Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination

多年来，我们团队开发了一套数据标准，以捕获免疫的不同方面 简档研究，能够描述例如正在研究的免疫暴露(例如，类型 和感染过程或接种疫苗)或在细胞分析中测量的分子标记以及如何 它们将检测到的细胞与特定的细胞类型相关联。这些标准主要是为人类制定的 免疫学项目联盟(HIPC)，并为与ImmPort提交的互操作而量身定做 在该系统中，它们已被采纳，现在用于向ImmPort提交的所有数据。为 这些标准使跨中心的数据分析项目和方法开发成为可能。作为一部分 在这项工作中，已经创建了自动验证例程来测试其ImmPort数据提交 遵守这些数据标准，使我们能够识别和纠正数据中的问题 提交..

Our group has developed a set of data standards over the years to capture different aspects of immune profiling studies that enable the description of, for example, the immune exposure being studied (e.g. type and course of infection or vaccination) or the molecular markers measured in a cytometry assay and how they relate detected cells to specific cell types. These standards were primarily developed for the Human Immunology Project Consortium (HIPC), and were tailored to be interoperable with the ImmPort submission system, in which they have been adopted and are now used for all data submissions into ImmPort. For HIPC, these standards have enabled cross-center data analysis projects and method development. As part of this work, automated validation routines have been created that test ImmPort data submissions for their adherence to these data standards, which has enabled us to identify and correct issues in data submissions..