Building skills in translation through hands-on experience in patient-inspired scientific inquiry

通过患者启发的科学探究的实践经验培养翻译技能

• 批准号: 9900282
• 负责人: Mark S Anderson
• 金额: $ 8.64万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9900282
• 关键词: Patients; Scientific Inquiry; Translations; experience; skills

PROJECT SUMMARY This is an application for an Administrative Supplement to the Medical Scientist Training Program (MSTP) T32 training grant award. The Need: The goal of the UCSF MSTP is to train the next generation of physician-investigators and equip them with the research and clinical skills they need “to harness new technologies to advance human health.” However, translation, the process of applying biological insights to clinical problems and vice versa, is difficult and requires unique skills that are not routinely taught in medical school or graduate school. Additional integrative approaches are needed to cultivate these important skills. The Project: We will develop an innovative program for physician-scientist trainees to build skills in “bedside to bench” and “bench to bedside” translation through hands-on experience in patient-inspired scientific inquiry. Trainees will work closely with physician-scientist faculty to evaluate patients with rare and unusual phenotypes, with the goal of developing testable hypotheses about the underlying mechanisms of disease. They will then use these hypotheses as a rational framework to propose both patient-centered research studies and biologically grounded recommendations for clinical care. During this process, students will gain valuable experience in relating clinical observations to fundamental scientific principles, interpreting molecular data in light of the appropriate clinical and biological context, and communicating the translational implications of their work to clinical and scientific audiences. In addition, they will complete an embedded curriculum that introduces experimental technologies, e.g. exome sequencing, and bioinformatic tools, e.g. genome browsers, that are useful for studying the molecular basis of human disease. This curriculum will be delivered through online lectures and reinforced with hands-on workshops focused on practical application. Preliminary Experience and Use of Funds: For the past 12 months, we have piloted the program with 12 research-oriented clinical clerkship students, including 7 MSTP students. Their response has been overwhelmingly positive, and they have universally agreed that the program provides a unique opportunity to integrate their clinical and basic science training. If funded, this supplement will provide faculty support to continue the pilot and expand it to include MSTP students in their graduate years, magnifying opportunities for interdisciplinary and team-based learning. In addition, a portion of the funding will be used to create the proposed bioinformatics and technology curriculum, which would not otherwise be possible. Given rapid advances in both the clinical and biological sciences, the process of translation has become both more important and more challenging than ever before. This integrative program is a promising new approach that will prepare physician-scientist trainees for careers in translational research.

项目摘要 这是一份医学科学家培训计划（MSTP）T32的行政补充申请 培训补助金。 需求：UCSF MSTP的目标是培养下一代的医生调查员和装备 他们需要研究和临床技能“利用新技术来促进人类健康。” 然而，翻译，即将生物学见解应用于临床问题的过程，反之亦然，是困难的 并且需要独特的技能，而这些技能在医学院或研究生院中是不经常教授的。额外 需要采取综合办法来培养这些重要技能。 该项目：我们将为医生-科学家培训生制定一项创新计划，以培养“床边护理”技能。 通过在病人启发的科学探究中的实践经验，翻译“长凳”和“长凳到床边”。 受训者将与医生科学家密切合作，评估罕见和不寻常的患者。 表型，目的是发展关于疾病的潜在机制的可验证的假设。 然后，他们将使用这些假设作为一个合理的框架，提出以病人为中心的研究， 临床护理的研究和生物学基础的建议。在这个过程中，学生将获得 在将临床观察与基本科学原理联系起来方面的宝贵经验， 根据适当的临床和生物学背景收集数据，并传达翻译含义 向临床和科学观众展示他们的工作。此外，他们将完成嵌入式课程， 介绍了实验技术，例如外显子组测序，和生物信息学工具，例如基因组浏览器， 这对研究人类疾病的分子基础很有用。本课程将通过以下方式提供： 在线讲座，并通过注重实际应用的实践研讨会予以加强。 初步经验和资金使用：在过去的12个月里，我们与12个 研究型临床实习生，包括7名MSTP学生。他们的反应是 他们普遍认为，该计划提供了一个独特的机会， 将临床和基础科学训练结合起来。如果获得资助，该补充将提供教师支持， 继续试点，并将其扩大到包括MSTP学生在他们的研究生年，扩大机会， 跨学科和团队学习。此外，部分资金将用于创建 拟议的生物信息学和技术课程，否则是不可能的。 鉴于临床和生物科学的快速发展，翻译过程已成为 比以往任何时候都更重要，更具挑战性。这种综合方案是一种很有前途的新方法 这将为医学科学家实习生从事转化研究做好准备。