National Neurological AIDS Bank

国家神经艾滋病银行

• 批准号: 8660709
• 负责人: ELYSE J SINGER
• 金额: $ 116.9万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-10 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8660709
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Address; Age; Aging; Area; Autopsy; Award; Back; Behavioral; Blood; California; Case Report Form; Cerebrospinal Fluid; Climacteric; Collaborations; Collection; Data; Data Collection; Data Coordinating Center; Databases; Development; Dictionary; Disease; Educational Background; Enrollment; Ensure; Epidemic; Equipment and supply inventories; Evolution; Failure; Funding; Future; Gender; Goals; HIV; HIV-1; Highly Active Antiretroviral Therapy; Human; Individual; Language; Life; Linguistics; Liquid substance; Location; Methods; Neurocognitive; Neurologic; Neuropathogenesis; Participant; Patients; Peripheral; Persons; Population; Positioning Attribute; Principal Investigator; Procedures; Process; Quality Control; Recruitment Activity; Regimen; Research; Research Personnel; Research Project Grants; Research Support; Resources; Review Committee; Science; Site; Source; Specific qualifier value; Specimen; Standardization; Tissues; United States National Institutes of Health; Update; Viral; Work; abstracting; age related; base; clinical research site; cohort; data acquisition; high risk; human tissue; improved; meetings; mortality; nervous system disorder; pandemic disease; public health relevance; quality assurance; racial and ethnic; sample collection; tissue resource; trend

DESCRIPTION (provided by applicant): Human immunodeficiency virus type-1 (HIV) remains a near-inexorable cause of neurological and behavioral disease (NeuroAIDS) despite the prolonged survival of many HIV-infected (HIV+) individuals associated with use of highly active antiretroviral therapy (HAART). The failure of current HAART regimens to eliminate HIV from the CNS has led to the development of a protected viral reservoir, new forms of HIV associated neurocognitive disorder (HAND), and increasing numbers of age-related neurological disorders in older HIV+ persons. In order to address these evolving issues, investigators require well-characterized human CNS tissues and fluids from well-characterized cohorts. Thus, the human tissues, fluids, and data provided by the National Neurological AIDS Bank (NNAB) and National NeuroAIDS Tissue Consortium (NNTC), remain essential for investigators to perform studies that will benefit HIV+ patients. To date, the NNAB has successfully recruited 719 participants of diverse racial, ethnic, linguistic, and educational backgrounds and both genders. We follow a living cohort of 184 participants, and we have performed 228 autopsies, of which 86% of descendants had pre-mortem study data. We have supplied 216 requests for tissues and data, and we have generated numerous independently funded research projects at UCLA that enhance our resources and further the science of NeuroAIDS. We actively collaborate with the other NNTC clinical sites and the NNTC Data Coordinating Committee (DCC) to maintain an up-to-date central database and specimen inventory and to fulfill requests for tissues, fluids, and data. Since the advent of the NNTC initiative, our participants have lived longer than was anticipated. This has engendered new problems and has forced us to be scientifically nimble and to rapidly adjust to the changing face of the HIV pandemic. The NNAB, adapting in turn, has successful research projects and collaborations that interact with the Bank and advance the very field of NeuroAIDS. We look forward to continuing our work with our colleagues at the other clinical sites, the DCC, and the NIH, on this important and for many, life- changing project.

描述（由申请人提供）：尽管许多HIV感染（HIV+）个体的生存期延长与使用高效抗逆转录病毒治疗（HAART）相关，但1型人类免疫缺陷病毒（HIV）仍然是神经和行为疾病（NeuroAIDS）的一个近乎不可阻挡的原因。目前HAART方案未能从CNS中消除HIV，导致了受保护的病毒储库的发展，新形式的HIV相关神经认知障碍（HAND），以及老年HIV+患者中年龄相关神经系统疾病数量的增加。为了解决这些不断发展的问题，研究者需要来自充分表征的队列的充分表征的人CNS组织和液体。因此，由国家神经艾滋病库（NNAB）和国家神经艾滋病组织联盟（NNTC）提供的人体组织、体液和数据对于研究人员进行有益于HIV+患者的研究仍然是必不可少的。迄今为止，NNAB已成功招募了719名不同种族、民族、语言和教育背景的男女参与者。我们跟踪了184名参与者的活体队列，我们进行了228次尸检，其中86%的后代有生前研究数据。我们已经提供了216个组织和数据的请求，我们已经在加州大学洛杉矶分校产生了许多独立资助的研究项目，这些项目增加了我们的资源，并进一步促进了神经艾滋病的科学。我们积极与其他NNTC临床研究中心和NNTC数据协调委员会（DCC）合作，以维护最新的中央数据库和标本库存，并满足对组织、液体和数据的要求。自从NNTC倡议出现以来，我们的参与者的寿命比预期的要长。这产生了新的问题，迫使我们在科学上灵活，并迅速适应艾滋病毒流行病不断变化的面貌。NNAB，反过来适应，有成功的研究项目和合作，与银行互动，推进神经艾滋病领域。我们期待着继续我们的工作与我们的同事在其他临床网站，DCC，和国家卫生研究院，对这个重要的和许多，改变生活的项目。