National Neurological AIDS Bank

描述（由申请人提供）：尽管使用高效抗逆转录病毒治疗（HAART）可以延长许多HIV感染者（HIV+）的生存时间，但人类免疫缺陷病毒1型（HIV）仍然是神经和行为疾病（NeuroAIDS）的几乎不可避免的原因。目前HAART治疗方案未能从中枢神经系统中消除HIV，导致了受保护病毒库的发展，新形式的HIV相关神经认知障碍（HAND），以及老年HIV+患者中与年龄相关的神经系统疾病的数量增加。为了解决这些不断发展的问题，研究人员需要从特征良好的人群中获得特征良好的人类中枢神经系统组织和液体。因此，由国家神经艾滋病银行（NNAB）和国家神经艾滋病组织联盟（NNTC）提供的人体组织、体液和数据对于研究人员进行有利于HIV+患者的研究仍然是必不可少的。迄今为止，NNAB已成功招募了719名不同种族、民族、语言和教育背景的参与者，包括男女。我们跟踪了184名活着的参与者，我们进行了228次尸检，其中86%的后代有死前研究数据。我们已经提供了216份组织和数据的请求，并且我们已经在加州大学洛杉矶分校产生了许多独立资助的研究项目，这些项目增加了我们的资源，并进一步推动了神经艾滋病的科学研究。我们积极与其他NNTC临床站点和NNTC数据协调委员会（DCC）合作，维护最新的中央数据库和标本清单，并满足组织、液体和数据的要求。自从NNTC倡议出现以来，我们的参与者的寿命比预期的要长。这产生了新的问题，迫使我们在科学上灵活应变，并迅速适应艾滋病毒流行病不断变化的面貌。相应地，NNAB也有成功的研究项目和合作，与世行相互作用，推动了神经艾滋病领域的发展。我们期待着继续我们的工作，我们的同事在其他临床站点，DCC和NIH，在这个重要的和许多，改变生活的项目。

DESCRIPTION (provided by applicant): Human immunodeficiency virus type-1 (HIV) remains a near-inexorable cause of neurological and behavioral disease (NeuroAIDS) despite the prolonged survival of many HIV-infected (HIV+) individuals associated with use of highly active antiretroviral therapy (HAART). The failure of current HAART regimens to eliminate HIV from the CNS has led to the development of a protected viral reservoir, new forms of HIV associated neurocognitive disorder (HAND), and increasing numbers of age-related neurological disorders in older HIV+ persons. In order to address these evolving issues, investigators require well-characterized human CNS tissues and fluids from well-characterized cohorts. Thus, the human tissues, fluids, and data provided by the National Neurological AIDS Bank (NNAB) and National NeuroAIDS Tissue Consortium (NNTC), remain essential for investigators to perform studies that will benefit HIV+ patients. To date, the NNAB has successfully recruited 719 participants of diverse racial, ethnic, linguistic, and educational backgrounds and both genders. We follow a living cohort of 184 participants, and we have performed 228 autopsies, of which 86% of descendants had pre-mortem study data. We have supplied 216 requests for tissues and data, and we have generated numerous independently funded research projects at UCLA that enhance our resources and further the science of NeuroAIDS. We actively collaborate with the other NNTC clinical sites and the NNTC Data Coordinating Committee (DCC) to maintain an up-to-date central database and specimen inventory and to fulfill requests for tissues, fluids, and data. Since the advent of the NNTC initiative, our participants have lived longer than was anticipated. This has engendered new problems and has forced us to be scientifically nimble and to rapidly adjust to the changing face of the HIV pandemic. The NNAB, adapting in turn, has successful research projects and collaborations that interact with the Bank and advance the very field of NeuroAIDS. We look forward to continuing our work with our colleagues at the other clinical sites, the DCC, and the NIH, on this important and for many, life- changing project.