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Clinical Studies and LN FNA Core

临床研究和 LN FNA 核心

基本信息

批准号：
10580754
负责人：
Alessandro Sette
金额：
$ 16.38万
依托单位：
LA JOLLA INSTITUTE FOR IMMUNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-11 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10580754
关键词：
Adherence Adult Antigens Axilla B-Lymphocytes Bacteria Biopsy Blood Blood donor Blood specimen CD4 Positive T Lymphocytes Cells Child Clinical Clinical Research Code Collaborations Dengue Virus Diagnosis Ensure Epigenetic Process Fine needle aspiration biopsy Foundations Goals Human Human Herpesvirus 4 Immunization Immunize Individual Institutional Review Boards Lung Lymph Node Tissue Maintenance Malignant neoplasm of lung Mediastinal lymph node group Operative Surgical Procedures Pathologic Patients Pattern Pediatric Hospitals Peripheral Blood Mononuclear Cell Pertussis Pertussis Vaccine Plasma Preparation Procedures Protocols documentation Quality Control Recurrence Research Institute Resected Resources Role Sampling Sampling Studies Secondary to Site Source Streptococcus pyogenes Structure of parenchyma of lung T cell response Tissue Sample Tissues Tonsil Tonsillectomy Tonsillitis Translational Research Vaccinated Vaccinee Vaccines Virus Virus Diseases Work Yellow Fever Vaccine Yellow fever virus cohort cytotoxic design draining lymph node expectation infancy lymph node biopsy lymph nodes minimally invasive programs recruit research study response retention rate success tumor ultrasound

项目摘要

CLINICAL STUDIES AND LN FNA CORE (CORE B) CORE SUMMARY The success of the entire program is contingent upon successful accrual of human samples. We are confident in our ability to amass the necessary samples that will enable the most robust and compelling studies. The Clinical Studies and LN FNA Core will provide a centralized resource for accrual of human lymph node (LN), lung, peripheral blood mononuclear cells (PBMC) and plasma samples, and ensure the quality and uniformity of handling of the samples received. These functions are crucial to provide a strong foundation for the studies described in the three proposed projects. The Clinical Studies and LN FNA Core will work closely with the individual Projects, the Administrative Core, the Sequencing and Epigenetics Core, and the clinical subcontractors to enable success of all objectives in this program proposal. This Core will be responsible for the preparation and maintenance of IRB protocols, oversight of subject recruitment, quality control of coded clinical information and donor samples. The cohorts to be used for this program include samples from well- regarded and successful collaborators and clinicians. We will work closely with Drs. F. Hasteh (UCSD) and S. Yekezare (UCSD) and the Altman Clinical and Translational Research Institute (ACTRI) at UCSD to enable acquisition of lymph node fine needle aspirate (LN FNA) samples for Projects 1, 2 and 3. We have a long- standing collaboration with Dr. M.T. Brigger (Rady Children's, UCSD) to obtain tonsil samples to be used for Projects 1 and 3. We also will collaborate with Dr. Ottensmeier (Southampton, UK) to obtain lung and lung- draining lymph node tissue samples for Projects 1 and 3. LJI's in-house Clinical Core will manage the banked samples from vaccinated individuals for Project 2 and will provide all new samples from pertussis- and yellow fever virus-vaccinated donors needed for Projects 1, 2 and 3.

临床研究和LN FNA核心（核心B）核心摘要整个计划的成功取决于人类样本的成功采集。我们相信我们有能力收集必要的样本，以便进行最有力和最引人注目的研究。的临床研究和LN FNA核心将为人类淋巴结（LN）的累积提供集中资源，肺、外周血单个核细胞（PBMC）和血浆样本，并保证质量和均匀性处理收到的样品。这些功能对于为研究提供坚实的基础至关重要在三个项目中，临床研究和LN FNA核心将与个别项目，行政核心，测序和表观遗传学核心，以及临床分包商，以使本计划提案中的所有目标的成功。该核心将负责 IRB方案的准备和维护，受试者招募的监督，编码的质量控制临床信息和供体样本。用于该计划的队列包括来自井的样本- 受人尊敬和成功的合作者和临床医生。我们将与F博士密切合作。Hasteh（UCSD）和S. Yekezare（UCSD）和UCSD的Altman临床和转化研究所（ACTRI），采集项目1、2和3的淋巴结细针穿刺（LN FNA）样本。我们有很长的- 与M.T.博士长期合作Brigger（Rady Children's，UCSD）获得扁桃体样本，用于项目1和3。我们还将与Ottensmeier博士（南安普顿，英国）合作，获得肺和肺- 项目1和3的引流淋巴结组织样本。LJI的内部临床核心将管理从项目2接种疫苗的个体中采集样本，并将提供百日咳和黄热病的所有新样本项目1、2和3所需的发热病毒接种捐助者。