NATIONAL NEUROLOGICAL AIDS BANK

国家神经艾滋病银行

• 批准号: 9901575
• 负责人: ELYSE J SINGER
• 金额: $ 119.09万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-10 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901575
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adverse effects; Age; Aging; Aliquot; Anti-Retroviral Agents; Autopsy; Biological; Blood specimen; Central Nervous System Diseases; Central Nervous System Infections; Cerebrospinal Fluid; Collaborations; Communities; Data; Data Collection; Data Coordinating Center; Databases; Diabetes Mellitus; Enrollment; Equipment and supply inventories; Formalin; Freezing; Future; Geography; Goals; HIV; HIV Infections; HIV Seronegativity; HIV-1; Health; Human; Hyperlipidemia; Immune; Individual; Inflammation; Inflammatory Response; Knowledge; Laboratories; Life; Liquid substance; Long-Term Effects; Longevity; Medical; Mental disorders; Methodology; National NeuroAids Tissue Consortium; Nervous system structure; Neuraxis; Neurocognitive Deficit; Neurologic; Neuropathogenesis; Neuropsychology; Paraffin Embedding; Participant; Pathogenicity; Patients; Penetration; Peripheral; Peripheral Nervous System; Peripheral Nervous System Diseases; Persons; Population; Procedures; Protocols documentation; Provider; Publications; Research; Research Personnel; Resources; Sampling; Site; Slide; Source; Specimen; Standardization; Time; Tissue Donors; Tissue Embedding; Tissue Harvesting; Tissues; United States National Institutes of Health; Vascular Diseases; Viral; Viral reservoir; Work; antiretroviral therapy; biobank; clinical practice; clinical research site; cohort; comorbidity; data exchange; data sharing; data standards; high risk; human tissue; improved; interest; member; mortality risk; nervous system disorder; neuroAIDS; neurotoxic; peer; programs; quality assurance; recruit; research study; restoration; sample collection

Project Summary/Abstract Human immunodeficiency virus (HIV) remains a global threat to human health and an important cause of neurologic and psychiatric disorders, despite advances in longevity due to the use of antiretroviral therapy (ART). ART suppresses HIV replication and allows for partial immune restoration, but may fail to achieve adequate penetration of the central nervous system (CNS). Currently, ART does not eliminate latent HIV, does not clear viral reservoirs, and does not normalize the inflammatory response. Further, some ART may have neurotoxic effects. For these reasons, HIV-associated disorders of the CNS and peripheral nervous system (PNS) have persisted and evolved despite the use of ART in the aging HIV+ population. In order to cure HIV infection of the CNS and to elucidate the pathogenic mechanisms of CNS and PNS disease in ART-treated patients, as well as to continue ongoing studies of aging and HIV co- morbid conditions, NeuroAIDS investigators require a continuous and reliable source of well- characterized human tissues, fluids, and data. These invaluable resources are provided by the National Neurological AIDS Bank (NNAB), a member of the National NeuroAIDS Tissue Consortium (NNTC). Over the past 19 years, the NNAB has enrolled 806 participants, and currently follows a cohort of 171 active participants who have agreed to be tissue donors. Most of our donors have received serial, pre-mortem medical, neurologic, neuropsychologic and laboratory examinations. NNAB has also performed 259 tissue harvests of cohort members. Over the past 5 years, the NNAB has distributed 3,766 frozen tissue specimens, 853 fixed tissue specimens, 23,007 formalin fixed paraffin embedded tissue slides and 3,065 aliquots of fluids to NNTC-approved, qualified investigators. The NNTC is a consortium of 4 geographically dispersed clinical sites and a Data Coordinating Center (DCC). Over the past 5 years, NNTC has collectively fulfilled 123 specimen requests that generated 128 publications. The NNAB actively collaborates with the other NNTC clinical sites and the DCC to develop and maintain standard study protocols, to transfer data to the DCC, to review investigator requests for NNTC resources, and to allocate such resources in a fair and timely fashion. The NNTC works with the DCC to insure we maintain an accurate specimen inventory, and to support the harmonized central NNTC database. The NNAB looks forward to working with our participants, our colleagues, and our requesters for another 5 years to expand and develop this priceless and indispensable scientific resource.

项目总结/文摘