Pediatric Infectious Diseases and Immunity Training Program

项目总结 本申请建议更新儿科传染病博士后培训计划，并 免疫学(PIDI-TP)，以儿科传染病(ID)和风湿科为基础，网址： 华盛顿大学医学院和圣路易斯儿童医院。长期目标是培训 学术内科医生-科学家将在儿科传染病发病机制和宿主方面开展有影响力的研究 回应。WUSM为内科科学家提供了一个出色的培训环境，拥有国家认可的 医院与国家一流的生物医学研究设施相连。许多华盛顿大学 儿科内外的教职员工都是传染病研究的带头人 疾病和人类免疫学。PIDI-TP还将利用WUSM广泛的基因组设施 测序和微生物基因组学，以及100个其他研究核心。我们的35位PIDI-TP导师，来自 儿科、内科、病理学/免疫学和分子微生物学系具有很强的代表性 拥有外部资助的研究项目和指导医生的经验的成功研究人员- 科学家。PIDI-TP项目主任(PD)将由医学博士David Hunstad担任，他是儿科学和 儿科ID科主任。共同PD将是Tony French，医学博士，儿科学副教授 儿科风湿科主任。这两个PD还指导儿科医生-科学家 WUSM的培训计划(PSTP)。计划活动和结果、学员选择和学员进度将 由WUSM的两名PD和其他四名终身调查员组成的执行委员会监督 他们积极参与医生-科学家的培训，并由来自全国的外部教员提供建议 儿科ID或免疫学方面的公认专家。每位学员将获得一份个性化的奖学金。 监督委员会(SOC)，其调查结果将由私营部门和执行委员会审查。该计划 将每年支持两名博士后(医学博士或医学博士/博士)实习生，从儿科奖学金计划中招募 传染病，风湿病，过敏/免疫学，以及新生儿学，肺部医学， 肾病和重症护理，特别是在我们强大的PSTP渠道中吸引医学/博士实习生。超越了 为学员组织的指导研究经验、教育和职业发展活动分为三个部分 竞技场：病原体、宿主和欧米克。所有参与者的核心课程将提供研究设计方面的培训， 生物统计学、人类受试者研究、动物使用和护理、科学写作、拨款准备和基因组学。 受训者还将接受广泛的持续指导，以进行职业规划并为专业小组委员会做准备 考试。职业发展将由研究导师、个人发展计划、执行委员会、 以及SOC。计划评估将依赖于短期和长期指标以及来自当前和 过去的实习生。概述了为加强学员和导师之间的多样性所作的努力。

PROJECT SUMMARY This application proposes the renewal of a post-doctoral training program in pediatric infectious diseases and immunology (PIDI-TP), based in the Divisions of Pediatric Infectious Diseases (ID) and Rheumatology at Washington University School of Medicine and St. Louis Children’s Hospital. The long-term objective is to train academic physician-scientists to carry out impactful research in pediatric infectious disease pathogenesis and host response. WUSM offers an outstanding training environment for physician-scientists, with nationally recognized hospitals conjoined with one of the nation’s premier biomedical research facilities. Many Washington University faculty members, both within and outside the Department of Pediatrics, are leading investigators in infectious diseases and human immunology. PIDI-TP will also take advantage of extensive WUSM facilities for genome sequencing and microbial genomics, as well as 100 other Research Cores. Our 35 PIDI-TP mentors, drawn from the Departments of Pediatrics, Medicine, Pathology/Immunology, and Molecular Microbiology, represent highly successful investigators with externally funded research programs and experience in mentoring physician- scientists. The PIDI-TP Program Director (PD) will be David Hunstad, MD, Associate Professor of Pediatrics and Chief of the Division of Pediatric ID. The co-PD will be Tony French, MD, PhD, Associate Professor of Pediatrics and Chief of the Division of Pediatric Rheumatology. These two PDs also direct the Pediatric Physician-Scientist Training Program (PSTP) at WUSM. Program activities and outcomes, trainee selection, and trainee progress will be overseen by an Executive Committee consisting of the two PDs and four other tenured investigators at WUSM who are heavily involved in physician-scientist training, and advised by external faculty who are nationally recognized experts in pediatric ID or immunology. Each trainee will be advised by an individualized Scholarship Oversight Committee (SOC), whose findings will be reviewed by the PDs and Executive Committee. The program will support two postdoctoral (MD or MD/PhD) trainees per year, to be recruited from pediatric fellowship programs in Infectious Diseases, Rheumatology, and Allergy/Immunology, as well as Neonatology, Pulmonary Medicine, Nephrology, and Critical Care, drawing in particular on MD/PhD trainees in our robust PSTP pipeline. Beyond the mentored research experience, educational and career development activities for trainees are organized in three arenas: Pathogens, Host, and Omics. A Core Curriculum for all participants will provide training in study design, biostatistics, human subjects research, animal use and care, scientific writing, preparation of grants, and genomics. Trainees will also receive extensive ongoing mentoring for career planning and to prepare for subspecialty Board examinations. Career development will be monitored by research mentors, the PDs, the Executive Committee, and the SOCs. Program evaluation will rely on short-term and long-term metrics as well as input from current and past trainees. Efforts are outlined to enhance diversity among trainees and mentors.