Agarwal P;Aggarwal NT;Tangney C;Laranjo N;Carey V;Barnes LL;Sacks FM
• 通讯作者: Sacks FM