Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations-Administrative Supplement for Increased Costs

ADRD 风险中的种族/民族差异：社会关系-行政补充对成本增加的影响

• 批准号: 10645901
• 负责人: TONI Claudette ANTONUCCI
• 金额: $ 103.56万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10645901
• 关键词: Address; Administrative Supplement; Adult; Age; Aging; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Apolipoprotein E; Arabs; Area; Assessment tool; Black Populations; Buffers; COVID-19; Characteristics; Cognition; Cognitive; Companions; Data; Data Collection; Disparity; Elderly; Ethnic Origin; Ethnic Population; Family; Friends; Funding; Genes; Genetic; Genotype; Health; Influentials; Intervention; Interviewer; Life Cycle Stages; Link; Long-Term Effects; Longevity; Longitudinal Studies; Longitudinal cohort study; Measures; Modification; Pattern; Phenotype; Preparation; Race; Reporting; Research; Resources; Risk; Risk Factors; Sampling; Scientific Advances and Accomplishments; Socioeconomic Factors; Stress; Testing; Time; Training; Translations; aged; cohort; comparison group; coronavirus disease; coronavirus pandemic; cost; cost effective; critical period; design; disparity reduction; ethnic disparity; experience; human old age (65+); innovation; metropolitan; middle age; novel; pandemic disease; preservation; racial disparity; racial population; recruit; social; social interventions; theories; trend

Increased Costs Supplement- Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations This application for a NIA Administrative Supplement is requested to address the unprecedented cost increases arising from the two-year delay that followed the COVID- 19 mandatory face-to-face data collection shutdown. We note that there has been no change in the original funded scope of the project Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations (R01AG057510). Despite the delay, no intervening research has reduced the importance or uniqueness of the proposed study, which provides an unprecedented opportunity to advance the scientific study of the ways in which cross-sectional and longitudinal patterns of social relations link with disparities in ADRD risk. The specific aims are to: 1) Examine secular trends in social relations and health by race/ethnicity in two adult lifespan regionally representative cohorts; 2) Identify aspects of social relations that have the greatest effects on ADRD risk among blacks, whites and Arab Americans in mid- and late- life; 3) Identify longitudinal associations between social relations across the life course and ADRD risk among blacks and whites. This supplement is submitted to preserve the integrity of the originally approved objectives, purpose and expected overall impact of the study. The two-year COVID delay hit this pioneering study especially hard and has been financially devastating. We capitalize on an existing longitudinal cohort study of detailed social relations over ~30 years in a diverse lifespan sample (i.e., from age 8 to 93 in Wave 1). Adding cognitive and genetic measures, as well as extending racial/ethnic group comparisons to include Arab Americans in a new regionally representative sample (age 35+) provides a novel opportunity to study modifiable factors in midlife for ADRD risk. Findings will provide key information to develop strategies using the influential resource of social relations to reduce disparities. Further, the proposed study sets the stage for a newly representative longitudinal study of racial/ethnic disparities in ADRD risk.

成本增加补充-ADRD风险中的种族/民族差异：影响 社会关系 此NIA行政补充申请要求解决 由于COVID疫情后两年的延迟而导致的前所未有的成本增加， 19日强制关闭面对面数据采集。我们注意到， ADRD中种族/民族差异项目的原始资助范围发生变化 风险：社会关系的影响（R 01 AG 057510）。尽管延迟，没有干预 研究降低了拟议研究的重要性或独特性， 提供了一个前所未有的机会，以促进科学研究的方式， 社会关系的横截面和纵向模式与以下方面的差距联系在一起： ADRD风险。具体目标是：（1）审查社会关系中的世俗趋势， 在两个成年人寿命区域代表性队列中按种族/族裔分列的健康状况; 2）确定 对黑人ADRD风险影响最大的社会关系方面， 白人和阿拉伯裔美国人在中年和晚年; 3）确定纵向关联 在整个生命过程中的社会关系和黑人和白人之间的ADRD风险之间。 提交本补充材料是为了保持最初批准的 研究的目标、目的和预期的总体影响。两年的COVID 延迟对这项开创性的研究造成了特别严重的打击，并在经济上造成了破坏。我们 利用现有的关于30岁以上详细社会关系的纵向队列研究 不同寿命样本中的年数（即，第1波中的8岁至93岁）。添加认知 和遗传措施，以及扩大种族/族裔群体的比较，包括 阿拉伯裔美国人在一个新的区域代表性样本（35岁以上）提供了一个新的 研究中年ADRD风险的可改变因素的机会。调查结果将提供关键 利用社会关系这一有影响力的资源制定战略， 减少差距。此外，拟议的研究为新的代表性研究奠定了基础。 ADRD风险中种族/民族差异的纵向研究。