MRI markers of brain aging and risk factors for cognitive decline in older African Americans

老年非裔美国人大脑衰老的 MRI 标记和认知能力下降的危险因素

基本信息

批准号：
10408780
负责人：
Lisa L Barnes
金额：
$ 68.82万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10408780
关键词：
Address Affect African American population Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Blood Vessels Brain Brain region Cognition Cognitive aging Communities Data Disease Disparity Emotional Exhibits Future Goals Health Impaired cognition Infrastructure Intervention Studies Knowledge Link Literature MRI Scans Magnetic Resonance Imaging Measures Memory Minority Neurobiology Not Hispanic or Latino Occupational Outcome Pathway interactions Prevention Public Health Research Risk Risk Factors Speed Testing Time aging brain brain magnetic resonance imaging brain volume cognitive function cost disorder risk early life adversity high risk indexing magnetic resonance imaging biomarker middle age mild cognitive impairment multimodal neuroimaging neurobiological mechanism neuroimaging novel perceived discrimination psychosocial public health relevance racial difference research study social

项目摘要

ABSTRACT The aging research community has identified numerous risk factors associated with the full spectrum of cognition including mild cognitive impairment and Alzheimer’s disease (AD), and there is greater understanding of the underlying brain mechanisms. Unfortunately, the vast majority of knowledge comes from studies of primarily non-Hispanic Whites. Although African Americans bear a disproportionate burden of Alzheimer’s disease (AD) and cognitive impairment, the neurobiologic mechanisms underlying these disparities remain elusive. The overall goal of the proposed study is to investigate the underlying neurobiologic mechanisms linking culturally-relevant psychosocial risk factors to cognitive decline and risk of AD in older African Americans. Existing literature with MRI data in older African Americans has focused almost exclusively on cross-sectional associations of cognition or incident AD, and has examined traditional risk factors. Very few studies of African Americans have examined culturally relevant risk factors with repeated measures of cognitive function and brain integrity over time to test the underlying neurobiologic mechanisms linking risk factors to cognitive decline and risk of AD. We propose to interrogate changes in structural and functional integrity on MRI as key neurobiologic substrates linking these socially relevant risk factors to cognitive decline and risk of AD in African Americans. Leveraging the well-established infrastructure of the Minority Aging Research Study (MARS), including available data on risk factors, and repeated measures of cognitive function, we will use a multi-modal neuroimaging approach to acquire antemortem MRI scans on 400 African Americans and quantify change in a number of brain MRI indices to address the Specific Aims. Aim 1 will examine the relation of change in brain MRI indices with rate of cognitive decline and risk of AD among older African Americans; Aim 2 will examine the relation of early and mid-life cultural risk factors with change in structural and functional brain MRI indices among older African Americans; Aim 3 will determine if change in brain MRI indices affects the relation of early- and mid-life risk factors to rate of decline and risk of AD among older African Americans; and taking advantage of neuroimaging and cognitive function data available at no cost from the Rush Memory and Aging Project (MAP), Aim 4 will identify racial differences in the relation of change in MRI structural and functional brain integrity to cognitive decline. Cognitive impairment associated with aging is a large and growing public health problem that disproportionately burdens African Americans. Knowledge of the neurobiologic pathways linking risk factors to cognitive decline will ultimately provide targets for future prevention/intervention studies, and will have a strong and sustained impact on the field.

抽象的老龄化研究界已经确定了与全部范围相关的许多风险因素认知包括轻度认知障碍和阿尔茨海默氏病（AD），并且有更多的了解基本的大脑机制。不幸的是，绝大多数知识来自于研究尽管非洲裔美国人对阿尔茨海默氏症的燃烧不成比例疾病（AD）和认知障碍，这些分布的神经生物学机制仍然存在难以捉摸。拟议的研究的总体目标是研究潜在的神经生物学将与文化相关的社会心理风险因素与认知下降和AD风险联系起来的机制年长的非裔美国人。现有的文献带有非裔美国人的MRI数据几乎关注专门介绍认知或事件广告的横断面关联，并检查了传统风险因素。很少有对非洲裔美国人的研究检查与文化相关的风险因素随着时间的流逝，认知功能和大脑完整性的度量，以测试潜在的神经生物学机制将危险因素与认知下降和AD风险联系起来。我们建议询问结构和 MRI的功能完整性是将这些与社会相关的风险因素联系起来的关键神经生物学基质非裔美国人的认知能力下降和AD风险。利用公认的基础设施少数族裔老化研究（MARS），包括有关风险因素的可用数据，以及重复的措施认知功能，我们将使用多模式神经影像学方法在400 非洲裔美国人并量化许多大脑MRI指数的变化，以解决具体目标。目标1 将研究大脑MRI指数的变化与认知能力下降和AD风险的关系年长的非裔美国人； AIM 2将研究早期和中年文化风险因素与变化的关系年长的非裔美国人的结构和功能性脑部MRI指数； AIM 3将确定是否发生变化大脑MRI指数影响早期和中期危险因素与衰落率和AD风险的关系年长的非裔美国人；并利用否时可用的神经影像学和认知功能数据 RUSH记忆和老化项目（MAP）的成本，AIM 4将确定在关系中的种族差异 MRI结构和功能性脑完整性的变化随着认知能力下降。认知障碍相关随着衰老而是一个越来越多的公共卫生问题，对伯恩斯非裔美国人的比例不成比例。了解将风险因素与认知下降联系起来的神经生物学途径最终将提供目标为了将来预防/干预研究，并将对该领域产生强大的持续影响。