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Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations

ADRD 风险中的种族/民族差异：社会关系的影响

基本信息

批准号：
10474964
负责人：
TONI Claudette ANTONUCCI
金额：
$ 152.48万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10474964
关键词：
Adult Age Alzheimer&apos s Disease Pathway Alzheimer&apos s disease related dementia American Apolipoprotein E Arabs Area Black Populations Buffers Characteristics Cognition Cognitive Data Data Collection Dimensions Economics Elderly Electronic Mail Ethnic Origin Ethnic group Genes Genetic Genotype Health Incidence Influentials Intervention Learning Life Cycle Stages Link Longevity Longitudinal Studies Longitudinal cohort study Measures Modeling Modification Pattern Race Resources Risk Risk Factors Sampling Socioeconomic Factors Spouses Stress Structure Testing aged behavior measurement cohort comparison group cost effective critical period dementia risk design disparity reduction ethnic minority population experience innovation member metropolitan middle age novel protective factors racial and ethnic racial and ethnic disparities recruit social social interventions social structure theories trend

项目摘要

Growing evidence suggests that certain racial/ethnic minority groups experience the highest incidence of Alzheimer’s disease and related dementias (ADRD) risk in the US. Longitudinal studies with diverse samples that collect social and behavioral measures in early and midlife hold exceptional promise for identifying modifiable protective factors for cognitive health and life course pathways of ADRD risk. Social relations, a multidimensional concept with high intervention potential, have been found to predict cognitive health and ADRD, though these associations may differ across race/ethnicity. Still not identified are: (1) how early and mid-life social relations are associated with ADRD risk in different racial/ethnic groups; and (2) specific aspects of social relations that modify ADRD risk. Characterizing how social relations vary as a function of race/ethnicity and clarifying unique links to ADRD risk will advance the field in terms of theory and intervention. This study will leverage three waves of the Social Relations Study plus a fourth wave of the >65 sample (currently in the field: N=330) to examine social relations and ADRD risk across racial/ethnic groups. We will collect a fourth wave of panel data aged <65 (N=244) and a new, representative Detroit metropolitan area sample (N=3400), using the original design, adding Arab Americans to parallel data collection now in the field. Specific aims are: Aim 1: Examine secular trends in social relations and health by race/ethnicity in two adult lifespan regionally representative cohorts. Aim 2: Identify aspects of social relations that have the greatest effects on ADRD risk among blacks, whites and Arab Americans in mid- and late- life. Aim 3: Identify longitudinal associations between social relations across the life course and ADRD risk among blacks and whites. We capitalize on an existing longitudinal cohort study of detailed social relations over ~30 years in a diverse lifespan sample (i.e., from age 8 to 93 in Wave 1). Adding cognitive and genetic measures, as well as extending racial/ethnic group comparisons to include Arab Americans in a new regionally representative sample (age 35+) provides a novel opportunity to study modifiable factors in midlife for ADRD risk. Findings will provide key information to develop strategies using the influential resource of social relations to reduce disparities. Further, the proposed study sets the stage for a newly representative longitudinal study of racial/ethnic disparities in ADRD risk.

越来越多的证据表明，某些种族/少数民族群体的发病率最高