Conduct of studies to evaluate the toxic potential of thallium (I) sulfate in laboratory animals for the National Toxicology Program (NTP)

该项目的目标是为国家毒理学计划(NTP)的危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。需要适当地进行毒理学研究，以确保结果数据是可靠的。该项目涉及在饮用水中暴露后对大鼠和小鼠进行硫酸铊(I)的毒性研究。这种化合物是在饮用水中发现的，因此预计人类会通过这一途径接触到这种化合物。此外，硫酸铊(I)很可能是饮用水中其他铊化合物的代表。该项目的数据将用于就铊对大鼠和小鼠的潜在毒性得出合理的科学结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，公众可充分了解因接触含有五价和四价铊的化学品而产生的危险因素。 关键词：毒性、饮用水、铊

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of thallium (I) sulfate in rats and mice, following exposure in drinking water. This compound is found in drinking water and thus human exposure is anticipated via this route. In addition, thallium (I) sulfate is likely to be representative of other thallium compounds in drinking water. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of thallium in rats and mice and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to chemicals containing pentavalent and tetravalent forms of thallium. Keywords: toxicity, drinking water, thallium