Core B: Clinical Core

核心 B：临床核心

• 批准号: 10264495
• 负责人: Lisa L Barnes
• 金额: $ 38.03万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264495
• 关键词: Address; African American; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Autopsy; Awareness; Biochemical; Biological; Blood; Brain; Cessation of life; Clinical; Clinical Data; Clinical Research; Collaborations; Communities; County; DNA; Data; Data Collection; Dementia; Diagnosis; Disease model; Education; Elderly; Enrollment; Ensure; Epidemiology; Etiology; Funding; Genomics; Goals; Health Sciences; Heterogeneity; Impaired cognition; Latino; Link; Magnetic Resonance Imaging; Memory; Mentorship; Methods; Minority; Molecular; Molecular Profiling; Nature; Normalcy; Online Systems; Participant; Pathogenesis; Pathway interactions; Population; Process; Proteomics; Recommendation; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk Factors; Science; Source; Specimen; Strategic Planning; Structure; Time; Training; Woman; brain tissue; cohort; data hub; data management; data sharing; design; diverse data; epigenomics; ethnic diversity; experience; health disparity; health equity; high risk; human data; improved; in vivo; knowledge base; men; metabolomics; motor impairment; multidisciplinary; neuroimaging; neuroimaging marker; neuropathology; open data; outreach; personalized approach; predictive modeling; programs; public-private partnership; racial diversity; recruit; religious order study; research clinical testing; research study; response; success; tool; underserved community; virtual

ABSTRACT – CLINICAL CORE The overall goal of the Clinical Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease-related dementias (ADRD) by providing data and biospecimens from well-characterized, longitudinally-followed older Blacks who initially enroll without dementia from the community. Blacks are at greater risk of ADRD, but the field has struggled to engage this population in clinical research, particularly in studies that involve biofluids and brain tissue for molecular and biochemical profiling. The Clinical Core has demonstrated expertise and success in conducting studies with older persons under-represented in aging research. It provides participants, clinical data, and biospecimens (brain tissue, DNA, and blood) to support a wide variety of studies by investigators at Rush and across the county, particularly those that historically have had limited data from diverse groups (e.g., neuroimaging, genomics, epigenomics, proteomics, and metabolomics). The Core will 1) continue to recruit, enroll, and perform annual clinical evaluations that are harmonized with the Religious Orders Study and Latino Cores, and two ADRC-affiliated studies, the Rush Memory and Aging Project (MAP) and the Minority Aging Research Study (MARS), 2) increase awareness of the importance of brain donation through culturally-tailored educational programs, and 3) facilitate externally funded research that aligns with the recommendations of the 2017 NIA Strategic plan. This Core, together with the harmonized cohorts at the Rush Alzheimer’s Disease Center, represents one of the largest sources of brain tissue from older Blacks initially without dementia in the U.S. By focusing on older Blacks, a population at high risk for ADRD, to provide clinical data, brain tissue, and DNA, the Clinical Core will continue to serve as a vital resource to the wider aging and Alzheimer’s research community for advancing the science of health disparities and health equity.

摘要-临床核心 临床核心的总体目标是支持高质量的，尖端的，病因学研究项目， 阿尔茨海默病相关性痴呆（ADRD）的发病机制、诊断、治疗和预防 提供数据和生物标本，从良好的特点，跟踪老年黑人谁最初 没有痴呆症的人从社区登记。黑人患ADRD的风险更大，但该领域一直在努力 让这一人群参与临床研究，特别是涉及生物液体和脑组织的研究， 分子和生化分析。临床核心已经证明了专业知识和成功地进行 老年人在老龄化研究中的代表性不足。它提供参与者，临床数据， 生物标本（脑组织、DNA和血液），以支持拉什大学研究人员的各种研究， 全国各地，特别是那些历史上有来自不同群体的有限数据的人（例如， 神经成像、基因组学、表观基因组学、蛋白质组学和代谢组学）。核心将1）继续招募， 注册，并进行年度临床评价，与宗教秩序研究和拉丁美洲协调一致 核心，以及两个ADRC附属研究，拉什记忆和老龄化项目（MAP）和少数老龄化 研究研究（MARS），2）通过文化定制，提高对大脑捐赠重要性的认识 教育计划，以及3）促进外部资助的研究，符合建议的 2017年NIA战略计划。这个核心，连同拉什阿尔茨海默氏症的和谐队列， 中心，代表了最大的脑组织来源之一，来自老年黑人最初没有痴呆症， 美国通过关注老年黑人，ADRD的高风险人群，提供临床数据，脑组织， DNA，临床核心将继续作为一个重要的资源，以更广泛的老龄化和阿尔茨海默氏症的研究 促进健康差距和健康公平的科学。