Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination

感染、疾病和疫苗接种中登革热病毒和结核分枝杆菌暴露的人体免疫特征

• 批准号: 10228367
• 负责人: Alessandro Sette
• 金额: $ 29.28万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-02 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10228367
• 关键词: Adherence; Adopted; Adult; Biological Assay; Cells; Childhood; Clinical; Clinical Data; Code; Communities; Custom; Cytometry; Data; Data Analyses; Data Coordinating Center; Data Set; Dengue Virus; Development; Disease; Ensure; Human; Immune; Immunology; Infection; Laboratories; Measures; Methods; Mycobacterium tuberculosis; Process; Recording of previous events; Running; System; Testing; Translating; Vaccination; Validation; Work; cell type; clinical research site; data standards; data submission; data warehouse; experience; improved; interoperability; method development; molecular marker; population based; repository; single cell sequencing; success; working group

Our group has developed a set of data standards over the years to capture different aspects of immune profiling studies that enable the description of, for example, the immune exposure being studied (e.g. type and course of infection or vaccination) or the molecular markers measured in a cytometry assay and how they relate detected cells to specific cell types. These standards were primarily developed for the Human Immunology Project Consortium (HIPC), and were tailored to be interoperable with the ImmPort submission system, in which they have been adopted and are now used for all data submissions into ImmPort. For HIPC, these standards have enabled cross-center data analysis projects and method development. As part of this work, automated validation routines have been created that test ImmPort data submissions for their adherence to these data standards, which has enabled us to identify and correct issues in data submissions..

多年来，我们的团队开发了一套数据标准，以捕捉免疫系统的不同方面