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Clinical Studies and LN FNA Core

临床研究和 LN FNA 核心

基本信息

批准号：
10580754
负责人：
Alessandro Sette
金额：
$ 16.38万
依托单位：
LA JOLLA INSTITUTE FOR IMMUNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-11 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10580754
关键词：
Adherence Adult Antigens Axilla B-Lymphocytes Bacteria Biopsy Blood Blood donor Blood specimen CD4 Positive T Lymphocytes Cells Child Clinical Clinical Research Code Collaborations Dengue Virus Diagnosis Ensure Epigenetic Process Fine needle aspiration biopsy Foundations Goals Human Human Herpesvirus 4 Immunization Immunize Individual Institutional Review Boards Lung Lymph Node Tissue Maintenance Malignant neoplasm of lung Mediastinal lymph node group Operative Surgical Procedures Pathologic Patients Pattern Pediatric Hospitals Peripheral Blood Mononuclear Cell Pertussis Pertussis Vaccine Plasma Preparation Procedures Protocols documentation Quality Control Recurrence Research Institute Resected Resources Role Sampling Sampling Studies Secondary to Site Source Streptococcus pyogenes Structure of parenchyma of lung T cell response Tissue Sample Tissues Tonsil Tonsillectomy Tonsillitis Translational Research Vaccinated Vaccinee Vaccines Virus Virus Diseases Work Yellow Fever Vaccine Yellow fever virus cohort cytotoxic design draining lymph node expectation infancy lymph node biopsy lymph nodes minimally invasive programs recruit research study response retention rate success tumor ultrasound

项目摘要

CLINICAL STUDIES AND LN FNA CORE (CORE B) CORE SUMMARY The success of the entire program is contingent upon successful accrual of human samples. We are confident in our ability to amass the necessary samples that will enable the most robust and compelling studies. The Clinical Studies and LN FNA Core will provide a centralized resource for accrual of human lymph node (LN), lung, peripheral blood mononuclear cells (PBMC) and plasma samples, and ensure the quality and uniformity of handling of the samples received. These functions are crucial to provide a strong foundation for the studies described in the three proposed projects. The Clinical Studies and LN FNA Core will work closely with the individual Projects, the Administrative Core, the Sequencing and Epigenetics Core, and the clinical subcontractors to enable success of all objectives in this program proposal. This Core will be responsible for the preparation and maintenance of IRB protocols, oversight of subject recruitment, quality control of coded clinical information and donor samples. The cohorts to be used for this program include samples from well- regarded and successful collaborators and clinicians. We will work closely with Drs. F. Hasteh (UCSD) and S. Yekezare (UCSD) and the Altman Clinical and Translational Research Institute (ACTRI) at UCSD to enable acquisition of lymph node fine needle aspirate (LN FNA) samples for Projects 1, 2 and 3. We have a long- standing collaboration with Dr. M.T. Brigger (Rady Children's, UCSD) to obtain tonsil samples to be used for Projects 1 and 3. We also will collaborate with Dr. Ottensmeier (Southampton, UK) to obtain lung and lung- draining lymph node tissue samples for Projects 1 and 3. LJI's in-house Clinical Core will manage the banked samples from vaccinated individuals for Project 2 and will provide all new samples from pertussis- and yellow fever virus-vaccinated donors needed for Projects 1, 2 and 3.

临床研究和LN FNA核心(核心B) 核心摘要整个项目的成功取决于人体样本的成功采集。我们有信心我们收集必要样本的能力将使最有力和最令人信服的研究成为可能。这个临床研究和LN FNA核心将为人类淋巴结(LN)的积累提供集中资源，肺、外周血单核细胞(PBMC)和血浆样本，并确保质量和一致性对收到的样品的处理。这些功能对于为研究提供坚实的基础至关重要三个拟议项目中所描述的。临床研究和LN FNA核心将与个人项目、管理核心、测序和表观遗传学核心以及临床分包商确保本计划建议书中所有目标的成功。这一核心将负责编制和维护IRB方案，监督受试者招募，编码的质量控制临床信息和捐献者样本。用于这项计划的队列包括来自油井的样本- 受人尊敬和成功的合作者和临床医生。我们将与加州大学圣迭戈分校的F.Hasteh博士和S. 加州大学洛杉矶分校的Yekezare(UCSD)和Altman临床与翻译研究所(ACTRI) 获取项目1、2和3的淋巴结细针抽吸物(LN FNA)样本。我们有一个长期的- 与M.T.Brigger博士(加州大学拉迪儿童分校)长期合作，获取扁桃体样本用于项目1和项目3。我们还将与英国南安普敦的Ottensmeier博士合作，获取肺和肺- 为项目1和项目3抽干淋巴组织样本。LJI的内部临床核心将管理银行来自项目2接种疫苗的个人的样本，并将提供所有新的百日咳和黄色样本项目1、2和3需要接种发热病毒疫苗的捐赠者。