Conduct of studies to evaluate the toxicity phenolic benzotriazoles (PBZTs) in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估酚类苯并三唑 (PBZT) 对实验动物的毒性

• 批准号: 9915710
• 负责人: BARNEY SPARROW
• 金额: $ 18.16万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2020-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9915710
• 关键词: Adverse effects; Chemicals; Data; Development; Ensure; Environmental Exposure; Exposure to; Gene Expression Profiling; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Laboratory Animals; National Toxicology Program; Pathology; Phase; Phenols; Program Reviews; Rattus; Risk Assessment; Risk Factors; Toxic effect; Toxicity Tests; Toxicology; benzotriazole; carcinogenicity; design; disorder prevention; member; public health research; sound

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves characterization of the toxicity of PBZTs following two-week exposures to nine class members. This project will also permit comparisons among class members. Currently there is little to no toxicity information on this class of compounds. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of PBZTS in rats and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to PBZTs. Keywords: toxicity, phenolic benzotriazoles

该项目的目标是为国家毒理学计划（NTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及PBZTs的毒性特性后，两个星期的曝光9类成员。这个项目还允许在类成员之间进行比较。目前关于这类化合物的毒性信息很少或没有。该项目的数据将用于制定关于PBZTS在大鼠中的潜在毒性和致癌性的合理科学结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，公众可充分了解接触PBZTs所引起的风险因素。 关键词：毒性，酚类苯并三唑