NATIONAL NEUROLOGICAL AIDS BANK

项目摘要/摘要 人类免疫缺陷病毒(HIV)仍然是对人类健康的全球威胁，也是 神经和精神障碍，尽管由于抗逆转录病毒疗法(ART)的使用而延长了寿命。 抗逆转录病毒疗法抑制艾滋病毒复制，并允许部分免疫恢复，但可能无法达到足够的效果 中枢神经系统(CNS)的穿透。目前，抗逆转录病毒疗法不能消除潜伏的艾滋病毒，也不清楚 病毒宿主，并且不能使炎症反应正常化。此外，一些ART可能具有神经毒性 效果。由于这些原因，艾滋病毒相关的中枢神经系统和周围神经系统(PNS)疾病 尽管在老龄化的艾滋病毒人群中使用了抗逆转录病毒疗法，但它仍然存在和发展。 为治疗人类免疫缺陷病毒(HIV)感染中枢神经系统，阐明中枢神经系统的致病机制。 接受抗逆转录病毒治疗的患者的PNS疾病，以及继续正在进行的关于衰老和艾滋病毒联合的研究。 在病态的条件下，神经艾滋病调查人员需要持续和可靠的井源- 表征了人体组织、体液和数据。这些宝贵的资源由 国家神经艾滋病组织联盟成员国家神经艾滋病银行(NNAB (NNTC)。在过去的19年里，NNAB已经招募了806名参与者，目前遵循 171名积极参与者，他们已经同意成为组织捐赠者。我们的大多数捐赠者都有 接受了一系列的尸检、神经学、神经心理学和实验室检查。 NNAB还对队列成员进行了259次组织采集。在过去的5年里，NNAB 分发了3766份冰冻组织标本，853份固定组织标本，23007份福尔马林固定石蜡标本 嵌入组织玻片和3,065等份液体，提供给NNTC批准的合格调查人员。 NNTC是由4个地理上分散的临床站点和一个数据协调中心组成的联合体 (DCC)。在过去的5年里，NNTC总共完成了123份标本请求，产生了128份 出版物。NNAB积极与其他NNTC临床站点和DCC合作开发 并维护标准研究方案，将数据传输到DCC，审查调查人员的请求 NNTC资源，并以公平和及时的方式分配这些资源。NNTC与 DCC确保我们保持准确的标本库存，并支持协调的中央NNTC 数据库。NNAB期待着与我们的参与者、我们的同事和我们的请求者合作 再用5年时间来扩大和开发这一无价之宝和不可或缺的科学资源。

Project Summary/Abstract Human immunodeficiency virus (HIV) remains a global threat to human health and an important cause of neurologic and psychiatric disorders, despite advances in longevity due to the use of antiretroviral therapy (ART). ART suppresses HIV replication and allows for partial immune restoration, but may fail to achieve adequate penetration of the central nervous system (CNS). Currently, ART does not eliminate latent HIV, does not clear viral reservoirs, and does not normalize the inflammatory response. Further, some ART may have neurotoxic effects. For these reasons, HIV-associated disorders of the CNS and peripheral nervous system (PNS) have persisted and evolved despite the use of ART in the aging HIV+ population. In order to cure HIV infection of the CNS and to elucidate the pathogenic mechanisms of CNS and PNS disease in ART-treated patients, as well as to continue ongoing studies of aging and HIV co- morbid conditions, NeuroAIDS investigators require a continuous and reliable source of well- characterized human tissues, fluids, and data. These invaluable resources are provided by the National Neurological AIDS Bank (NNAB), a member of the National NeuroAIDS Tissue Consortium (NNTC). Over the past 19 years, the NNAB has enrolled 806 participants, and currently follows a cohort of 171 active participants who have agreed to be tissue donors. Most of our donors have received serial, pre-mortem medical, neurologic, neuropsychologic and laboratory examinations. NNAB has also performed 259 tissue harvests of cohort members. Over the past 5 years, the NNAB has distributed 3,766 frozen tissue specimens, 853 fixed tissue specimens, 23,007 formalin fixed paraffin embedded tissue slides and 3,065 aliquots of fluids to NNTC-approved, qualified investigators. The NNTC is a consortium of 4 geographically dispersed clinical sites and a Data Coordinating Center (DCC). Over the past 5 years, NNTC has collectively fulfilled 123 specimen requests that generated 128 publications. The NNAB actively collaborates with the other NNTC clinical sites and the DCC to develop and maintain standard study protocols, to transfer data to the DCC, to review investigator requests for NNTC resources, and to allocate such resources in a fair and timely fashion. The NNTC works with the DCC to insure we maintain an accurate specimen inventory, and to support the harmonized central NNTC database. The NNAB looks forward to working with our participants, our colleagues, and our requesters for another 5 years to expand and develop this priceless and indispensable scientific resource.