Behavior Automation
行为自动化
基本信息
- 批准号:9983196
- 负责人:
- 金额:$ 14.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-28 至 2022-07-31
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAreaAutomationBehaviorBehavioral ResearchBrainCommunitiesComputer ModelsComputer softwareConsumptionDecision MakingDocumentationEnsureFailureHeadHealthHome environmentHourHuman ResourcesIndividualInfrastructureInstructionInterventionJapanLaboratoriesLettersManualsMindMonitorMusNeurosciencesPractice ManagementProceduresProcessProtocols documentationQuality ControlRattusReproducibilityResearchResearch PersonnelResearch Project GrantsRodentRunningSensoryShort-Term MemorySoftware ToolsStandardizationSystemTimeTrainingbasecognitive abilitycognitive taskcost effectivedata acquisitiondesignexperienceexperimental studyimage registrationimprovedneural circuitneuromechanismopen sourceoperationpreventscale upsoftware developmentsupport toolstoolvirtualvirtual realityvirtual reality system
项目摘要
Project Summary: Core 3, Behavior Automation
Working memory, the ability to temporarily hold multiple pieces of information in mind for
manipulation, is central to virtually all cognitive abilities. This multi-component research project
aims to comprehensively dissect the neural circuit mechanisms of this ability across multiple
brain areas. The individual parts of the project cohere conceptually, in part, because they all
involve rodents trained to perform a type of decision-making task that is based on the gradual
accumulation of sensory evidence and thus relies on working memory. To produce enough
subjects for these experiments, this Core will scale up an existing high-throughput rat training
facility run by technicians and adapt it for mice. This expansion will quintuple the project’s
capacity for rodent training. To do so, we will take advantage of the expertise of the project
leader in developing and managing such a training facility for sophisticated cognitive tasks in
an existing virtual reality infrastructure, software, and hardware. Once this facility is operational,
the Core will manage it and troubleshoot problems as needed. It will develop new hardware
and software components for training rigs to make technician interventions as reproducible and
error-free as possible. Because the most crucial and time-consuming aspect of mouse virtual
training is ensuring that the head-fixed animal is properly aligned to the ball and the projection
system, the Core will develop an automated alignment system based on image registration and
actuators to replace the current manual alignment. It will develop software tools and
standardized technician procedures to ensure consistency in rodent training, prevent training
errors, detect hardware failures, and monitor the health of the animals. This centralized facility
will promote rigor and reproducibility by reducing variability in animal training across labs,
increase the rate of data acquisition, and free personnel to focus on designing and carrying out
creative experiments. In the long run, the entire neuroscience community will benefit from this
effort, as the software and hardware tools and management protocols produced will be made
freely available, along with their documentation. These tools will enable other researchers to
introduce automated training for well-controlled cognitive tasks in their own laboratories,
leading to improved efficiency, rigor, and reproducibility in behavioral research across the field
of neuroscience.
项目总结:核心3,行为自动化
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Carlos D Brody其他文献
Carlos D Brody的其他文献
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{{ truncateString('Carlos D Brody', 18)}}的其他基金
P2: Geometry of Neural Representations and Dynamics
P2:神经表征和动力学的几何
- 批准号:
10705964 - 财政年份:2023
- 资助金额:
$ 14.04万 - 项目类别:
Mechanisms of neural circuit dynamics in working memory and decision-making
工作记忆和决策中的神经回路动力学机制
- 批准号:
10705962 - 财政年份:2023
- 资助金额:
$ 14.04万 - 项目类别:
An experimental platform to investigate the neural mechanisms underlying flexible decision-making
研究灵活决策神经机制的实验平台
- 批准号:
10366077 - 财政年份:2021
- 资助金额:
$ 14.04万 - 项目类别:
Mechanisms of neural circuit dynamics in working memory anddecision-making
工作记忆和决策中的神经回路动力学机制
- 批准号:
9983177 - 财政年份:2017
- 资助金额:
$ 14.04万 - 项目类别:
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