NATIONAL NEUROLOGICAL AIDS BANK

国家神经艾滋病银行

• 批准号: 10355525
• 负责人: ELYSE J SINGER
• 金额: $ 141.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-10 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10355525
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adverse effects; Age; Aging; Aliquot; Anti-Retroviral Agents; Autopsy; Biological; Blood specimen; Central Nervous System Diseases; Central Nervous System Infections; Cerebrospinal Fluid; Collaborations; Communities; Data; Data Collection; Data Coordinating Center; Databases; Diabetes Mellitus; Enrollment; Equipment and supply inventories; Formalin; Freezing; Future; Geography; Goals; HIV; HIV Infections; HIV Seronegativity; HIV-1; Health; Human; Hyperlipidemia; Immune; Individual; Inflammation; Inflammatory Response; Knowledge; Laboratories; Life; Liquid substance; Long-Term Effects; Longevity; Medical; Mental disorders; Methodology; National NeuroAids Tissue Consortium; Nervous system structure; Neuraxis; Neurocognitive Deficit; Neurologic; Neuropathogenesis; Neuropsychology; Paraffin Embedding; Participant; Pathogenicity; Patients; Penetration; Peripheral; Peripheral Nervous System; Peripheral Nervous System Diseases; Persons; Population; Procedures; Protocols documentation; Provider; Publications; Research; Research Personnel; Resources; Sampling; Site; Slide; Source; Specimen; Standardization; Time; Tissue Donors; Tissue Embedding; Tissue Harvesting; Tissues; United States National Institutes of Health; Vascular Diseases; Viral; Viral reservoir; Work; antiretroviral therapy; biobank; clinical practice; clinical research site; cohort; comorbidity; data exchange; data sharing; data standards; high risk; human tissue; improved; interest; member; mortality risk; nervous system disorder; neuroAIDS; neurotoxic; peer; programs; quality assurance; recruit; research study; restoration; sample collection

Project Summary/Abstract Human immunodeficiency virus (HIV) remains a global threat to human health and an important cause of neurologic and psychiatric disorders, despite advances in longevity due to the use of antiretroviral therapy (ART). ART suppresses HIV replication and allows for partial immune restoration, but may fail to achieve adequate penetration of the central nervous system (CNS). Currently, ART does not eliminate latent HIV, does not clear viral reservoirs, and does not normalize the inflammatory response. Further, some ART may have neurotoxic effects. For these reasons, HIV-associated disorders of the CNS and peripheral nervous system (PNS) have persisted and evolved despite the use of ART in the aging HIV+ population. In order to cure HIV infection of the CNS and to elucidate the pathogenic mechanisms of CNS and PNS disease in ART-treated patients, as well as to continue ongoing studies of aging and HIV co- morbid conditions, NeuroAIDS investigators require a continuous and reliable source of well- characterized human tissues, fluids, and data. These invaluable resources are provided by the National Neurological AIDS Bank (NNAB), a member of the National NeuroAIDS Tissue Consortium (NNTC). Over the past 19 years, the NNAB has enrolled 806 participants, and currently follows a cohort of 171 active participants who have agreed to be tissue donors. Most of our donors have received serial, pre-mortem medical, neurologic, neuropsychologic and laboratory examinations. NNAB has also performed 259 tissue harvests of cohort members. Over the past 5 years, the NNAB has distributed 3,766 frozen tissue specimens, 853 fixed tissue specimens, 23,007 formalin fixed paraffin embedded tissue slides and 3,065 aliquots of fluids to NNTC-approved, qualified investigators. The NNTC is a consortium of 4 geographically dispersed clinical sites and a Data Coordinating Center (DCC). Over the past 5 years, NNTC has collectively fulfilled 123 specimen requests that generated 128 publications. The NNAB actively collaborates with the other NNTC clinical sites and the DCC to develop and maintain standard study protocols, to transfer data to the DCC, to review investigator requests for NNTC resources, and to allocate such resources in a fair and timely fashion. The NNTC works with the DCC to insure we maintain an accurate specimen inventory, and to support the harmonized central NNTC database. The NNAB looks forward to working with our participants, our colleagues, and our requesters for another 5 years to expand and develop this priceless and indispensable scientific resource.

项目总结/摘要 人类免疫缺陷病毒（HIV）仍然是对人类健康的全球性威胁，也是导致艾滋病的重要原因。 神经和精神疾病，尽管由于使用抗逆转录病毒疗法（ART）而延长了寿命。 ART抑制HIV复制，并允许部分免疫恢复，但可能无法实现足够的免疫恢复。 穿透中枢神经系统（CNS）。目前，抗逆转录病毒疗法并不能消除潜伏的艾滋病毒， 病毒储库，并且不使炎症反应正常化。此外，一些ART可能具有神经毒性， 方面的影响.由于这些原因，CNS和外周神经系统（PNS）的HIV相关病症具有 尽管在老龄化的HIV+人群中使用了ART，但它仍然持续并发展。 为了治疗中枢神经系统的HIV感染，阐明中枢神经系统的致病机制， PNS疾病在ART治疗的患者，以及继续正在进行的研究老化和艾滋病毒的共同作用， 在病态的情况下，NeuroAIDS研究人员需要一个持续可靠的良好来源， 表征的人体组织、体液和数据。这些宝贵的资源是由 国家神经艾滋病银行（NNAB），国家神经艾滋病组织联盟的成员 （NNTC）。在过去的19年里，NNAB已经招募了806名参与者，目前遵循 171名已同意成为组织供体的积极参与者的队列。我们的大多数捐赠者 接受了一系列的、死前的医学、神经学、神经心理学和实验室检查。 NNAB还对队列成员进行了259次组织收获。在过去的五年里，NNAB 已发放冷冻组织标本3,766份，固定组织标本853份，福尔马林固定石蜡标本23,007份 将包埋的组织切片和3，065等份液体分配给NNTC批准的合格研究者。 NNTC是一个由4个地理上分散的临床研究中心和一个数据协调中心组成的联盟 （DCC）。在过去的5年里，NNTC共完成了123个样本请求，产生了128个 出版物。NNAB积极与其他NNTC临床研究中心和DCC合作， 并维护标准研究方案，将数据传输至DCC，审查研究者的 国家核技术委员会的资源，并以公平和及时的方式分配这些资源。国家核技术委员会与 DCC确保我们保持准确的标本库存，并支持协调的中央NNTC 数据库NNAB期待与我们的参与者，我们的同事和我们的请求者合作 再用5年时间来扩大和发展这一无价和不可或缺的科学资源。