Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations

ADRD 风险中的种族/民族差异：社会关系的影响

• 批准号: 9974915
• 负责人: TONI Claudette ANTONUCCI
• 金额: $ 144.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9974915
• 关键词: Adult; Age; Alzheimer' s Disease Pathway; Alzheimer' s disease related dementia; American; Apolipoprotein E; Arabs; Area; Buffers; Characteristics; Cognition; Cognitive; Data; Data Collection; Dimensions; Economic Factors; Economics; Elderly; Electronic Mail; Ethnic Origin; Ethnic group; Genes; Genetic; Genotype; Health; Incidence; Influentials; Intervention; Learning; Life Cycle Stages; Link; Longevity; Longitudinal Studies; Longitudinal cohort study; Measures; Minority Groups; Modeling; Modification; Pattern; Race; Resources; Risk; Risk Factors; Sampling; Spouses; Stress; Structure; Testing; aged; behavior measurement; cohort; comparison group; cost effective; critical period; dementia risk; design; disparity reduction; experience; innovation; member; metropolitan; middle age; novel; protective factors; racial and ethnic; racial and ethnic disparities; recruit; social; social interventions; social structure; socioeconomics; theories; trend

Growing evidence suggests that certain racial/ethnic minority groups experience the highest incidence of Alzheimer’s disease and related dementias (ADRD) risk in the US. Longitudinal studies with diverse samples that collect social and behavioral measures in early and midlife hold exceptional promise for identifying modifiable protective factors for cognitive health and life course pathways of ADRD risk. Social relations, a multidimensional concept with high intervention potential, have been found to predict cognitive health and ADRD, though these associations may differ across race/ethnicity. Still not identified are: (1) how early and mid-life social relations are associated with ADRD risk in different racial/ethnic groups; and (2) specific aspects of social relations that modify ADRD risk. Characterizing how social relations vary as a function of race/ethnicity and clarifying unique links to ADRD risk will advance the field in terms of theory and intervention. This study will leverage three waves of the Social Relations Study plus a fourth wave of the >65 sample (currently in the field: N=330) to examine social relations and ADRD risk across racial/ethnic groups. We will collect a fourth wave of panel data aged <65 (N=244) and a new, representative Detroit metropolitan area sample (N=3400), using the original design, adding Arab Americans to parallel data collection now in the field. Specific aims are: Aim 1: Examine secular trends in social relations and health by race/ethnicity in two adult lifespan regionally representative cohorts. Aim 2: Identify aspects of social relations that have the greatest effects on ADRD risk among blacks, whites and Arab Americans in mid- and late- life. Aim 3: Identify longitudinal associations between social relations across the life course and ADRD risk among blacks and whites. We capitalize on an existing longitudinal cohort study of detailed social relations over ~30 years in a diverse lifespan sample (i.e., from age 8 to 93 in Wave 1). Adding cognitive and genetic measures, as well as extending racial/ethnic group comparisons to include Arab Americans in a new regionally representative sample (age 35+) provides a novel opportunity to study modifiable factors in midlife for ADRD risk. Findings will provide key information to develop strategies using the influential resource of social relations to reduce disparities. Further, the proposed study sets the stage for a newly representative longitudinal study of racial/ethnic disparities in ADRD risk.

越来越多的证据表明，某些种族/族裔少数群体的发病率最高 美国阿尔茨海默病和相关痴呆症 (ADRD) 的风险。多元化的纵向研究 收集早年和中年社会和行为测量的样本对于以下方面具有非凡的前景： 确定认知健康的可改变保护因素和 ADRD 风险的生命过程路径。社会的 关系是一个具有高干预潜力的多维概念，已被发现可以预测认知 健康和ADRD，尽管这些关联可能因种族/民族而异。尚未确定的有： (1) 不同种族/族裔群体的早年和中年社会关系与 ADRD 风险有何关联；和 (2) 改变 ADRD 风险的社会关系的具体方面。描述社会关系如何变化 种族/族裔的功能以及澄清与 ADRD 风险的独特联系将在理论和 干涉。 本研究将利用三轮社会关系研究以及第四轮 >65 岁样本 （目前该领域：N=330）检查跨种族/族裔群体的社会关系和 ADRD 风险。我们将 收集第四波年龄 <65 岁 (N=244) 的面板数据和一个新的、有代表性的底特律大都市区 样本（N = 3400），使用原始设计，将阿拉伯裔美国人添加到现在现场的并行数据收集中。 具体目标是： 目标 1：按种族/族裔检查两个成年人生命周期中社会关系和健康的长期趋势 具有区域代表性的群体。 目标 2：确定对 ADRD 风险影响最大的社会关系方面 中晚年的黑人、白人和阿拉伯裔美国人。 目标 3：确定生命历程中的社会关系与 ADRD 之间的纵向关联 黑人和白人之间的风险。 我们利用现有的纵向队列研究，对约 30 年的详细社会关系进行了研究。 不同寿命样本（即第一波中的 8 岁到 93 岁）。添加认知和遗传测量，以及 扩大种族/族裔群体的比较，将阿拉伯裔美国人纳入新的区域代表中 样本（35 岁以上）提供了一个新的机会来研究中年 ADRD 风险的可改变因素。发现 将提供关键信息，以利用社会关系的有影响力的资源制定战略，以减少 差异。此外，拟议的研究为新的代表性纵向研究奠定了基础 ADRD 风险的种族/民族差异。