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Large Scale T Cell Epitope Discovery: Global identification of epitopes derived from Zika (ZIKV) and Chikungunya (CHIKV) viruses following natural infection and vaccination

Large Scale T Cell Epitope Discovery: Global identification of epitopes derived from Zika (ZIKV) and Chikungunya (CHIKV) viruses following natural infection and vaccination
大规模 T 细胞表位发现：在自然感染和疫苗接种后对寨卡病毒 (ZIKV) 和基孔肯雅病毒 (CHIKV) 衍生的表位进行全面鉴定
批准号：
10020640
负责人：
Alessandro Sette
金额：
$88.83万
依托单位：
LA JOLLA INSTITUTE FOR IMMUNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-09-30 至 2020-09-29
来源：
https://reporter.nih.gov/project-details/10020640
关键词：
AddressAffectAntigensArbovirusesAreaBindingBiological AssayCD8B1 geneChikungunya virusCommunitiesComputer softwareDataDatabasesDevelopmentDiagnosticEpitopesExposure toFeverGeneral PopulationHealthHumanImmuneImmunodominant EpitopesIn VitroIndividualInfectionLaboratoriesMediatingPathogenesisResearchResourcesRoleSupport ContractsT-LymphocyteT-Lymphocyte EpitopesTestingVaccinationVaccinesValidationVirusWorkZika Viruschikungunyaimmunogenicitymultidisciplinarytoolvalidation studies

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中文摘要
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英文摘要
This contract supports highly interactive, multi-disciplinary teams, whose research efforts are focused on large-scale discovery of T cell immune epitopes, validation of these epitopes, and defining their role in immune protection or immune-mediated pathogenesis in humans. Milestones include: 1) epitope identification; 2) in vitro epitope validation studies with primary human T cells to demonstrate the immunogenicity/antigenicity or diagnostic potential of all newly defined T cell epitopes shown to bind to classical or non-classical MHC molecules; and 3) submission of all epitope information and computer software to the Immune Epitope Database and Analysis Resource to facilitate access and use of the data and tools by the broader research community.
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  • 依托单位：
    LA JOLLA INSTITUTE FOR IMMUNOLOGY
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  • 项目类别：
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