Hyperpolarized 13C Probes for Imaging Warburg Metabolism in Cancer

项目概要/摘要。 虽然医学成像已经成为癌症诊断的重要组成部分，但许多 传统技术在疾病发病的早期阶段仍然不足， 肿瘤的本工作的目的是开发超极化13 C显像剂， 有效地提供了对肿瘤代谢谱的了解，从而提供了一种新的 用于识别恶性组织的临床工具。这些化学探针将针对癌症的一个标志 这种代谢被称为瓦尔堡效应，其中糖酵解活性的增加和 观察到通过三羧酸循环的氧化磷酸化减少。小说 将制备13 C标记的分子探针文库，以优化它们的物理和 临床研究的化学性质。这些药物将用于超极化 使用体外和体内癌症模型的13 C磁共振光谱研究， 确定癌症成像的理想候选人。因此，这些超极化13 C探针将 为癌症诊断提供新的方法，并为监测提供新的机会 肿瘤代谢的独特方面，这对一系列科学研究具有广泛的重要性。 和生物医学社区。

Project Summary/Abstract. Although medical imaging has become an essential component in cancer diagnosis, many traditional technologies remain inadequate at early stages of disease onset or with localized tumors. The objective of this work is the development of hyperpolarized 13C imaging agents that effectively provide insight into the metabolic profile of tumors and thereby provide a novel clinical tool to identify malignant tissues. These chemical probes will target a hallmark of cancer metabolism known as the Warburg effect, where an increase in glycolytic activity and a decrease in oxidative phosphorylation via the tricarboxylic acid cycle are observed. Novel libraries of 13C-labeled molecular probes will be prepared in order to optimize their physical and chemical properties for clinical investigations. These agents will be employed in hyperpolarized 13C magnetic resonance spectroscopic studies using both in vitro and in vivo cancer models to identify ideal candidates for cancer imaging. These hyperpolarized 13C probes will therefore provide novel methods for cancer diagnosis and offer new opportunities for monitoring distinctive aspects of tumor metabolism, which is of broad importance to a range of scientific and biomedical communities.