University of Michigan O'Brien Kidney Translational Core Center

摘要-中心概述 为了迅速开发有效的治疗方法来预防或逆转慢性肾脏疾病的进展 密歇根大学奥布莱恩肾脏翻译核心中心(CKD)将支持全频谱 为我们的机构和临床研究人员提供资源的翻译管道 国际研究基地采用三管齐下的方法： 我们独特的慢性肾脏病队列结合其纵向组织、尿液和血清的扩展 生物库使我们的研究基地的研究人员能够调查分子原因和 慢性肾脏疾病的终点； 传播和支持最现代和最强大的系统生物学方法 研究基地调查人员帮助他们有效地识别新的和强大的生物标记物， 慢性肾脏病诊断和治疗的终点和靶点； 为我们的研究基地调查人员提供队列和系统数据的专家分析和集成 通过使用先进的生物信息学和数据库集成来促进 确定个人或受试者群体治疗的具体途径和目标 与CKD合作。 该中心的目标是： 1)通过以下方式扩大肾脏疾病研究的翻译和系统生物学方法 通过临床中心扩大CKD深层临床表型和生物库的努力 表型鉴定与资源库核心(C-Probe) 2)引进、刺激和应用最先进的系统生物学方法来治疗肾脏疾病 我们的机构研究核心研究员通过使用高级研究工具进行的研究 但用户友好的遗传、转录组、蛋白质组、代谢组和脂肪组学方法 通过应用系统生物学核心； 3)加强对复杂肾脏疾病和多标量数据集的了解 伴随系统对肾脏功能影响的生物学研究 通过数据分析了解疾病的发展、诊断、进展和治疗潜力 服务核心(DASC)； 4)通过Nephroseq和TRANSMART扩大全球范围的推广工作； 5)使用肾脏教育充实计划和试点和可行性计划来吸引 受训人员和教职员工致力于肾脏研究，并支持我们的肾脏研究基地 研究。

ABSTRACT – CENTER OVERVIEW In order to rapidly develop effective therapies to prevent or reverse progression of chronic kidney disease (CKD), the University of Michigan O'Brien Kidney Translational Core Center will support the full spectrum of a translational pipeline providing resources to basic and clinical investigators in our Institutional and International Research Bases using a 3-pronged approach:  Expansion of our unique CKD cohort combined with its longitudinal tissue, urine and serum biobanks to allow our research base investigators to investigate the molecular causes and endpoints of chronic kidney diseases;  Dissemination and support of the most modern and powerful systems biological approaches for research base investigators to help them effectively identify novel and robust biomarkers, endpoints and targets for diagnosis and treatment of CKD;  Expert analysis and integration of cohort and systems data for our research base investigators through the use of sophisticated bioinformatics and database integration that promote identification of specific pathways and targets for treatments for individuals or groups of subjects with CKD. The Center's aims are to: 1) Expand translational and systems biological approaches to kidney disease research by expanding the Center's CKD deep clinical phenotyping and biobanking efforts through the Clinical Phenotyping and Resource Biobank Core (C-PROBE); 2) Introduce, stimulate and apply state-of-the-art systems biological approaches to kidney disease research studies by our Institutional Research Core investigators through the use of sophisticated but user-friendly genetic, transcriptomic, proteomic, metabolomic and lipidomic approaches through the Applied Systems Biology Core; 3) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that accompany systems biological approaches to their functional implications regarding kidney disease development, diagnosis, progression and therapeutic potential through the Data Analytic Services Core (DASC); 4) Expand worldwide outreach efforts via Nephroseq and tranSMART; 5) Use the Kidney Educational Enrichment Programs and the Pilot and Feasibility Program to entice trainees and faculty into kidney research and support our research bases in their ongoing kidney research.