Developmental Core

发展核心

• 批准号: 9062027
• 负责人: Subramaniam Pennathur
• 金额: $ 89.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9062027
• 关键词: Acute; Bioinformatics; Biological; Biological Markers; Birth; Characteristics; Chemicals; Child health care; Chronic; Clinical Research; Communities; Data; Databases; Detection; Development; Diet; Dietary Practices; Dietary intake; Disease; Electrons; Electrospray Ionization; Environment; Environmental Health; Exposure to; Funding; Gas Chromatography; Goals; High Pressure Liquid Chromatography; Inflammation; Informatics; Injury; Knowledge; Laboratories; Link; Measurement; Measures; Methodology; Methods; Michigan; National Institute of Environmental Health Sciences; Nuclear Magnetic Resonance; Oxidants; Oxidative Stress; Phase; Plasma; Pregnancy; Process; Program Research Project Grants; Protocols documentation; Provider; Puerto Rico; Research; Research Personnel; Resources; Sampling; Science; Services; Superfund; Technology; Testing; Time; Tissues; Urine; Work; analytical tool; cohort; computerized data processing; data integration; epidemiology study; improved; interest; ionization; metabolomics; new technology; novel; novel marker; response; tool

ABSTRACT (Development Core) The primary objective of the Michigan Children’s Health Exposure Analysis Resource (M-CHEAR) Laboratory Hub is to contribute to large-scale national efforts to advance our knowledge of the impact of the environment on children’s health by offering high-quality, advanced laboratory support for a wide assortment of targeted and untargeted analyses in biological samples from external researchers conducting epidemiology and clinical studies of children’s health. The Aims of the Developmental Core (DC) are to provide M-CHEAR investigators with novel analytical tools relevant to exposure assessment. These include developing novel technology platforms for comprehensive metabolomic analysis, identifying unknown metabolites, developing new methods for targeted metabolomics in a range of biological matrices, validating new biological response indicators and providing biological context to diverse metabolomic measurements through bioinformatics analysis and developing new bioinformatics tools. To this end, the DC will work closely with the Targeted Analysis (TAR), the Untargeted Analysis (UAR) and the Biological Response Resources (BRIR) and with M-CHEAR investigators to develop and implement new technologies to aid investigators in testing their research questions. Finally, utilizing a demonstration study, DC will be able to reach its goal of developing and optimizing new methods for exposure assessment in biological samples that would be of broad interest to the environmental and children’s health research community. To achieve these goals the DC will:. To achieve these goals the DC will: • Develop new protocols for measurement of analytes for which there are no existing methods, analysis of new biological matrices and expand capabilities of the current platforms. • Provide biological context to numerous and diverse biomarker measurements by data integration through cutting edge bioinformatics tools. • Identification of unknown compounds discovered by the Untargeted Analysis Resource. • Development of novel signatures of oxidative stress, dietary patterns and functional measures of biological response. • Conduct a demonstration study as proof-of-principle to generate data from M-CHEAR Cores and utilize DC to develop novel analytical tools. • Coordinate with other CHEAR Hubs, Steering Committee, Coordinating Center and the Data Repository, Analysis and Science Center to develop methods of high priority to CHEAR.

摘要（开发核心） 密歇根儿童健康暴露分析资源实验室（Michigan Children's Health Exposure Analysis Resource Laboratory，M-CHEARS） 该中心旨在为大规模的国家努力做出贡献，以提高我们对环境影响的认识 通过提供高质量，先进的实验室支持， 对来自进行流行病学和临床研究的外部研究人员的生物样本进行非靶向分析 儿童健康的研究。发展核心（DC）的目的是为M-CHESTIC研究人员提供 与接触评估相关的新分析工具。其中包括开发新技术 综合代谢组学分析平台，识别未知代谢物，开发新方法 用于一系列生物基质中的靶向代谢组学，验证新的生物反应指标， 通过生物信息学分析为不同的代谢组学测量提供生物学背景， 开发新的生物信息学工具。为此，发展委员会将与目标分析小组密切合作， 非靶向分析（UAR）和生物反应资源（BRIR），以及M-CHEMICAL 研究人员开发和实施新技术，以帮助研究人员测试他们的研究 问题.最后，利用示范研究，DC将能够实现其发展和 优化生物样品中暴露评估的新方法， 环境和儿童健康研究社区。为了实现这些目标，DC将： 为实现这些目标，DC将： ·开发新的协议，用于测量现有方法无法测量的分析物， 新的生物基质和扩大现有平台的能力。 ·通过数据整合为众多不同的生物标志物测量提供生物背景 通过尖端的生物信息学工具。 ·识别由非目标分析资源发现的未知化合物。 ·开发氧化应激的新特征，饮食模式和功能措施， 生物反应。 ·进行示范研究作为原理证明，以从M-CHEMICAL核心生成数据并利用 DC开发新的分析工具。 ·与其他CHEMICAL中心、指导委员会、协调中心和数据中心协调 知识库、分析和科学中心，以开发对CHEMICAL高度优先的方法。