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Population genomics of a globally distributed arbovirus vector, Aedes albopictus

Population genomics of a globally distributed arbovirus vector, Aedes albopictus
全球分布的虫媒病毒载体白纹伊蚊的群体基因组学
批准号:
10661569
负责人:
PETER ARMBRUSTER
金额:
$38.58万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
未结题
起止时间:
2018-06-01 至 2025-05-31

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中文摘要
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英文摘要
Project Summary Aedes albopictus, is an aggressive human-biting mosquito and a competent vector of at least 22 arboviruses, including dengue, chikungunya, and Zika. Ae. albopictus represents a geographically extensive public health risk because of its ability to withstand cold temperatures which allow it to spread and establish from the native tropical regions to temperate localities. This ability to rapidly adapt to different temperature regimes represents a serious public health concern, especially in heavily populated urban areas of the U.S. where Ae. albopictus can occur at high densities. Lack of vaccines and drug treatments for most arboviruses makes vector control the most effective strategy for curbing disease spread. Our first goal in the proposed research is to develop a new powerful genetic tool for Ae. albopictus, a SNP chip to efficiently genotype tens of thousands of loci. This tool will address a longstanding knowledge gap due to the lack of high-resolution genetic markers for Ae. albopictus, and will be useful for a wide range of research topics from ecology to vector competence. In addition, a recent initiative by Verily Life Sciences (subsidiary of Google) to sequence 1000 Ae. albopictus will provide another rich source of data for our proposed work. In the current proposal we will: 1) Perform genetic surveys of worldwide field populations to reconstruct the species history and to allow rapid identification of the geographic origin(s) or current and future invasions (worldwide scale); 2) Understand the demographic parameters associated with range expansion on two previously identified and studied latitudinal transects from tropical to temperate areas in the native and invasive range (local scale); 3) Construct a publicly accessible standardized database of genetic variation of the species that can be used to trace future changes in this invasive species range; 4) Collect phenotypic data on diapause incidence from these samples and use the SNPs to identify genomic regions associated with diapause incidence to provide novel tools for vector control by disrupting this key trait linked to climatic adaptation. Results from this research will provide fundamental knowledge on the population dynamics of this important vector in its native and invasive habitats. The data will also provide practical information to help in the development and implementation of effective monitoring and control strategies.
期刊论文(11)
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DOI: 10.3897/neobiota.78.84986
发表时间: 2022
期刊: NeoBiota : advancing research on alien species and biological invasions
影响因子: --
作者: [Gloria-Soria A, Shragai T, Ciota AT, Duval TB, Alto BW, Martins AJ, Westby KM, Medley KA, Unlu I, Campbell SR, Kawalkowski M, Tsuda Y, Higa Y, Indelicato N, Leisnham PT, Caccone A, Armstrong PM]
通讯作者: Armstrong PM
DOI: 10.1111/evo.14029
发表时间: 2020-07
期刊: Evolution; international journal of organic evolution
影响因子: --
作者: [Batz ZA, Clemento AJ, Fritzenwanker J, Ring TJ, Garza JC, Armbruster PA]
通讯作者: Armbruster PA
DOI: 10.3390/ijms242015155
发表时间: 2023-10-13
期刊: International journal of molecular sciences
影响因子: 5.6
作者: [Häcker I, Rehling T, Schlosser H, Mayorga-Ch D, Heilig M, Yan Y, Armbruster PA, Schetelig MF]
通讯作者: Schetelig MF
DOI: 10.1073/pnas.2301666120
发表时间: 2023-05-02
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子: 11.1
作者: [Lehmann, T., Bamou, R., Chapman, J. W., Reynolds, D. R., Armbruster, P. A., Dao, A., Yaro, A. S., Burkot, T. R., Linton, Y. -m.]
通讯作者: Linton, Y. -m.
共 7 条
    Population genomics of a globally distributed arbovirus vector, Aedes albopictus
    • 批准号:
      9921290
    • 项目类别:
    • 资助金额:
      $61.22万
    • 财政年份:
      2018
    • 负责人:
      PETER ARMBRUSTER
    • 依托单位:
    Population genomics of a globally distributed arbovirus vector, Aedes albopictus
    • 批准号:
      10416022
    • 项目类别:
    • 资助金额:
      $26.87万
    • 财政年份:
      2018
    • 负责人:
      PETER ARMBRUSTER
    • 依托单位:
    The genetic basis of diapause in the Asian tiger mosquito, Aedes albopictus
    • 批准号:
      8688448
    • 项目类别:
    • 资助金额:
      $46.65万
    • 财政年份:
      2014
    • 负责人:
      PETER ARMBRUSTER
    • 依托单位:
    Massively parallel sequencing of the diapause transcriptome in Aedes albopictus
    • 批准号:
      7739899
    • 项目类别:
    • 资助金额:
      $28.07万
    • 财政年份:
      2009
    • 负责人:
      PETER ARMBRUSTER
    • 依托单位:
    海外基金