Population genomics of a globally distributed arbovirus vector, Aedes albopictus
全球分布的虫媒病毒载体白纹伊蚊的群体基因组学
基本信息
- 批准号:9921290
- 负责人:
- 金额:$ 61.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-06-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAedesAmericanArbovirusesAreaAsiaBiological ProcessBiological SciencesBiologyChemicalsChikungunya virusClimateCodeCommunitiesComplementCulicidaeDNADataData SetDatabasesDengueDengue VirusDevelopmentDiagnosticDiapauseDiseaseDisease OutbreaksEcologyEpidemiologyFutureGardenalGenesGeneticGenetic DatabasesGenetic MarkersGenetic VariationGenetic VectorsGenomeGenomic SegmentGenomicsGenotypeGeographyGoalsHabitatsHumanIncidenceIndividualInsecticide ResistanceInterdisciplinary StudyKnowledgeLa Crosse encephalitis LinkLocationMeasurementMedicalMonitorNorth AmericaPatternPharmacotherapyPhenotypePhysiologyPopulationPopulation DynamicsPublic HealthRecording of previous eventsResearchResolutionResourcesRiskSNP arraySamplingSeriesSingle Nucleotide PolymorphismSiteSourceStandardizationSurveysTemperatureUntranslated RNAVaccinesViralWorkZIKAZika Virusbasechikungunyacold temperaturecostcost effectivedensitydesigngenome wide association studygenomic biomarkergenomic toolsgeographic differenceimprovedinterestlife historymetropolitannovelphenotypic datapopulation basedscreeningtooltraittranscriptome sequencingurban areavectorvector competencevector controlviral transmissionwhole genome
项目摘要
Project Summary
Aedes albopictus, is an aggressive human-biting mosquito and a competent vector of at least 22 arboviruses,
including dengue, chikungunya, and Zika. Ae. albopictus represents a geographically extensive public health
risk because of its ability to withstand cold temperatures which allow it to spread and establish from the native
tropical regions to temperate localities. This ability to rapidly adapt to different temperature regimes represents
a serious public health concern, especially in heavily populated urban areas of the U.S. where Ae. albopictus
can occur at high densities. Lack of vaccines and drug treatments for most arboviruses makes vector control
the most effective strategy for curbing disease spread.
Our first goal in the proposed research is to develop a new powerful genetic tool for Ae. albopictus, a SNP chip
to efficiently genotype tens of thousands of loci. This tool will address a longstanding knowledge gap due to
the lack of high-resolution genetic markers for Ae. albopictus, and will be useful for a wide range of research
topics from ecology to vector competence. In addition, a recent initiative by Verily Life Sciences (subsidiary of
Google) to sequence 1000 Ae. albopictus will provide another rich source of data for our proposed work. In the
current proposal we will: 1) Perform genetic surveys of worldwide field populations to reconstruct the species
history and to allow rapid identification of the geographic origin(s) or current and future invasions (worldwide
scale); 2) Understand the demographic parameters associated with range expansion on two previously
identified and studied latitudinal transects from tropical to temperate areas in the native and invasive range
(local scale); 3) Construct a publicly accessible standardized database of genetic variation of the species that
can be used to trace future changes in this invasive species range; 4) Collect phenotypic data on diapause
incidence from these samples and use the SNPs to identify genomic regions associated with diapause
incidence to provide novel tools for vector control by disrupting this key trait linked to climatic adaptation.
Results from this research will provide fundamental knowledge on the population dynamics of this important
vector in its native and invasive habitats. The data will also provide practical information to help in the
development and implementation of effective monitoring and control strategies.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PETER ARMBRUSTER其他文献
PETER ARMBRUSTER的其他文献
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{{ truncateString('PETER ARMBRUSTER', 18)}}的其他基金
Population genomics of a globally distributed arbovirus vector, Aedes albopictus
全球分布的虫媒病毒载体白纹伊蚊的群体基因组学
- 批准号:
10661569 - 财政年份:2018
- 资助金额:
$ 61.22万 - 项目类别:
Population genomics of a globally distributed arbovirus vector, Aedes albopictus
全球分布的虫媒病毒载体白纹伊蚊的群体基因组学
- 批准号:
10416022 - 财政年份:2018
- 资助金额:
$ 61.22万 - 项目类别:
The genetic basis of diapause in the Asian tiger mosquito, Aedes albopictus
亚洲虎蚊白纹伊蚊滞育的遗传基础
- 批准号:
8688448 - 财政年份:2014
- 资助金额:
$ 61.22万 - 项目类别:
Massively parallel sequencing of the diapause transcriptome in Aedes albopictus
白纹伊蚊滞育转录组的大规模并行测序
- 批准号:
7739899 - 财政年份:2009
- 资助金额:
$ 61.22万 - 项目类别:
Massively parallel sequencing of the diapause transcriptome in Aedes albopictus
白纹伊蚊滞育转录组的大规模并行测序
- 批准号:
7871476 - 财政年份:2009
- 资助金额:
$ 61.22万 - 项目类别:
MOLECULAR AND QUANTITATIVE VARIATION IN AE ALBOPICTUS
白纹伊蚊的分子和数量变异
- 批准号:
6372889 - 财政年份:2001
- 资助金额:
$ 61.22万 - 项目类别:
MOLECULAR AND QUANTITATIVE VARIATION IN AE ALBOPICTUS
白纹伊蚊的分子和数量变异
- 批准号:
6070427 - 财政年份:2000
- 资助金额:
$ 61.22万 - 项目类别:
MOLECULAR AND QUANTITATIVE VARIATION IN AE ALBOPICTUS
白纹伊蚊的分子和数量变异
- 批准号:
6536044 - 财政年份:2000
- 资助金额:
$ 61.22万 - 项目类别:
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