Voice and Speech Sensorimotor Control in Parkinsons Disease

帕金森病的声音和言语感觉运动控制

• 批准号: 10361306
• 负责人: FRANK H GUENTHER
• 金额: $ 47.9万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-16 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10361306
• 关键词: Address; Affect; Articulation; Auditory; Behavior Therapy; Behavioral; Brain; Communication; Conflict (Psychology); Data; Development; Device Designs; Disease Progression; Dysarthria; Effectiveness; Elderly; Environment; Feedback; Financial compensation; Frequencies; Functional Magnetic Resonance Imaging; Future; Hearing; Heterogeneity; Impairment; Incidence; Individual; Jaw; Larynx; Learning; Link; Loudness; Magnetic Resonance Imaging; Measures; Modality; Modeling; Modification; Movement; Nerve Degeneration; Operative Surgical Procedures; Outcome; Parkinson Disease; Participant; Patients; Physiological; Production; Quality of life; Science; Sensory; Severity of illness; Speech; Speech Intelligibility; Speech Therapy; Symptoms; System; Testing; Time; Update; Voice; Work; auditory feedback; base; behavior measurement; cohort; deviant; effective therapy; experimental study; functional outcomes; improved; indexing; motor control; motor deficit; motor learning; multidisciplinary; neuroimaging; neuroregulation; new therapeutic target; relating to nervous system; response; somatosensory

Project Summary: Over 90% of individuals with Parkinson's disease (PD) suffer from speech problems characterized by impairments of voice and articulation, collectively termed “hypokinetic dysarthria”. These symptoms degrade speakers' functional communication through decreases in both naturalness and intelligibility. However, little is known about the relationship between these functional communication outcomes and their underlying neural sensorimotor bases. While previous work has evaluated disparate aspects of speech motor control in modest cohorts, the result thus far is a patchwork of seemingly conflicting information. To address this gap, this project will comprehensively examine the sensorimotor control of speech in PD in a single cohort, utilizing the DIVA model [34] as a theoretical framework to guide hypothesis development and allow for mechanistic interpretations of experimental findings. Feedback and feedforward mechanisms of speech motor control affecting both voice (larynx) and articulation (vocal tract) will be evaluated in 40 individuals with PD and 40 matched control speakers using behavioral and neural responses to perturbations in somatosensory and auditory feedback. Our primary hypotheses are that PD involves weaker-than-normal feedforward commands, leading to increased reliance on feedback control, as well as an impaired ability to update feedforward commands based on discrepancies between desired and actual movement outcomes. Comprehensive sensorimotor control parameters from each participant will be compared with their intelligibility and naturalness, determined through rigorous auditory- perceptual experiments. Identification of the specific sensorimotor bases of speech symptoms in PD are essential to guide the development of new therapeutic targets to improve communication. For instance, although speech therapy is the only current treatment, only 13% of patients with PD choose to pursue it, likely due to its low long-term effectiveness. Given the relatively slow progression of PD and the increased incidence of speech symptoms with disease progression, developing effective speech treatments is imperative for maintaining quality of life. This project will result in specific physiological markers that are linked to functional communication outcomes in PD and can act as critical targets for behavioral and surgical interventions. This will lead to new treatments that are specific, effective, and tied to functional communication outcomes.

项目总结： 超过90%的帕金森氏病(PD)患者患有言语问题，其特征是 发音和发音障碍，统称为“运动性构音障碍”。这些症状会恶化 说话人的功能性交际通过自然度和可理解性的降低来实现。然而，几乎没有什么是 了解这些功能性交流结果与其潜在神经之间的关系 感应器运动基地。虽然之前的工作评估了言语运动控制的不同方面 到目前为止，结果是由似乎相互矛盾的信息拼凑而成的。为了解决这一差距，这个项目 我将利用DIVA在单个队列中全面检查帕金森病患者的言语感觉运动控制 模型[34]作为指导假说发展和允许机械解释的理论框架 实验结果。影响两种语音的言语运动控制的反馈和前馈机制 将对40名帕金森病患者和40名匹配的对照说话者进行喉部和发音(声道)的评估 在躯体感觉和听觉反馈中使用对扰动的行为和神经反应。我们的初选 假设PD涉及比正常更弱的前馈命令，从而导致更多的依赖 反馈控制，以及基于差异更新前馈命令的能力受损 在期望的运动结果和实际的运动结果之间。全面的感应器电机控制参数 参与者将被与他们的可理解性和自然度进行比较，这是通过严格的听觉- 感性实验。帕金森病患者言语症状的特异性感觉运动基础识别 这对于指导开发新的治疗靶点以改善沟通至关重要。例如，尽管 言语疗法是目前唯一的治疗方法，只有13%的帕金森病患者选择使用它，这可能是因为它 长期效果不佳。鉴于帕金森病进展相对缓慢，言语发生率增加 症状随着疾病的进展，开发有效的语音治疗方法是保持质量的当务之急 生活的一部分。这个项目将产生特定的生理标记，这些标记与功能交流有关 帕金森病的预后，可作为行为和手术干预的关键靶点。这将导致新的 具体、有效并与功能性沟通结果挂钩的治疗方法。

项目成果

Assessing Ecologically Valid Methods of Auditory Feedback Measurement in Individuals With Typical Speech.

• DOI: 10.1044/2021_jslhr-21-00377
• 发表时间: 2021-12
• 期刊: Journal of speech, language, and hearing research : JSLHR
• 作者: Nicole E Tomassi;Hasini R. Weerathunge;Megan R Cushman;J. Bohland;C. Stepp

Contributions of Auditory and Somatosensory Feedback to Vocal Motor Control.

听觉和体感反馈对发声运动控制的贡献。

• DOI: 10.1044/2020_jslhr-19-00296
• 发表时间: 2020
• 期刊: Journal of speech, language, and hearing research : JSLHR
• 作者: Smith,DanteJ;Stepp,Cara;Guenther,FrankH;Kearney,Elaine
• 通讯作者: Kearney,Elaine

Neurocomputational modeling of speech motor development.

言语运动发育的神经计算模型。

• DOI: 10.1017/s0305000923000260
• 发表时间: 2023
• 期刊: Journal of child language
• 影响因子: 2.2
• 作者: Meier,AndrewM;Guenther,FrankH
• 通讯作者: Guenther,FrankH

Oral configurations during vowel nasalization in English.

• DOI: 10.1016/j.specom.2021.02.005
• 发表时间: 2021-05
• 期刊: Speech communication
• 影响因子: 3.2
• 作者: Cler GJ;Perkell JS;Stepp CE
• 通讯作者: Stepp CE

Effects of a Concurrent Working Memory Task on Speech Acoustics in Parkinson's Disease.

并行工作记忆任务对帕金森病语音声学的影响。

• DOI: 10.1044/2023_ajslp-23-00214
• 发表时间: 2024
• 期刊: American journal of speech-language pathology
• 影响因子: 2.6
• 作者: Dragicevic,DariaA;Dahl,KimberlyL;Perkins,Zoe;Abur,Defne;Stepp,CaraE
• 通讯作者: Stepp,CaraE