NATIONAL NEUROLOGICAL AIDS BANK

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 为子项目列出的总成本可能 代表子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 本申请代表国家神经艾滋病库（NNAB）的更新，NNAB是国家神经艾滋病组织联盟（NNTC）的成员。NNAB是一项纵向研究，研究对象为特征明确的晚期AIDS和HIV血清阴性（HIV-）受试者，这些受试者同意在其生命期间接受一系列神经系统和神经心理学检查，并同意在其生命期间捐献血液、尿液和脑脊液（CSF），并在其死亡后捐献器官和组织。NNAB收集这些组织和器官，并将其分发给合格的调查人员，用于研究神经艾滋病的发病机制。NNAB使用神经医学、神经心理学、精神病学/物质滥用和神经病理学的标准化NNTC方案对其队列进行表征，以实现由NNTC质量保证委员会监测的共识诊断。此外，NNAB独立收集信息，这是必不可少的研究共病的医疗条件之间的关联，如丙型肝炎病毒（HCV）感染，高血压，糖尿病，血脂紊乱，以及逆转录病毒治疗和艾滋病毒神经系统疾病的不良反应。NNAB队列因其多样性而独特，反映了洛杉矶艾滋病的性别、民族和种族分布。NNAB是85%的男性和15%的女性;超过60%的我们的队列是种族和少数民族的成员，20%是西班牙语单语，8%有不到6年的教育。在这次更新中，我们计划扩大我们的队列，利用我们与加州大学洛杉矶分校医学中心，橄榄景加州大学洛杉矶分校医学中心，查尔斯R。德鲁大学和南加州大学医院。NNAB促进了独立资助项目的发展，这些项目研究CSF病毒载量、HCV和神经系统，以及磁共振波谱（MRS）作为跟踪HIV神经系统疾病的工具。这些项目及其产生的信息进一步丰富了我们组织收藏的价值。NNAB提供了一个日益重要的资源，反映了艾滋病流行的不断变化的面貌，并能够适应调查人员的需要。NNAB为NNTC、科学界和艾滋病患者提供了宝贵的资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This application represents the renewal of National Neurological AIDS Bank (NNAB), a member of the National Neuro-AIDS Tissue Consortium (NNTC). NNAB is a longitudinal study of well-characterized subjects with advanced AIDS and HIV-seronegative (HIV-) subjects, who have agreed to have serial neurological and neuropsychological examinations during their life, and to donate blood, urine and cerebrospinal fluid (CSF) during life and their organs and tissues after their death. NNAB collects these tissues and organs and distributes them to qualified investigators for research into the pathogenesis of Neuro-AIDS. NNAB characterizes its cohort using standardized NNTC protocols in Neuromedicine, Neuropsychology, Psychiatry/Substance Abuse, and Neuropathology, to achieve consensus diagnoses that are monitored by the NNTC Quality Assurance Committees. In addition, NNAB independently collects information that is essential to study the association between co-morbid medical conditions, such as Hepatitis C virus (HCV) infection, hypertension, diabetes, lipid disorders, as well as the adverse effects of retroviral therapy and HIV neurological disease. The NNAB cohort is unique because of its diversity, and reflects the gender, ethnic, and racial distribution of AIDS in Los Angeles. NNAB is 85% male and 15% female; over 60% of our cohort is a member of racial and ethnic minorities, 20% are monolingual in Spanish, and 8% have less than 6 years of education. In this renewal, we plan to expand our cohort, utilizing our collaborations among UCLA Medical Center, Olive View-UCLA Medical Center, Charles R. Drew University, and USC University Hospital. NNAB has stimulated the development of independently funded projects studying CSF viral load, HCV and the nervous system, and magnetic resonance spectroscopy (MRS) as a tool for following HIV neurological disease. These projects and the information they generate further enrich the value of our tissue collection. NNAB provides an increasingly important resource that mirrors the changing face of the AIDS epidemic and is capable of adapting as the needs of investigators dictate. NNAB provides an invaluable resource to the NNTC, the scientific community, and people living with AIDS.