Core B: Clinical Core

核心 B：临床核心

• 批准号: 10669636
• 负责人: Lisa L Barnes
• 金额: $ 38.03万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669636
• 关键词: Acceleration; Address; African American; Aging; Agreement; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Autopsy; Awareness; Biochemical; Biological; Biological Markers; Black Populations; Blood; Brain; Cessation of life; Clinical; Clinical Data; Clinical Research; Collaborations; Communities; County; DNA; Data; Data Collection; Dementia; Diagnosis; Disease model; Disparity; Education; Elderly; Enrollment; Ensure; Epidemiology; Etiology; Funding; Genomics; Goals; Health Disparities Research; Heterogeneity; Impaired cognition; Latino; Link; Magnetic Resonance Imaging; Memory; Mentorship; Methods; Minority; Molecular; Molecular Profiling; Nature; Normalcy; Online Systems; Participant; Pathogenesis; Pathway interactions; Population; Process; Productivity; Proteomics; Recommendation; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Science; Source; Specimen; Strategic Planning; Structure; Time; Training; Underrepresented Populations; Woman; brain magnetic resonance imaging; brain tissue; cohort; data hub; data management; data sharing; design; diverse data; epigenomics; ethnic diversity; experience; health disparity; health equity; high risk; human data; improved; in vivo; knowledge base; men; metabolomics; motor impairment; multidisciplinary; neuroimaging; neuropathology; open data; outreach; personalized approach; predictive modeling; programs; public-private partnership; racial diversity; recruit; religious order study; research clinical testing; research study; response; success; tool; underserved community; virtual

ABSTRACT – CLINICAL CORE The overall goal of the Clinical Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease-related dementias (ADRD) by providing data and biospecimens from well-characterized, longitudinally-followed older Blacks who initially enroll without dementia from the community. Blacks are at greater risk of ADRD, but the field has struggled to engage this population in clinical research, particularly in studies that involve biofluids and brain tissue for molecular and biochemical profiling. The Clinical Core has demonstrated expertise and success in conducting studies with older persons under-represented in aging research. It provides participants, clinical data, and biospecimens (brain tissue, DNA, and blood) to support a wide variety of studies by investigators at Rush and across the county, particularly those that historically have had limited data from diverse groups (e.g., neuroimaging, genomics, epigenomics, proteomics, and metabolomics). The Core will 1) continue to recruit, enroll, and perform annual clinical evaluations that are harmonized with the Religious Orders Study and Latino Cores, and two ADRC-affiliated studies, the Rush Memory and Aging Project (MAP) and the Minority Aging Research Study (MARS), 2) increase awareness of the importance of brain donation through culturally-tailored educational programs, and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA Strategic plan. This Core, together with the harmonized cohorts at the Rush Alzheimer’s Disease Center, represents one of the largest sources of brain tissue from older Blacks initially without dementia in the U.S. By focusing on older Blacks, a population at high risk for ADRD, to provide clinical data, brain tissue, and DNA, the Clinical Core will continue to serve as a vital resource to the wider aging and Alzheimer’s research community for advancing the science of health disparities and health equity.

摘要——临床核心 临床核心的总体目标是支持高质量、前沿的病因学研究项目， 阿尔茨海默病相关痴呆 (ADRD) 的发病机制、诊断、治疗和预防 提供来自特征明确、纵向跟踪的老年黑人的数据和生物样本，这些黑人最初 没有痴呆症的人可以从社区报名。黑人患 ADRD 的风险更大，但该领域一直在努力 让这一人群参与临床研究，特别是涉及生物体液和脑组织的研究 分子和生化分析。临床核心在进行 在老龄化研究中，针对老年人的研究代表性不足。它提供参与者、临床数据和 生物样本（脑组织、DNA 和血液）支持 Rush 和 Rush 的研究人员进行的各种研究 整个县，特别是那些历史上来自不同群体的数据有限的县（例如， 神经影像学、基因组学、表观基因组学、蛋白质组学和代谢组学）。核心将 1) 继续招募， 注册并进行与宗教团体研究和拉丁裔协调一致的年度临床评估 核心以及两项 ADRC 附属研究：Rush Memory and Aging Project (MAP) 和 Minority Aging 研究 (MARS)，2) 通过文化定制提高对大脑捐赠重要性的认识 教育计划，以及 3) 促进符合外部资助的研究 2017 年 NIA 战略计划。该核心与 Rush 阿尔茨海默病中心的协调团队一起 中心，代表了最初没有痴呆症的老年黑人脑组织的最大来源之一 美国通过关注老年黑人这一 ADRD 高危人群，提供临床数据、脑组织和 DNA，临床核心将继续作为更广泛的老龄化和阿尔茨海默病研究的重要资源 社区致力于推进健康差异和健康公平的科学。