Developmental Core
发展核心
基本信息
- 批准号:9062027
- 负责人:
- 金额:$ 89.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-30 至 2021-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteBioinformaticsBiologicalBiological MarkersBirthCharacteristicsChemicalsChild health careChronicClinical ResearchCommunitiesDataDatabasesDetectionDevelopmentDietDietary PracticesDietary intakeDiseaseElectronsElectrospray IonizationEnvironmentEnvironmental HealthExposure toFundingGas ChromatographyGoalsHigh Pressure Liquid ChromatographyInflammationInformaticsInjuryKnowledgeLaboratoriesLinkMeasurementMeasuresMethodologyMethodsMichiganNational Institute of Environmental Health SciencesNuclear Magnetic ResonanceOxidantsOxidative StressPhasePlasmaPregnancyProcessProgram Research Project GrantsProtocols documentationProviderPuerto RicoResearchResearch PersonnelResourcesSamplingScienceServicesSuperfundTechnologyTestingTimeTissuesUrineWorkanalytical toolcohortcomputerized data processingdata integrationepidemiology studyimprovedinterestionizationmetabolomicsnew technologynovelnovel markerresponsetool
项目摘要
ABSTRACT (Development Core)
The primary objective of the Michigan Children’s Health Exposure Analysis Resource (M-CHEAR) Laboratory
Hub is to contribute to large-scale national efforts to advance our knowledge of the impact of the environment
on children’s health by offering high-quality, advanced laboratory support for a wide assortment of targeted and
untargeted analyses in biological samples from external researchers conducting epidemiology and clinical
studies of children’s health. The Aims of the Developmental Core (DC) are to provide M-CHEAR investigators
with novel analytical tools relevant to exposure assessment. These include developing novel technology
platforms for comprehensive metabolomic analysis, identifying unknown metabolites, developing new methods
for targeted metabolomics in a range of biological matrices, validating new biological response indicators and
providing biological context to diverse metabolomic measurements through bioinformatics analysis and
developing new bioinformatics tools. To this end, the DC will work closely with the Targeted Analysis (TAR),
the Untargeted Analysis (UAR) and the Biological Response Resources (BRIR) and with M-CHEAR
investigators to develop and implement new technologies to aid investigators in testing their research
questions. Finally, utilizing a demonstration study, DC will be able to reach its goal of developing and
optimizing new methods for exposure assessment in biological samples that would be of broad interest to the
environmental and children’s health research community. To achieve these goals the DC will:.
To achieve these goals the DC will:
• Develop new protocols for measurement of analytes for which there are no existing methods, analysis
of new biological matrices and expand capabilities of the current platforms.
• Provide biological context to numerous and diverse biomarker measurements by data integration
through cutting edge bioinformatics tools.
• Identification of unknown compounds discovered by the Untargeted Analysis Resource.
• Development of novel signatures of oxidative stress, dietary patterns and functional measures of
biological response.
• Conduct a demonstration study as proof-of-principle to generate data from M-CHEAR Cores and utilize
DC to develop novel analytical tools.
• Coordinate with other CHEAR Hubs, Steering Committee, Coordinating Center and the Data
Repository, Analysis and Science Center to develop methods of high priority to CHEAR.
摘要(发展核心)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Subramaniam Pennathur其他文献
Subramaniam Pennathur的其他文献
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{{ truncateString('Subramaniam Pennathur', 18)}}的其他基金
University of Michigan O'Brien Kidney Translational Resource Center (MKTC)
密歇根大学奥布莱恩肾脏转化资源中心 (MKTC)
- 批准号:
10746899 - 财政年份:2023
- 资助金额:
$ 89.9万 - 项目类别:
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