Conduct of five day high throughput transcriptomic dose response studies of selected chemicals for the NTP
Conduct of five day high throughput transcriptomic dose response studies of selected chemicals for the NTP
批准号:
9915713
负责人:
BARNEY SPARROW
金额:
$51.86万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-04-15 至 2020-04-14
中文摘要
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英文摘要
These studies are being conducted to evaluate the hypothesis that benchmark dose/benchmark doselevel (BMD/BMDL) analyses of transcriptional changes in the adult rat liver following short term oral exposure to a chemical will produce similar (if not slightly lower) points of departure compared to BMD/BMDL analyses of apical end-points. This approach may be useful in comparing classes of compounds and providing quantitative data to inform risk assessments.
Keywords: toxicity, high throughput transcriptomics, cancer genomics
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