Translational Breast Cancer Research Training Program

转化乳腺癌研究培训计划

• 批准号: 9977965
• 负责人: MATTHEW J ELLIS
• 金额: $ 21.19万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9977965
• 关键词: Research Training; Training Programs; malignant breast neoplasm

Abstract Improvements in the outcome for women with breast cancer require an emerging new breed of investigator, the translational researcher. Scientists with a strong foundation in basic molecular and cellular research who also have an understanding of the clinical disease course will direct the most effective future of breast cancer research. Such investigators have been called “translational” because of their ability to translate basic findings into clinical strategies and vice versa. This type of training requires both a well-funded core of investigators performing basic laboratory research, and an excellent clinical training program. At Baylor College of Medicine, the Breast Center affords such a combination. This is a new application for a formal Training Program that began in 1999 when what is now the Smith Breast Center was formed. All trainees work on a focused aspect of breast cancer research including 1)Hormone Action/Endocrine Therapy 2)Molecular Genomics 3)Growth Factors/Signal Transduction 4)Normal Breast Development/Breast Cancer Prevention and 5)Novel Treatment Strategies. Formal didactic courses covering Scientific writing, research grants, Biostatistics, Leadership skills, Molecular carcinogenesis, and problems in clinical translational breast cancer research are required. Progress and direction of the trainee's research project are closely monitored in bimonthly Research and Development workshops.

摘要 改善乳腺癌妇女的预后需要一种新的 研究者，翻译研究者。在基础分子生物学方面有着坚实基础的科学家 和细胞研究谁也有一个了解临床疾病的过程将直接 乳腺癌研究最有效的未来。这些调查人员被称为 “翻译”，因为他们有能力将基本发现转化为临床策略， 亦然这类培训既需要资金充足的调查员核心， 实验室研究和出色的临床培训计划。在贝勒医学院 乳房中心提供了这样的组合。这是一个新的应用程序的正式培训 该计划始于1999年，当时成立了现在的史密斯乳腺中心。所有学员 乳腺癌研究的重点方面，包括1）激素作用/内分泌 治疗2）分子基因组学3）生长因子/信号转导4）正常乳腺 发展/乳腺癌预防和5）新的治疗策略。正式 教学课程包括科学写作，研究赠款，生物统计学，领导技能， 分子致癌作用，以及临床转化乳腺癌研究中的问题， 必需的.学员的研究计划的进度和方向，会在 双月研究与发展讲习班。