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Core B: Clinical Core

核心 B：临床核心

基本信息

批准号：
10472765
负责人：
Lisa L Barnes
金额：
$ 38.03万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10472765
关键词：
Address African American Aging Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Autopsy Awareness Biochemical Biological Black Populations Blood Brain Cessation of life Clinical Clinical Data Clinical Research Collaborations Communities County DNA Data Data Collection Dementia Diagnosis Disease model Education Elderly Enrollment Ensure Epidemiology Etiology Funding Genomics Goals Health Disparities Research Health Sciences Heterogeneity Impaired cognition Latino Link Magnetic Resonance Imaging Memory Mentorship Methods Minority Molecular Molecular Profiling Nature Normalcy Online Systems Participant Pathogenesis Pathway interactions Population Process Proteomics Recommendation Recording of previous events Reporting Research Research Personnel Research Project Grants Resources Risk Factors Science Source Specimen Strategic Planning Structure Time Training Underrepresented Populations Woman brain magnetic resonance imaging brain tissue cohort data hub data management data sharing design diverse data epigenomics ethnic diversity experience health disparity health equity high risk human data improved in vivo knowledge base men metabolomics motor impairment multidisciplinary neuroimaging neuroimaging marker neuropathology open data outreach personalized approach predictive modeling programs public-private partnership racial diversity recruit religious order study research clinical testing research study response success tool underserved community virtual

项目摘要

ABSTRACT – CLINICAL CORE The overall goal of the Clinical Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease-related dementias (ADRD) by providing data and biospecimens from well-characterized, longitudinally-followed older Blacks who initially enroll without dementia from the community. Blacks are at greater risk of ADRD, but the field has struggled to engage this population in clinical research, particularly in studies that involve biofluids and brain tissue for molecular and biochemical profiling. The Clinical Core has demonstrated expertise and success in conducting studies with older persons under-represented in aging research. It provides participants, clinical data, and biospecimens (brain tissue, DNA, and blood) to support a wide variety of studies by investigators at Rush and across the county, particularly those that historically have had limited data from diverse groups (e.g., neuroimaging, genomics, epigenomics, proteomics, and metabolomics). The Core will 1) continue to recruit, enroll, and perform annual clinical evaluations that are harmonized with the Religious Orders Study and Latino Cores, and two ADRC-affiliated studies, the Rush Memory and Aging Project (MAP) and the Minority Aging Research Study (MARS), 2) increase awareness of the importance of brain donation through culturally-tailored educational programs, and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA Strategic plan. This Core, together with the harmonized cohorts at the Rush Alzheimer’s Disease Center, represents one of the largest sources of brain tissue from older Blacks initially without dementia in the U.S. By focusing on older Blacks, a population at high risk for ADRD, to provide clinical data, brain tissue, and DNA, the Clinical Core will continue to serve as a vital resource to the wider aging and Alzheimer’s research community for advancing the science of health disparities and health equity.

摘要-临床核心