Clinical Studies and LN FNA Core
临床研究和 LN FNA 核心
基本信息
- 批准号:10580754
- 负责人:
- 金额:$ 16.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-03-11 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:AdherenceAdultAntigensAxillaB-LymphocytesBacteriaBiopsyBloodBlood donorBlood specimenCD4 Positive T LymphocytesCellsChildClinicalClinical ResearchCodeCollaborationsDengue VirusDiagnosisEnsureEpigenetic ProcessFine needle aspiration biopsyFoundationsGoalsHumanHuman Herpesvirus 4ImmunizationImmunizeIndividualInstitutional Review BoardsLungLymph Node TissueMaintenanceMalignant neoplasm of lungMediastinal lymph node groupOperative Surgical ProceduresPathologicPatientsPatternPediatric HospitalsPeripheral Blood Mononuclear CellPertussisPertussis VaccinePlasmaPreparationProceduresProtocols documentationQuality ControlRecurrenceResearch InstituteResectedResourcesRoleSamplingSampling StudiesSecondary toSiteSourceStreptococcus pyogenesStructure of parenchyma of lungT cell responseTissue SampleTissuesTonsilTonsillectomyTonsillitisTranslational ResearchVaccinatedVaccineeVaccinesVirusVirus DiseasesWorkYellow Fever VaccineYellow fever viruscohortcytotoxicdesigndraining lymph nodeexpectationinfancylymph node biopsylymph nodesminimally invasiveprogramsrecruitresearch studyresponseretention ratesuccesstumorultrasound
项目摘要
CLINICAL STUDIES AND LN FNA CORE (CORE B)
CORE SUMMARY
The success of the entire program is contingent upon successful accrual of human samples. We are confident
in our ability to amass the necessary samples that will enable the most robust and compelling studies. The
Clinical Studies and LN FNA Core will provide a centralized resource for accrual of human lymph node (LN),
lung, peripheral blood mononuclear cells (PBMC) and plasma samples, and ensure the quality and uniformity
of handling of the samples received. These functions are crucial to provide a strong foundation for the studies
described in the three proposed projects. The Clinical Studies and LN FNA Core will work closely with the
individual Projects, the Administrative Core, the Sequencing and Epigenetics Core, and the clinical
subcontractors to enable success of all objectives in this program proposal. This Core will be responsible for
the preparation and maintenance of IRB protocols, oversight of subject recruitment, quality control of coded
clinical information and donor samples. The cohorts to be used for this program include samples from well-
regarded and successful collaborators and clinicians. We will work closely with Drs. F. Hasteh (UCSD) and S.
Yekezare (UCSD) and the Altman Clinical and Translational Research Institute (ACTRI) at UCSD to enable
acquisition of lymph node fine needle aspirate (LN FNA) samples for Projects 1, 2 and 3. We have a long-
standing collaboration with Dr. M.T. Brigger (Rady Children's, UCSD) to obtain tonsil samples to be used for
Projects 1 and 3. We also will collaborate with Dr. Ottensmeier (Southampton, UK) to obtain lung and lung-
draining lymph node tissue samples for Projects 1 and 3. LJI's in-house Clinical Core will manage the banked
samples from vaccinated individuals for Project 2 and will provide all new samples from pertussis- and yellow
fever virus-vaccinated donors needed for Projects 1, 2 and 3.
临床研究和LN FNA核心(核心B)
核心摘要
整个计划的成功取决于人类样本的成功采集。我们相信
我们有能力收集必要的样本,以便进行最有力和最引人注目的研究。的
临床研究和LN FNA核心将为人类淋巴结(LN)的累积提供集中资源,
肺、外周血单个核细胞(PBMC)和血浆样本,并保证质量和均匀性
处理收到的样品。这些功能对于为研究提供坚实的基础至关重要
在三个项目中,临床研究和LN FNA核心将与
个别项目,行政核心,测序和表观遗传学核心,以及临床
分包商,以使本计划提案中的所有目标的成功。该核心将负责
IRB方案的准备和维护,受试者招募的监督,编码的质量控制
临床信息和供体样本。用于该计划的队列包括来自井的样本-
受人尊敬和成功的合作者和临床医生。我们将与F博士密切合作。Hasteh(UCSD)和S.
Yekezare(UCSD)和UCSD的Altman临床和转化研究所(ACTRI),
采集项目1、2和3的淋巴结细针穿刺(LN FNA)样本。我们有很长的-
与M.T.博士长期合作Brigger(Rady Children's,UCSD)获得扁桃体样本,用于
项目1和3。我们还将与Ottensmeier博士(南安普顿,英国)合作,获得肺和肺-
项目1和3的引流淋巴结组织样本。LJI的内部临床核心将管理
从项目2接种疫苗的个体中采集样本,并将提供百日咳和黄热病的所有新样本
项目1、2和3所需的发热病毒接种捐助者。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alessandro Sette其他文献
Alessandro Sette的其他文献
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{{ truncateString('Alessandro Sette', 18)}}的其他基金
Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination
感染、疾病和疫苗接种中登革热病毒和结核分枝杆菌暴露的人体免疫特征
- 批准号:
10265651 - 财政年份:2020
- 资助金额:
$ 16.38万 - 项目类别:
Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination
感染、疾病和疫苗接种中登革热病毒和结核分枝杆菌暴露的人体免疫特征
- 批准号:
10228367 - 财政年份:2020
- 资助金额:
$ 16.38万 - 项目类别:
Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination
感染、疾病和疫苗接种中登革热病毒和结核分枝杆菌暴露的人体免疫特征
- 批准号:
10056696 - 财政年份:2020
- 资助金额:
$ 16.38万 - 项目类别:
Large Scale T Cell Epitope Discovery: Global identification of epitopes derived from Zika (ZIKV) and Chikungunya (CHIKV) viruses following natural infection and vaccination
大规模 T 细胞表位发现:在自然感染和疫苗接种后对寨卡病毒 (ZIKV) 和基孔肯雅病毒 (CHIKV) 衍生的表位进行全面鉴定
- 批准号:
10020640 - 财政年份:2019
- 资助金额:
$ 16.38万 - 项目类别:
Large Scale T Cell Epitope Discovery: Genome-wide characterization of T cell epitopes from Bordetella pertussis in vaccination and natural infection
大规模 T 细胞表位发现:疫苗接种和自然感染中百日咳博德特氏菌 T 细胞表位的全基因组特征
- 批准号:
10616655 - 财政年份:2019
- 资助金额:
$ 16.38万 - 项目类别:
Large Scale T Cell Epitope Discovery: Genome-wide characterization of T cell epitopes from Bordetella pertussis in vaccination and natural infection
大规模 T 细胞表位发现:疫苗接种和自然感染中百日咳博德特氏菌 T 细胞表位的全基因组特征
- 批准号:
10439413 - 财政年份:2019
- 资助金额:
$ 16.38万 - 项目类别:
Mechanisms of differential responses to whole cell and acellular pertussis vaccination
全细胞和无细胞百日咳疫苗接种的差异反应机制
- 批准号:
10580758 - 财政年份:2019
- 资助金额:
$ 16.38万 - 项目类别:
Mechanisms of differential responses to whole cell and acellular pertussis vaccination
全细胞和无细胞百日咳疫苗接种的差异反应机制
- 批准号:
10366648 - 财政年份:2019
- 资助金额:
$ 16.38万 - 项目类别:
Mechanisms of differential responses to whole cell and acellular pertussis vaccination
全细胞和无细胞百日咳疫苗接种的差异反应机制
- 批准号:
10585309 - 财政年份:2019
- 资助金额:
$ 16.38万 - 项目类别:
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