Clinical Studies and LN FNA Core

临床研究和 LN FNA 核心

基本信息

批准号：
10371991
负责人：
Alessandro Sette
金额：
$ 45.24万
依托单位：
LA JOLLA INSTITUTE FOR IMMUNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-11 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10371991
关键词：
Adherence Adult Antigens Axilla B-Lymphocytes Bacteria Biopsy Blood Blood donor Blood specimen CD4 Positive T Lymphocytes Cells Child Clinical Clinical Research Code Collaborations Diagnosis Ensure Epigenetic Process Fine needle aspiration biopsy Foundations Goals Human Human Herpesvirus 4 Immunization Immunize Individual Institutional Review Boards Lung Lymph Node Tissue Maintenance Malignant neoplasm of lung Mediastinal lymph node group Operative Surgical Procedures Pathologic Patients Pattern Pediatric Hospitals Peripheral Blood Mononuclear Cell Pertussis Pertussis Vaccine Plasma Plasma Cells Preparation Procedures Protocols documentation Quality Control Recurrence Research Institute Resected Resources Role Sampling Sampling Studies Secondary to Site Source Streptococcus pyogenes Structure of parenchyma of lung T cell response Tissue Sample Tissues Tonsil Tonsillectomy Tonsillitis Translational Research Vaccinated Vaccinee Vaccines Virus Virus Diseases Work Yellow Fever Vaccine Yellow fever virus cohort cytotoxic design draining lymph node expectation infancy lymph node biopsy lymph nodes minimally invasive programs recruit research study response retention rate success tumor ultrasound

项目摘要

CLINICAL STUDIES AND LN FNA CORE (CORE B) CORE SUMMARY The success of the entire program is contingent upon successful accrual of human samples. We are confident in our ability to amass the necessary samples that will enable the most robust and compelling studies. The Clinical Studies and LN FNA Core will provide a centralized resource for accrual of human lymph node (LN), lung, peripheral blood mononuclear cells (PBMC) and plasma samples, and ensure the quality and uniformity of handling of the samples received. These functions are crucial to provide a strong foundation for the studies described in the three proposed projects. The Clinical Studies and LN FNA Core will work closely with the individual Projects, the Administrative Core, the Sequencing and Epigenetics Core, and the clinical subcontractors to enable success of all objectives in this program proposal. This Core will be responsible for the preparation and maintenance of IRB protocols, oversight of subject recruitment, quality control of coded clinical information and donor samples. The cohorts to be used for this program include samples from well- regarded and successful collaborators and clinicians. We will work closely with Drs. F. Hasteh (UCSD) and S. Yekezare (UCSD) and the Altman Clinical and Translational Research Institute (ACTRI) at UCSD to enable acquisition of lymph node fine needle aspirate (LN FNA) samples for Projects 1, 2 and 3. We have a long- standing collaboration with Dr. M.T. Brigger (Rady Children's, UCSD) to obtain tonsil samples to be used for Projects 1 and 3. We also will collaborate with Dr. Ottensmeier (Southampton, UK) to obtain lung and lung- draining lymph node tissue samples for Projects 1 and 3. LJI's in-house Clinical Core will manage the banked samples from vaccinated individuals for Project 2 and will provide all new samples from pertussis- and yellow fever virus-vaccinated donors needed for Projects 1, 2 and 3.

临床研究和LN FNA核心（核心B）核心摘要整个计划的成功取决于人类样本的成功应计。我们有信心为了积累必要的样本，可以实现最强大，最引人注目的研究。这临床研究和LN FNA核心将为人类淋巴结（LN）的应计资源提供集中资源，肺，外周血单核细胞（PBMC）和血浆样品，并确保质量和均匀性处理样品的处理。这些功能对于为研究提供坚实的基础至关重要在提议的三个项目中描述。临床研究和LN FNA核心将与个别项目，行政核心，测序和表观遗传学核心以及临床分包商在此计划提案中使所有目标取得成功。这个核心将负责 IRB协议的准备和维护，对主题招聘的监督，编码的质量控制临床信息和供体样本。该程序用于该程序的同类包括来自良好的样本被关注并成功的合作者和临床医生。我们将与Drs紧密合作。 F. Hasteh（UCSD）和S. Yekezare（UCSD）和UCSD的Altman临床和翻译研究所（ACTRI）启用为项目1、2和3的淋巴结淋巴结抽吸物（LN FNA）样品的采集。我们有很长的与M.T.博士合作Brigger（Rady Children's，UCSD）获取用于使用的扁桃体样品项目1和3。我们还将与Ottensmeier博士（英国南安普敦）合作获得肺和肺项目1和3的排水淋巴结组织样品。LJI的内部临床核心将管理银行来自接种疫苗的个人的样本，用于项目2，将提供百日咳和黄色的所有新样本项目1、2和3所需的发烧病毒疫苗接种供体。