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Molecular and Structural Biology (MSB)

分子与结构生物学（MSB）

基本信息

批准号：
9750197
负责人：
DAVID S WEBER
金额：
$ 3.5万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9750197
关键词：
Address Basic Science Biochemistry Bioinformatics Biomedical Engineering Biophysics Cancer Biology Cancer Center Cancer Center Support Grant Catchment Area Cell physiology Cellular biology Clinical Trials Collaborations Cultural Backgrounds DNA Repair Defect Development Faculty Funding Funding Agency Gene Expression Genetic Transcription Genomic Instability Genomics Goals Grant Institutes Institution Lead Malignant Neoplasms Malignant neoplasm of prostate Maryland Molecular Molecular Biology Oncogenic Pathway interactions Peer Review Process Proteomics Publications Publishing Regulation Research Research Personnel Schools Scientist Signal Pathway Signal Transduction Source Students Testing Training Training and Education Translating Translational Research Translations Tumor Suppressor Genes Tumor Suppressor Proteins United States National Institutes of Health Universities anti-cancer anticancer research cancer cell carcinogenesis clinical application design faculty support leukemia/lymphoma malignant breast neoplasm melanoma member novel strategies programs protein expression structural biology

项目摘要

15.0 Abstract: Molecular and Structural Biology Program The overarching goals of the Molecular and Structural Biology (MSB) Program of UMGCC are to elucidate molecular mechanisms and cellular processes that are altered in cancer and to encourage translation of these basic scientific findings toward the development of novel strategies for treating cancer. To achieve these goals, the program focuses on three themes: Theme 1: DNA repair and checkpoint signaling—characterizing defects in DNA repair and checkpoint signaling and understanding how these defects impact cancer development; Theme 2: Inappropriate gene expression—determining how defects in transcriptional and posttranscriptional processes lead to inappropriate regulation of protein expression in cancer; and Theme 3: Oncogenes and tumor suppressors—delineating how signaling pathways (i.e., oncogenic, tumor suppressor, etc.) are deregulated in cancer and identifying specific biomolecules that can be targeted to reverse these effects. The MSB Program has 50 members representing 16 academic departments and 6 schools of the University of Maryland. Members of the program conduct cancer-focused research that receives $6.78 million total annual funding, including $2.34 million from NCI and $3.58 million from other peer-reviewed sources. In addition, the MSB Program members receive over $0.86 million annually from non-peer-reviewed funding sources. Between January 2010 and December 2014, MSB members authored 664 cancer-related publications, of which 13 percent resulted from intraprogrammatic and 18 percent from interprogrammatic collaborations. Approximately 48 percent of the publications represent collaborations with external investigators. Research efforts by MSB faculty are supported by extensive use of the SBSS, FCSS, TLSS, PBSS, ISS, and BSS.

15.0摘要：分子与结构生物学专业