Molecular and Structural Biology (MSB)

分子与结构生物学（MSB）

基本信息

批准号：
9750197
负责人：
DAVID S WEBER
金额：
$ 3.5万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9750197
关键词：
Address Basic Science Biochemistry Bioinformatics Biomedical Engineering Biophysics Cancer Biology Cancer Center Cancer Center Support Grant Catchment Area Cell physiology Cellular biology Clinical Trials Collaborations Cultural Backgrounds DNA Repair Defect Development Faculty Funding Funding Agency Gene Expression Genetic Transcription Genomic Instability Genomics Goals Grant Institutes Institution Lead Malignant Neoplasms Malignant neoplasm of prostate Maryland Molecular Molecular Biology Oncogenic Pathway interactions Peer Review Process Proteomics Publications Publishing Regulation Research Research Personnel Schools Scientist Signal Pathway Signal Transduction Source Students Testing Training Training and Education Translating Translational Research Translations Tumor Suppressor Genes Tumor Suppressor Proteins United States National Institutes of Health Universities anti-cancer anticancer research cancer cell carcinogenesis clinical application design faculty support leukemia/lymphoma malignant breast neoplasm melanoma member novel strategies programs protein expression structural biology

项目摘要

15.0 Abstract: Molecular and Structural Biology Program The overarching goals of the Molecular and Structural Biology (MSB) Program of UMGCC are to elucidate molecular mechanisms and cellular processes that are altered in cancer and to encourage translation of these basic scientific findings toward the development of novel strategies for treating cancer. To achieve these goals, the program focuses on three themes: Theme 1: DNA repair and checkpoint signaling—characterizing defects in DNA repair and checkpoint signaling and understanding how these defects impact cancer development; Theme 2: Inappropriate gene expression—determining how defects in transcriptional and posttranscriptional processes lead to inappropriate regulation of protein expression in cancer; and Theme 3: Oncogenes and tumor suppressors—delineating how signaling pathways (i.e., oncogenic, tumor suppressor, etc.) are deregulated in cancer and identifying specific biomolecules that can be targeted to reverse these effects. The MSB Program has 50 members representing 16 academic departments and 6 schools of the University of Maryland. Members of the program conduct cancer-focused research that receives $6.78 million total annual funding, including $2.34 million from NCI and $3.58 million from other peer-reviewed sources. In addition, the MSB Program members receive over $0.86 million annually from non-peer-reviewed funding sources. Between January 2010 and December 2014, MSB members authored 664 cancer-related publications, of which 13 percent resulted from intraprogrammatic and 18 percent from interprogrammatic collaborations. Approximately 48 percent of the publications represent collaborations with external investigators. Research efforts by MSB faculty are supported by extensive use of the SBSS, FCSS, TLSS, PBSS, ISS, and BSS.

15.0摘要：分子和结构生物学计划 UMGCC的分子和结构生物学（MSB）计划的总体目标是阐明分子机制和细胞过程在癌症中改变并鼓励这些转化基本的科学发现，发展了治疗癌症的新型策略。为了实现这些目标，该计划侧重于三个主题：主题1：DNA维修和检查点信号 - 特征 DNA修复和检查点信号传导的缺陷，并了解这些缺陷如何影响癌症发展;主题2：不适当的基因表达 - 确定转录和转录中的缺陷如何转录后过程导致癌症中蛋白质表达的不当调节。和主题3：癌基因和肿瘤补充剂 - 限制信号通路（即致癌，肿瘤）抑制剂等）在癌症中放松管制，并确定可以针对的特定生物分子扭转这些影响。 MSB计划有50名成员，代表16个学术系和6所大学的学校马里兰州。该计划的成员进行以癌症为中心的研究，该研究将获得678万美元资金，包括来自NCI的234万美元，来自其他同行评审来源的358万美元。另外， MSB计划成员每年从未经审查的资金来源获得超过860万美元的收入。之间 2010年1月和2014年12月，MSB成员撰写了664个与癌症相关的出版物，其中13个百分比是由磁内图造成的，而构造媒介合作的百分比为18％。大约 48％的出版物代表与外部研究人员的合作。 MSB的研究工作广泛使用SBSS，FCSS，TLSS，PBSS，ISS和BSS的教师支持。