Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations

ADRD 风险中的种族/民族差异：社会关系的影响

• 批准号: 10631115
• 负责人: TONI Claudette ANTONUCCI
• 金额: $ 195.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631115
• 关键词: Adult; Age; Alzheimer' s Disease Pathway; Alzheimer' s disease related dementia; American; Apolipoprotein E; Arabs; Area; Black Populations; Buffers; Characteristics; Cognition; Cognitive; Data; Data Collection; Dimensions; Disparity; Economics; Elderly; Electronic Mail; Ethnic Origin; Ethnic Population; Genes; Genetic; Genotype; Health; Incidence; Influentials; Intervention; Learning; Life Cycle Stages; Link; Longevity; Longitudinal Studies; Longitudinal cohort study; Measures; Modeling; Modification; Pattern; Race; Resources; Risk; Risk Factors; Sampling; Socioeconomic Factors; Spouses; Stress; Structure; Testing; aged; behavior measurement; cohort; comparison group; cost effective; critical period; dementia risk; design; disparity reduction; ethnic disparity; ethnic minority population; experience; innovation; member; metropolitan; middle age; novel; protective factors; racial disparity; racial minority population; racial population; recruit; social; social interventions; theories; trend

Growing evidence suggests that certain racial/ethnic minority groups experience the highest incidence of Alzheimer’s disease and related dementias (ADRD) risk in the US. Longitudinal studies with diverse samples that collect social and behavioral measures in early and midlife hold exceptional promise for identifying modifiable protective factors for cognitive health and life course pathways of ADRD risk. Social relations, a multidimensional concept with high intervention potential, have been found to predict cognitive health and ADRD, though these associations may differ across race/ethnicity. Still not identified are: (1) how early and mid-life social relations are associated with ADRD risk in different racial/ethnic groups; and (2) specific aspects of social relations that modify ADRD risk. Characterizing how social relations vary as a function of race/ethnicity and clarifying unique links to ADRD risk will advance the field in terms of theory and intervention. This study will leverage three waves of the Social Relations Study plus a fourth wave of the >65 sample (currently in the field: N=330) to examine social relations and ADRD risk across racial/ethnic groups. We will collect a fourth wave of panel data aged <65 (N=244) and a new, representative Detroit metropolitan area sample (N=3400), using the original design, adding Arab Americans to parallel data collection now in the field. Specific aims are: Aim 1: Examine secular trends in social relations and health by race/ethnicity in two adult lifespan regionally representative cohorts. Aim 2: Identify aspects of social relations that have the greatest effects on ADRD risk among blacks, whites and Arab Americans in mid- and late- life. Aim 3: Identify longitudinal associations between social relations across the life course and ADRD risk among blacks and whites. We capitalize on an existing longitudinal cohort study of detailed social relations over ~30 years in a diverse lifespan sample (i.e., from age 8 to 93 in Wave 1). Adding cognitive and genetic measures, as well as extending racial/ethnic group comparisons to include Arab Americans in a new regionally representative sample (age 35+) provides a novel opportunity to study modifiable factors in midlife for ADRD risk. Findings will provide key information to develop strategies using the influential resource of social relations to reduce disparities. Further, the proposed study sets the stage for a newly representative longitudinal study of racial/ethnic disparities in ADRD risk.

越来越多的证据表明，某些种族/少数民族群体的发病率最高， 阿尔茨海默病和相关痴呆症（ADRD）的风险。纵向研究， 在早期和中年收集社会和行为措施的样本具有特殊的希望， 确定认知健康和ADRD风险的生命过程途径的可改变的保护因素。社会 关系是一个多维度的概念，具有很高的干预潜力，已被发现可以预测认知能力。 健康和ADRD，尽管这些关联可能因种族/民族而异。尚未确定的有： (1)在不同种族/族裔群体中，早期和中年社会关系与ADRD风险的相关性;以及 (2)改变ADRD风险的社会关系的特定方面。社会关系是如何变化的， 种族/民族的功能和澄清ADRD风险的独特联系将在理论和 干预 这项研究将利用社会关系研究的三个浪潮加上>65样本的第四个浪潮 （目前在该领域：N=330），以检查种族/族裔群体之间的社会关系和ADRD风险。我们将 收集第四波年龄<65岁（N=244）的面板数据和一个新的、有代表性的底特律大都市区 样本（N=3400），使用原始设计，将阿拉伯裔美国人添加到目前在该领域的平行数据收集中。 具体目标是： 目标1：按种族/族裔审查两个成年人一生中社会关系和健康的长期趋势 具有区域代表性的群体。 目标2：确定社会关系中对ADRD风险影响最大的方面， 黑人，白人和阿拉伯裔美国人在中年和晚年。 目标3：确定整个生命过程中社会关系与ADRD之间的纵向关联 黑人和白人之间的风险。 我们利用现有的纵向队列研究的详细社会关系超过30年， 不同寿命样本（即，第1波中的8岁至93岁）。增加认知和遗传指标，以及 扩大种族/族裔群体比较，将阿拉伯裔美国人纳入新的区域代表性 样本（年龄35岁以上）提供了一个新的机会，研究在中年ADRD风险的可变因素。结果 将提供关键信息，以制定战略，利用有影响力的社会关系资源， 差距。此外，拟议的研究为一项新的代表性纵向研究奠定了基础， ADRD风险的种族/民族差异。