National Neurological AIDS Bank

国家神经艾滋病银行

• 批准号: 8072130
• 负责人: ELYSE J SINGER
• 金额: $ 143.79万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8072130
• 关键词: AIDS Dementia Complex; Acquired Immunodeficiency Syndrome; Adherence; Aging; Area; Blood; Body Fluids; Cardiovascular Diseases; Cerebrospinal Fluid; Cessation of life; Clinical; Clinical Research; Collaborations; Communities; Comorbidity; Data; Diagnosis; Disease; Epidemiology; Funding; Genetic; Genetic Markers; HIV; HIV Infections; Hepatitis; Impaired cognition; Language; Lead; Leadership; Liquid substance; Longitudinal Studies; Los Angeles; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Medical; Medical Research; Mental disorders; Metabolic Diseases; Methods; Myopathy; National NeuroAids Tissue Consortium; Neurocognitive; Neurologic; Neurovirology; Organ; Pathogenesis; Patients; Peripheral Nervous System Diseases; Persons; Pharmaceutical Preparations; Recruitment Activity; Research; Research Activity; Research Personnel; Resources; Sampling; Scanning; Scientist; Spinal Cord Diseases; Substance abuse problem; Tissues; Tobacco use; Toxic effect; Urine; cohort; human tissue; member; minority subjects; nervous system disorder; volunteer

DESCRIPTION (provided by applicant): This application represents the renewal of the UCLA National Neurological AIDS Bank (NNAB) for an additional 5 years of funding to carry out the resource and research activities of the Bank. Since 1998, NNAB has provided human tissues, fluids, and data for research into the causes and treatment of Neuro-AIDS. NNAB has recruited a racially, ethnically, and linguistically diverse cohort distinctive to and representative of the greater Los Angeles, CA area. We have successfully conducted a longitudinal study of persons with advanced AIDS and HIV-seronegative controls. These subjects have agreed to undergo serial clinical examinations, to donate their blood, urine, and cerebrospinal fluid during their lives, and to donate their tissues and organs after their deaths. A group of subjects also receives separately funded longitudinal magnetic resonance imaging/magnetic resonance spectroscopy scans that add further scientific value to the cohort. Between 2002 and mid-2007 we filled 68 unique requests comprised of tissue and fluids to AIDS researchers worldwide. NNAB also collects information about co-morbid conditions that interact with HIV in the pathogenesis of neurological and psychiatric disorders, and investigates the best methods to detect cognitive impairment in our HIV+ minority subjects. Herein, we describe our new research agenda. We have taken the lead in plans for NNTC co-morbidity research, that will increase the value of the NNTC samples by adding data on aging, hepatitis, metabolic and cardiovascular disorders, tobacco use, adherence, use of non-HIV medications, and by enriching the substance abuse data collected. We have recruited 2 new members to the Scientific Leadership Group who offer expertise in epidemiology and Neuro-AIDS clinical studies. We have developed studies to better diagnose neurocognitive disorders in our diverse cohort, to search for host-genetic markers of AIDS-related neurological and psychiatric disorders, and we have increased our collaborations with investigators who study neurovirology, genetics, toxicity of HIV drugs, and substance abuse. NNAB offers an invaluable resource and research asset to the scientific community and to people afflicted by Neuro-AIDS. Lay Language Summary: The NNAB study recruits and examines donors with AIDS and other diseases. Volunteers agree to donate medical information and samples of their body fluids during their lives, and their tissues and organs after their deaths. This tissue is distributed to worthy scientists for the purpose of medical research. NNAB also conducts its own research into the diagnosis, causes, and cures for neurological diseases associated with HIV infection, such as HIV dementia, myelopathy, peripheral neuropathy, myopathy, psychiatric disorders, and medication toxicity in HIV patients. Part A:

描述(由申请人提供)：此申请代表加州大学洛杉矶分校国家神经艾滋病银行(NNAB)续期5年，以开展该银行的资源和研究活动。自1998年以来，NNAB为研究神经艾滋病的原因和治疗提供了人体组织、体液和数据。NNAB招募了一个种族、民族和语言多样化的队列，该队列具有加利福尼亚州大洛杉矶地区的特色和代表性。我们成功地进行了一项纵向研究，对象是患有 先进的艾滋病和艾滋病毒血清阴性控制。这些受试者同意接受一系列的临床检查，生前捐献他们的血液、尿液和脑脊液，并在他们死后捐献他们的组织和器官。一组受试者还接受单独资助的纵向磁共振成像/磁共振波谱扫描，这将进一步增加队列的科学价值。2002年至2007年年中，我们向世界各地的艾滋病研究人员提出了68项独特的组织和体液请求。NNAB还收集在神经和精神疾病的发病机制中与艾滋病毒相互作用的共病情况的信息，并研究在我们的艾滋病毒+少数民族受试者中检测认知障碍的最佳方法。在这里，我们描述了我们新的研究议程。我们已经率先计划进行NNTC共病研究，这将通过增加关于老龄化、肝炎、代谢和心血管疾病、烟草使用、依从性、非HIV药物使用的数据以及丰富收集的物质滥用数据来增加NNTC样本的价值。我们招募了两名新成员加入科学领导小组，他们提供流行病学和神经艾滋病临床研究方面的专业知识。我们开展了研究，以更好地诊断我们不同队列中的神经认知障碍，寻找艾滋病相关神经和精神疾病的宿主遗传标记，并增加了与研究神经病毒学、遗传学、艾滋病毒药物毒性和物质滥用的研究人员的合作。NNAB为科学界和患有神经艾滋病的人提供了宝贵的资源和研究资产。外行语言摘要：NNAB研究招募并检查患有艾滋病和其他疾病的捐赠者。志愿者同意在他们生前捐赠医学信息和体液样本，并在他们死后捐赠他们的组织和器官。这些组织被分发给有价值的科学家，用于医学研究。NNAB还对与艾滋病毒感染相关的神经系统疾病的诊断、病因和治疗进行自己的研究，如艾滋病毒痴呆症、脊髓病、周围神经病、肌病、精神障碍和艾滋病毒患者的药物毒性。 A部分：