Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations-Administrative Supplement for Increased Costs

ADRD 风险中的种族/民族差异：社会关系-行政补充对成本增加的影响

• 批准号: 10645901
• 负责人: TONI Claudette ANTONUCCI
• 金额: $ 103.56万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10645901
• 关键词: Address; Administrative Supplement; Adult; Age; Aging; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Apolipoprotein E; Arabs; Area; Assessment tool; Black Populations; Buffers; COVID-19; Characteristics; Cognition; Cognitive; Companions; Data; Data Collection; Disparity; Elderly; Ethnic Origin; Ethnic Population; Family; Friends; Funding; Genes; Genetic; Genotype; Health; Influentials; Intervention; Interviewer; Life Cycle Stages; Link; Long-Term Effects; Longevity; Longitudinal Studies; Longitudinal cohort study; Measures; Modification; Pattern; Phenotype; Preparation; Race; Reporting; Research; Resources; Risk; Risk Factors; Sampling; Scientific Advances and Accomplishments; Socioeconomic Factors; Stress; Testing; Time; Training; Translations; aged; cohort; comparison group; coronavirus disease; coronavirus pandemic; cost; cost effective; critical period; design; disparity reduction; ethnic disparity; experience; human old age (65+); innovation; metropolitan; middle age; novel; pandemic disease; preservation; racial disparity; racial population; recruit; social; social interventions; theories; trend

Increased Costs Supplement- Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations This application for a NIA Administrative Supplement is requested to address the unprecedented cost increases arising from the two-year delay that followed the COVID- 19 mandatory face-to-face data collection shutdown. We note that there has been no change in the original funded scope of the project Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations (R01AG057510). Despite the delay, no intervening research has reduced the importance or uniqueness of the proposed study, which provides an unprecedented opportunity to advance the scientific study of the ways in which cross-sectional and longitudinal patterns of social relations link with disparities in ADRD risk. The specific aims are to: 1) Examine secular trends in social relations and health by race/ethnicity in two adult lifespan regionally representative cohorts; 2) Identify aspects of social relations that have the greatest effects on ADRD risk among blacks, whites and Arab Americans in mid- and late- life; 3) Identify longitudinal associations between social relations across the life course and ADRD risk among blacks and whites. This supplement is submitted to preserve the integrity of the originally approved objectives, purpose and expected overall impact of the study. The two-year COVID delay hit this pioneering study especially hard and has been financially devastating. We capitalize on an existing longitudinal cohort study of detailed social relations over ~30 years in a diverse lifespan sample (i.e., from age 8 to 93 in Wave 1). Adding cognitive and genetic measures, as well as extending racial/ethnic group comparisons to include Arab Americans in a new regionally representative sample (age 35+) provides a novel opportunity to study modifiable factors in midlife for ADRD risk. Findings will provide key information to develop strategies using the influential resource of social relations to reduce disparities. Further, the proposed study sets the stage for a newly representative longitudinal study of racial/ethnic disparities in ADRD risk.

增加的费用补充-种族/民族差异在ADRD风险：影响