Core B: Clinical Core

核心 B：临床核心

• 批准号: 10264495
• 负责人: Lisa L Barnes
• 金额: $ 38.03万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264495
• 关键词: Address; African American; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Autopsy; Awareness; Biochemical; Biological; Blood; Brain; Cessation of life; Clinical; Clinical Data; Clinical Research; Collaborations; Communities; County; DNA; Data; Data Collection; Dementia; Diagnosis; Disease model; Education; Elderly; Enrollment; Ensure; Epidemiology; Etiology; Funding; Genomics; Goals; Health Sciences; Heterogeneity; Impaired cognition; Latino; Link; Magnetic Resonance Imaging; Memory; Mentorship; Methods; Minority; Molecular; Molecular Profiling; Nature; Normalcy; Online Systems; Participant; Pathogenesis; Pathway interactions; Population; Process; Proteomics; Recommendation; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Science; Source; Specimen; Strategic Planning; Structure; Time; Training; Woman; brain tissue; cohort; data hub; data management; data sharing; design; diverse data; epigenomics; ethnic diversity; experience; health disparity; health equity; high risk; human data; improved; in vivo; knowledge base; men; metabolomics; motor impairment; multidisciplinary; neuroimaging; neuroimaging marker; neuropathology; open data; outreach; personalized approach; predictive modeling; programs; public-private partnership; racial diversity; recruit; religious order study; research clinical testing; research study; response; success; tool; underserved community; virtual

ABSTRACT – CLINICAL CORE The overall goal of the Clinical Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease-related dementias (ADRD) by providing data and biospecimens from well-characterized, longitudinally-followed older Blacks who initially enroll without dementia from the community. Blacks are at greater risk of ADRD, but the field has struggled to engage this population in clinical research, particularly in studies that involve biofluids and brain tissue for molecular and biochemical profiling. The Clinical Core has demonstrated expertise and success in conducting studies with older persons under-represented in aging research. It provides participants, clinical data, and biospecimens (brain tissue, DNA, and blood) to support a wide variety of studies by investigators at Rush and across the county, particularly those that historically have had limited data from diverse groups (e.g., neuroimaging, genomics, epigenomics, proteomics, and metabolomics). The Core will 1) continue to recruit, enroll, and perform annual clinical evaluations that are harmonized with the Religious Orders Study and Latino Cores, and two ADRC-affiliated studies, the Rush Memory and Aging Project (MAP) and the Minority Aging Research Study (MARS), 2) increase awareness of the importance of brain donation through culturally-tailored educational programs, and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA Strategic plan. This Core, together with the harmonized cohorts at the Rush Alzheimer’s Disease Center, represents one of the largest sources of brain tissue from older Blacks initially without dementia in the U.S. By focusing on older Blacks, a population at high risk for ADRD, to provide clinical data, brain tissue, and DNA, the Clinical Core will continue to serve as a vital resource to the wider aging and Alzheimer’s research community for advancing the science of health disparities and health equity.

摘要--临床核心 临床核心的总体目标是支持高质量、尖端的病因学研究项目， 阿尔茨海默病相关痴呆(ADRD)的发病机制、诊断、治疗和预防 提供来自特征良好、纵向跟踪的老年黑人的数据和生物标本，这些黑人最初 从社区注册，而不是痴呆症。黑人患ADRD的风险更大，但这一领域一直在努力 让这些人参与临床研究，特别是涉及生物体液和脑组织的研究 分子和生化分析。临床核心已经证明了专业知识和成功地进行 关于老年人的研究在老龄化研究中的代表性不足。它提供参与者、临床数据和 生物样品(脑组织、DNA和血液)，以支持Rush和 在整个县，特别是那些历史上来自不同群体的数据有限的国家(例如， 神经成像、基因组学、表观基因组学、蛋白质组学和代谢组学)。核心将1)继续招聘， 注册，并执行与宗教修道会研究和拉丁裔协调一致的年度临床评估 以及ADRC附属的两项研究，即快速记忆和老龄化项目(MAP)和少数民族老龄化 研究研究(MARS)，2)通过文化定制提高对脑捐赠重要性的认识 教育方案，以及3)促进外部资助的研究，以符合 2017年NIA战略计划。这一核心，以及拉什阿尔茨海默氏症的协调队列 该中心代表了来自老年黑人的最大脑组织来源之一，最初在 美国通过关注老年黑人，这是ADRD的高危人群，提供临床数据、脑组织和 DNA，临床核心将继续作为更广泛的老龄化和阿尔茨海默氏症研究的重要资源 促进健康差距和健康公平的科学。