Core B: Clinical Core

核心 B：临床核心

基本信息

批准号：
10669636
负责人：
Lisa L Barnes
金额：
$ 38.03万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10669636
关键词：
Acceleration Address African American Aging Agreement Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Autopsy Awareness Biochemical Biological Biological Markers Black Populations Blood Brain Cessation of life Clinical Clinical Data Clinical Research Collaborations Communities County DNA Data Data Collection Dementia Diagnosis Disease model Disparity Education Elderly Enrollment Ensure Epidemiology Etiology Funding Genomics Goals Health Disparities Research Heterogeneity Impaired cognition Latino Link Magnetic Resonance Imaging Memory Mentorship Methods Minority Molecular Molecular Profiling Nature Normalcy Online Systems Participant Pathogenesis Pathway interactions Population Process Productivity Proteomics Recommendation Recording of previous events Reporting Research Research Personnel Research Project Grants Resources Risk Factors Science Source Specimen Strategic Planning Structure Time Training Underrepresented Populations Woman brain magnetic resonance imaging brain tissue cohort data hub data management data sharing design diverse data epigenomics ethnic diversity experience health disparity health equity high risk human data improved in vivo knowledge base men metabolomics motor impairment multidisciplinary neuroimaging neuropathology open data outreach personalized approach predictive modeling programs public-private partnership racial diversity recruit religious order study research clinical testing research study response success tool underserved community virtual

项目摘要

ABSTRACT – CLINICAL CORE The overall goal of the Clinical Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease-related dementias (ADRD) by providing data and biospecimens from well-characterized, longitudinally-followed older Blacks who initially enroll without dementia from the community. Blacks are at greater risk of ADRD, but the field has struggled to engage this population in clinical research, particularly in studies that involve biofluids and brain tissue for molecular and biochemical profiling. The Clinical Core has demonstrated expertise and success in conducting studies with older persons under-represented in aging research. It provides participants, clinical data, and biospecimens (brain tissue, DNA, and blood) to support a wide variety of studies by investigators at Rush and across the county, particularly those that historically have had limited data from diverse groups (e.g., neuroimaging, genomics, epigenomics, proteomics, and metabolomics). The Core will 1) continue to recruit, enroll, and perform annual clinical evaluations that are harmonized with the Religious Orders Study and Latino Cores, and two ADRC-affiliated studies, the Rush Memory and Aging Project (MAP) and the Minority Aging Research Study (MARS), 2) increase awareness of the importance of brain donation through culturally-tailored educational programs, and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA Strategic plan. This Core, together with the harmonized cohorts at the Rush Alzheimer’s Disease Center, represents one of the largest sources of brain tissue from older Blacks initially without dementia in the U.S. By focusing on older Blacks, a population at high risk for ADRD, to provide clinical data, brain tissue, and DNA, the Clinical Core will continue to serve as a vital resource to the wider aging and Alzheimer’s research community for advancing the science of health disparities and health equity.

摘要 - 临床核心临床核心的总体目标是支持高质量，尖端，病因研究项目，通过发病机理，诊断，治疗和预防阿尔茨海默氏病与疾病相关的痴呆症（ADRD）从最初的纵向，纵向关注的老年黑人提供数据和生物测量没有社区的痴呆症注册。黑人面临着更大的ADRD风险，但是该领域一直在努力使这一人群参与临床研究，特别是在涉及生物流体和脑组织的研究中分子和生化分析。临床核心表现出专业知识和成功的成功与老年人相关的老年人研究的研究。它提供参与者，临床数据和生物测量（脑组织，DNA和血液）支持Rush和Rush和在全县神经影像学，基因组学，表观基因组学，蛋白质组学和代谢组学）。核心将继续招募，注册并进行年度临床评估，这些评估与宗教秩序研究和拉丁裔进行协调核心以及两项与ADRC相关的研究，Rush Memory and Ening Project（MAP）和少数族裔老化研究研究（火星），2）提高人们对大脑捐赠的重要性的认识教育计划，以及3）促进基于外部资助的研究，该研究与 2017年NIA战略计划。这个核心，以及在阿尔茨海默氏病的统一队列中心代表了老年黑人最大的脑组织的来源之一，最初是没有痴呆症的。美国通过专注于老年黑人，ADRD高风险的人口，提供临床数据，脑组织和 DNA，临床核心将继续成为更广泛的衰老和阿尔茨海默氏症研究的重要资源促进健康差异和健康平等科学的社区。