Conduct of studies to evaluate the toxic and potential of vanadyl sulfate and sodium metavanadate in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估硫酸氧钒和偏钒酸钠对实验动物的毒性和潜力

• 批准号: 9915704
• 负责人: BARNEY SPARROW
• 金额: $ 41.52万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2020-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915704
• 关键词: Adverse effects; Chemicals; Chronic; Data; Development; Ensure; Environmental Exposure; Evaluation; Exposure to; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Laboratory Animals; Mus; National Toxicology Program; Phase; Rattus; Reporting; Risk Assessment; Risk Factors; Route; Sodium; Toxic effect; Toxicity Tests; Toxicology; Vanadium; Vanadium Compounds; carcinogenicity; design; disorder prevention; drinking water; exposed human population; public health research; sound; vanadyl sulfate

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of pentavalent (sodium metavanadate) and tetravalent (vanadyl sulfate) vanadium compounds in rats and mice, following exposure in drinking water. These compounds are found in drinking water and thus human exposure is anticipated via this route. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of vanadium in rats and mice and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to chemicals containing pentavalent and tetravalent forms of vanadium. Keywords: toxicity, drinking water, vanadium, pentavalent, tetravalent, vanadyl sulfate, sodium metavanadate.

该项目的目标是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及五价（偏钒酸钠）和四价（硫酸氧钒）钒化合物在大鼠和小鼠接触饮用水后的毒性研究。这些化合物存在于饮用水中，因此预计人类会通过这一途径接触到这些化合物。该项目的数据将用于制定关于钒在大鼠和小鼠中的潜在毒性的合理科学结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，公众可以充分了解因接触含有五价和四价形式钒的化学品而产生的风险因素。 关键词：毒性，饮用水，钒，五价，四价，硫酸氧钒，偏钒酸钠。