Conduct of five day high throughput transcriptomic dose response studies of selected chemicals for the NTP

对 NTP 选定化学品进行为期五天的高通量转录组剂量反应研究

• 批准号: 9915713
• 负责人: BARNEY SPARROW
• 金额: $ 51.86万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2020-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915713
• 关键词: Adult; Apical; Benchmarking; Chemicals; Data; Dose; Exposure to; Genetic Transcription; Liver; Manuscripts; Oral; Phase; Preparation; Rattus; Reporting; Risk Assessment; Toxic effect; cancer genomics; primary endpoint; response; transcriptomics

These studies are being conducted to evaluate the hypothesis that benchmark dose/benchmark doselevel (BMD/BMDL) analyses of transcriptional changes in the adult rat liver following short term oral exposure to a chemical will produce similar (if not slightly lower) points of departure compared to BMD/BMDL analyses of apical end-points. This approach may be useful in comparing classes of compounds and providing quantitative data to inform risk assessments. Keywords: toxicity, high throughput transcriptomics, cancer genomics

进行这些研究的目的是评估以下假设：成年大鼠肝脏短期经口暴露于化学品后转录变化的基准剂量/基准剂量水平（BMD/BMDL）分析与顶端终点的BMD/BMDL分析相比，将产生相似（如果不是略低）的偏离点。这种方法可能有助于比较化合物的类别，并提供定量数据，为风险评估提供信息。 关键词：毒性，高通量转录组学，癌症基因组学